A5013587097- Natural product bioactivities and synthesis
- Aldose Reductase and Taurine
- Pharmacological Effects of Natural Compounds
- Phytochemicals and Antioxidant Activities
- Natural Antidiabetic Agents Studies
- Chromatography in Natural Products
- Phytochemistry and Biological Activities
- Plant Toxicity and Pharmacological Properties
- Advanced Glycation End Products research
- Neuroinflammation and Neurodegeneration Mechanisms
- Fungal Biology and Applications
- Medicinal Plant Extracts Effects
- Medicinal Plants and Neuroprotection
- Medicinal plant effects and applications
- Inflammatory mediators and NSAID effects
- Phytoestrogen effects and research
- Biochemical effects in animals
- RNA Interference and Gene Delivery
- Natural Products and Biological Research
- Genomics, phytochemicals, and oxidative stress
- NF-κB Signaling Pathways
- Antioxidant Activity and Oxidative Stress
- Biochemical and biochemical processes
- Bioactive Compounds and Antitumor Agents
- Pain Mechanisms and Treatments
Hallym University
2016-2025
Hallym Polytechnic University
2013-2024
CTCBio (South Korea)
2023
Government of the Republic of Korea
2018
Institute of Natural Science
2018
Hallym University Medical Center
2008-2015
Kangwon National University
2011
Pukyong National University
2007
Biotechnology Research Center
2004-2006
Chosun University
2005
Fruits of bog blueberry (Vaccinium uliginosum L.) are rich in anthocyanins that contribute pigmentation. Anthocyanins have received much attention as agents with potentials preventing chronic diseases. This study investigated the capacity anthocyanin-rich extract from (ATH-BBe) to inhibit photoaging UV-B-irradiated human dermal fibroblasts. BBe were detected cyanidin-3-glucoside, petunidin-3-glucoside, malvidin-3-glucoside, and delphinidin3-glucoside. ATH-BBe attenuated UV-B-induced toxicity...
Glandular trichomes are the phytochemical factories of plants, and they secrete a wide range commercially important natural products such as lipids, terpenes flavonoids. Herein, we report that Nicotiana tabacum LTP1 (NtLTP1) gene, which is specifically expressed in long glandular trichomes, plays role lipid secretion from trichome heads. NtLTP1 mRNA abundantly transcribed but NtLTP3, NtLTP4 NtLTP5 not. In situ hybridization revealed mRNAs accumulate not short or epidermal cells. X-gluc...
Macrophage polarization has been implicated in the pathogenesis of obesity and type 2 diabetes, which are recognized as chronic proinflammatory diseases. This study investigated that high level glucose, similar to lipopolysaccharide (LPS), activated macrophages toward M1 phenotypes 1–20 μM asaronic acid (AA) counteracted diabetic macrophage activation. AA reduced LPS-promoted secretion interleukin (IL)-6 monocyte chemoattractant protein-1. The LPS markedly elevated induction markers...
Aldose reductase, the key enzyme of polyol pathway, and oxidative stress are known to play important roles in complications diabetes. A drug with potent inhibition aldose reductase stress, therefore, would be a most promising for prevention diabetic complications. The purpose this study was develop new compounds these dual-effects through synthesis chalcone derivatives by examining structure-activity relationships on rat lens as well antioxidant effects. series 35 flavonoid were synthesized...
Abstract Aldose reductase, the principal enzyme of polyol pathway, has been shown to play an important role in complications associated with diabetes. A methanol extract stamens Nelumbo nucifera Gaertn. was exert inhibitory effect on rat lens aldose reductase (RLAR), and thus fractionated using several organic solvents, including dichloromethane, ethyl acetate n ‐butanol. The acetate‐soluble fraction, which manifested potent RLAR‐inhibitory properties, then purified further via repeated...
In the present study, we evaluated in vitro and vivo anti-angiogenic anti-tumor activities of 2′-hydroxy-4′-methoxychalcone (HMC). HMC decreased angiogenesis both chick embryos chorioallantoic membrane assay basic fibroblast growth factor (bFGF)-induced vessel formation mouse Matrigel plug assay. This compound also reduced proliferation calf pulmonary arterial endothelial cells was found to possess relatively weak gelatinase/collagenase inhibitory activity vitro. HMC, when administered...
Abstract The extract of the root Acanthopanax chiisanensis Nakai is used for treatment inflammation. To analyse action mechanism this extract, effect hyperin (quercetin‐3‐ O ‐ β d ‐galactose) isolated from ethyl acetate fraction A. on nitrite production and induction inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS, 1 µg/mL)‐stimulated rat peritoneal macrophages were examined. structurally related compounds, isoquercitrin ‐glucose) quercetin (an aglycone two compounds)...
Diabetic nephropathy (DN) is one of the major diabetic complications and leading cause end-stage renal disease. Abnormal angiogenesis results in new vessels that are often immature play a pathological role DN, contributing to fibrosis disrupting glomerular failure. Purple corn has been utilized as daily food exerts disease-preventive activities. This study was designed investigate whether anthocyanin-rich purple extract (PCE) prevented under hyperglycemic conditions. Human endothelial cells...
The goal of this study was to determine the rat lens aldose reductase-inhibitory effects 95% ethanol extracts from leaves C. esculenta and, its organic solvent soluble fractions, including dichloromethane (CH2Cl2), ethyl acetate (EtOAc), n-butanol (BuOH) and water (H2O) layers, using dl-glyceraldehyde as a substrate. Ten compounds, namely tryptophan (1), orientin (2), isoorientin (3), vitexin (4), isovitexin (5), luteolin-7-O-glucoside (6), luteolin-7-O-rutinoside (7), rosmarinic acid (8),...
Context:Citrus unshiu Markovich (Rutaceae) peel is known to contain high concentrations of flavonoids and exerts pharmacological effects on antioxidant, anti-inflammation, allergies, diabetes viral infections. Objective: Very little about potential activity fermented dried Citrus extracts (FCU) using Bacillus subtilis, as well its mechanism action. We investigated the FCU anti-inflammatory activities in murine macrophages moisturizing human keratinocytes. Materials methods: isolated subtilis...
We have isolated five furanocoumarins, byakangelicin, phellopterin, imperatorin, isoimperatorin, and oxypeucedanin methanolate, from the roots of Angelica dahurica (Umbelliferae) prepared semi-synthesized compounds by partial reduction each furanocoumarin, effects these on lipopolysaccharide (LPS)-induced prostaglandin E2 (PGE2) production in rat peritoneal macrophages were examined. Among compounds, imperatorin showed most potent inhibitory activity LPS-induced PGE2 production. It also...
To characterize active principles for prevention and treatment of diabetic complications, the isolation protein glycation inhibitors from fruiting body Phellinus linteus was conducted in vitro using model systems hemoglobin-delta-gluconolactone (early stage), bovine serum albumin-methylglyoxal (middle N(alpha)-acetyl-glycyl-lysine methyl ester-D-ribose (last stage) assays. Nine compounds were isolated ethylacetate fraction identified as protocatechuic acid (1), protocatechualdehyde (2),...
In an effort to characterize active principles for diabetic complication from medicinal mushroom, aldose reductase inhibitors were isolated the fruiting body of Phellinus linteus and identified as hispidin (5), phelligridimer A (6), davallialactone (7), methyldavallialactone (8), hypholomine B (9), interfungins (10), inoscavin (11), together with protocatechuic acid (1), protocatechualdehyde (2), caffeic (3), ellagic (4). Their structures elucidated by spectroscopic analyses. Among them, (4)...
To examine the function of SIRT1 in neuronal differentiation, we employed all‐trans retinoic acid (ATRA)‐induced differentiation neuroblastoma cells. Nicotinamide inhibited neurite outgrowth and tyrosine hydroxylase (TH) expression. Inhibition PARP or histone deacetylase did not inhibit TH expression, showing effect to be specific. Expression FOXO3a its target proteins were increased during reduced by nicotinamide. deacetylation was ATRA blocked siRNA ATRA‐induced up‐regulation...
Aldose reductase (AR) inhibitors have a considerable therapeutic potential against diabetes complications and do not increase the risk of hypoglycemia. Through bioassay-guided fractionation an EtOH extract kernel from purple corn ( Zea mays L.), 7 nonanthocyanin phenolic compounds (compound 1–7 ) 5 anthocyanins 8–12 were isolated. These investigated by rat lens aldose (RLAR) inhibitory assays. Kinetic analyses recombinant human (rhAR) performed, intracellular galactitol levels measured....
Tyrosinase inhibitors are of far-ranging importance in cosmetics, medicinal products, and food industries. Peru is a diverse country with wide variety plants that may contain excellent anti-tyrosinase inhibitors. In the present study, tyrosinase inhibitory properties 50 plant extracts from were investigated using assay. Among extracts, those showed an inhibition rate >50% Hypericum laricifolium Juss., Taraxacum officinaleF.H.Wigg., Muehlenbeckia vulcanicaMeisn., H. Juss. showing greatest...
The aim of this study was to determine aldose reductase (AR) inhibitory activity and 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging compounds from Agrimonia pilosa Ledeb (AP). We isolated agrimoniin (AM), four flavonoid glucosides two glucuronides the n-butanol fraction AP 50% methanol extract. In addition compounds, AR-inhibitory DPPH catechin, 5-flavonoids, 4-flavonoid (known components AP) against rat lens AR (RLAR) assay were measured. AM showed IC50 values 1.6 13.0 μM RLAR...
In this study, the anti-adipogenetic activity of 300 plant extracts was investigated using an Oil Red O staining assay in a 3T3-L1 cell line. Our results indicate that three plants, including stem and leaf Physalis angulata, whole grass Solidago virgaurea, root Dioscorea nipponica, produced over 90% inhibition adipogenesis. Kaempferol-3-O-rutinoside, which demonstrated 48.2% inhibitory effect on adipogenesis without cytotoxicity, isolated from butanol layer water extract S. virgaurea guided...