A5016926065- Neuroinflammation and Neurodegeneration Mechanisms
- Food Quality and Safety Studies
- Radiation Effects and Dosimetry
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neuropharmacology Research
- Neurological Disease Mechanisms and Treatments
- Pharmacological Effects of Natural Compounds
- Medicinal Plants and Neuroprotection
- Natural product bioactivities and synthesis
- Phytochemicals and Antioxidant Activities
- Biochemical effects in animals
- Nutrition, Health and Food Behavior
- Natural Antidiabetic Agents Studies
- Anesthesia and Neurotoxicity Research
- Phytoestrogen effects and research
- GABA and Rice Research
- Adipokines, Inflammation, and Metabolic Diseases
- Aldose Reductase and Taurine
- Agriculture, Soil, Plant Science
- Seaweed-derived Bioactive Compounds
- Adipose Tissue and Metabolism
- Ginseng Biological Effects and Applications
- Silymarin and Mushroom Poisoning
- Advanced Glycation End Products research
- Phytochemistry and Biological Activities
Hallym University
2016-2025
Ewha Womans University
2017-2021
Hallym Polytechnic University
2007-2018
Kangwon National University
2017
Hallym University Medical Center
2008-2015
Seoul National University
2002-2013
Food and Nutrition Service
2007-2008
Chonnam National University
2008
Kyoto University
1993-1998
Kyoto Bunkyo University
1993-1998
Chlorogenic acid (CGA), an ester of caffeic and quinic acid, is among the phenolic compounds which can be naturally found in green coffee extract tea. CGA has been studied since it displays significant pharmacological properties. The aim this study was to investigate effects on cognitive function neuroprotection including its mechanisms hippocampus following transient forebrain ischemia gerbils. Memory learning investigated by eight-arm radial maze passive avoidance tests. Neuroprotection...
Fruits of bog blueberry (Vaccinium uliginosum L.) are rich in anthocyanins that contribute pigmentation. Anthocyanins have received much attention as agents with potentials preventing chronic diseases. This study investigated the capacity anthocyanin-rich extract from (ATH-BBe) to inhibit photoaging UV-B-irradiated human dermal fibroblasts. BBe were detected cyanidin-3-glucoside, petunidin-3-glucoside, malvidin-3-glucoside, and delphinidin3-glucoside. ATH-BBe attenuated UV-B-induced toxicity...
Vascular endothelial growth factor (VEGF) is known as a key regulator of angiogenesis during endochondral bone formation. Recently, we demonstrated that TNF-related activation-induced cytokine (TRANCE or RANKL), which essential for remodeling, also had an angiogenic activity. Here report VEGF up-regulates expression receptor activator NF-κ B (RANK) and increases responses cells to TRANCE. Treatment human umbilical vein (HUVECs) with increased both RANK mRNA surface protein expression....
The antioxidant activities of the ethanol (EtOH) extracts from green seaweeds Enteromorpha compressa, Capsosiphon fulvescens, Chaetomorpha moniligera, and Ulva pertusa, as well their solvent-partitioned fractions, were investigated, correlated with total phenolic flavonoid contents. EtOH fractions showed 2,2-diphenyl-1-picrylhydrazyl (DPPH) hydroxyl (OH•) radical scavenging strong reducing ability. most effective properties observed E. compressa C. fulvescens. Among obtained n-hexane,...
Background. The positive correlation between therapeutic exercise and memory recovery in cases of ischemia has been extensively studied; however, long-term begun after ischemic neuronal death as a chronic neurorestorative strategy not yet thoroughly examined. Objective. purpose this study is to investigate possible mechanisms by which ameliorates ischemia-induced impairment the aged gerbil hippocampus transient cerebral ischemia. Methods. Treadmill was 5 days ischemia-reperfusion (I-R)...
Abstract Preconditioning by brief ischemic episode induces tolerance to a subsequent lethal insult, and it has been suggested that reactive oxygen species are involved in this phenomenon. Thioredoxin 2 (Trx2), small protein with redox‐regulating function, shows cytoprotective roles against oxidative stress. Here, we had focused on the role of Trx2 preconditioning (IPC)‐mediated neuroprotection stress followed transient cerebral ischemia. Animals used study were randomly assigned six groups;...
Quercetin (QE; 3,5,7,3',4'-pentahydroxyflavone), a well-known flavonoid, has been shown to prevent against neurodegenerative disorders and ischemic insults. However, few studies are reported regarding the neuroprotective mechanisms of QE after Therefore, in this study, we investigated effects on injury expression antioxidant enzymes hippocampal CA1 region gerbils subjected 5 minutes transient cerebral ischemia. was pre-treated once daily for 15 days before Pretreatment with protected...
Aucubin, an iridoid glycoside, possesses beneficial bioactivities in many diseases, but little is known about its neuroprotective effects and mechanisms brain ischemia reperfusion (IR) injury. This study evaluated whether aucubin exhibited against IR injury the hippocampal CA1 region through anti-inflammatory activity gerbils. Aucubin (10 mg/kg) was administered intraperitoneally once a day for one week prior to IR. Neuroprotective of were assessed by neuronal nuclei (NeuN)...
To characterize active principles for prevention and treatment of diabetic complications, the isolation protein glycation inhibitors from fruiting body Phellinus linteus was conducted in vitro using model systems hemoglobin-delta-gluconolactone (early stage), bovine serum albumin-methylglyoxal (middle N(alpha)-acetyl-glycyl-lysine methyl ester-D-ribose (last stage) assays. Nine compounds were isolated ethylacetate fraction identified as protocatechuic acid (1), protocatechualdehyde (2),...
In an effort to characterize active principles for diabetic complication from medicinal mushroom, aldose reductase inhibitors were isolated the fruiting body of Phellinus linteus and identified as hispidin (5), phelligridimer A (6), davallialactone (7), methyldavallialactone (8), hypholomine B (9), interfungins (10), inoscavin (11), together with protocatechuic acid (1), protocatechualdehyde (2), caffeic (3), ellagic (4). Their structures elucidated by spectroscopic analyses. Among them, (4)...
Onion has several well-known biological functionalities, including antioxidant effects, and contains quercetin (3,3′,4,5,7-pentahydroxyflavone), a powerful antioxidant. In the present study, we observed neuroprotective effects of onion extract (OE) its major component, quercetin, on ischemic damage in gerbil hippocampus, which is related to memory function. Repeated treatment with 100 mg/kg OE 20 for 15 days before surgery protected pyramidal neurons hippocampal CA1 region from damage....
Aldose reductase (AR) inhibitors have a considerable therapeutic potential against diabetes complications and do not increase the risk of hypoglycemia. Through bioassay-guided fractionation an EtOH extract kernel from purple corn ( Zea mays L.), 7 nonanthocyanin phenolic compounds (compound 1–7 ) 5 anthocyanins 8–12 were isolated. These investigated by rat lens aldose (RLAR) inhibitory assays. Kinetic analyses recombinant human (rhAR) performed, intracellular galactitol levels measured....
Abstract We investigated the probability of newly generated neurons that could survive and mature in ischemic hippocampal CA1 region (CA1) a gerbil model transient cerebral ischemia. Neuronal death was shown stratum pyramidale (SP) from 4 days post‐ischemia, significant increase NeuN‐positive ( + ) found SP at 180 post‐ischemia. 5‐Bromo‐2‐deoxyuridine (BrdU) cells were co‐stained with NeuN glutamic decarboxylase 67 (GAD67). Brain‐derived neurotrophic factor (BDNF) immunoreactivity protein...
Vascular dementia affects cognition by damaging axons and myelin. Melatonin is pharmacologically associated with various neurological disorders. In this study, effects of melatonin on cognitive impairment related mechanisms were investigated in an animal model ischemic vascular (IVD). was intraperitoneally administered to adult gerbils after transient global cerebral ischemia (tGCI) for 25 days beginning 5 tGCI. Cognitive examined using a passive avoidance test the Barnes maze test. To...
High levels of plasma low-density lipoprotein (LDL) cholesterol are an important determinant atherosclerotic lesion formation. The disruption efflux or reverse transport (RCT) in peripheral tissues and macrophages may promote atherogenesis. aim the current study was to examine whether bioactive ellagic acid, a functional food component, improved RCT functionality high-density (HDL) function diet-induced atherogenesis apolipoproteins E (apoE) knockout (KO) mice.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGelation and gel properties of soybean glycinin in a transglutaminase-catalyzed systemIl Jun Kang, Yasuki Matsumura, Koji Ikura, Masao Motoki, Hiroko Sakamoto, Tomohiko MoriCite this: J. Agric. Food Chem. 1994, 42, 1, 159–165Publication Date (Print):January 1994Publication History Published online1 May 2002Published inissue 1 January 1994https://pubs.acs.org/doi/10.1021/jf00037a028https://doi.org/10.1021/jf00037a028research-articleACS...
We recently reported that pyruvate inhibited translocation and activation of p53 caused by DNA damage due to oxidant injury (Lee YJ, Kang IJ, Bünger R, YH. Microvasc Res 66: 91-101, 2003); this was associated with increased expression apoptosis-related bcl-2 decreased bax gene. This study attempted delineate possible regulatory sites mechanisms antiapoptotic pyruvate, focusing on reactive oxygen species-mediated signaling in a human umbilical vein endothelial cell model. compared the effects...