A5074458765- Sirtuins and Resveratrol in Medicine
- Mitochondrial Function and Pathology
- Cancer, Hypoxia, and Metabolism
- Autophagy in Disease and Therapy
- DNA Repair Mechanisms
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Adipose Tissue and Metabolism
- FOXO transcription factor regulation
- Cancer Mechanisms and Therapy
- Cancer-related Molecular Pathways
- Telomeres, Telomerase, and Senescence
- Cardiac Arrhythmias and Treatments
- Cardiac tumors and thrombi
- Wound Healing and Treatments
- Cardiac Imaging and Diagnostics
- PARP inhibition in cancer therapy
- Infective Endocarditis Diagnosis and Management
- Dermatologic Treatments and Research
- Coronary Artery Anomalies
- MRI in cancer diagnosis
- Genetics, Aging, and Longevity in Model Organisms
- Endoplasmic Reticulum Stress and Disease
- Advanced X-ray and CT Imaging
Korea Institute of Toxicology
2017-2025
Korea Research Institute of Bioscience and Biotechnology
2024
Kafkas University
2024
Korea Institute of Oriental Medicine
2024
Northwestern University
2013-2023
Hallym University
2005-2021
Hallym University Kangnam Sacred Heart Hospital
2014-2021
Ewha Womans University Medical Center
1999-2019
Wonkwang University
2008-2018
Korea Center for Disease Control and Prevention
2018
Objectives: To present the pharmacokinetics and computed tomographic imaging efficacy of colloidal gold nanoparticles (AuNPs) as a blood-pool agent for x-ray tomography (CT). Methods Materials: prepare AuNPs, nanocrystals were modified using sulfhydrated polyethylene glycol (PEG). Cytotoxicity histopathologic tests carried out toxicity evaluation. Six adult Balb/c mice underwent microcomputed scans after injection AuNPs (2.5 μmol Au/g body weight). Four with HT-1080 tumors imaged...
Sirtuins connect energy generation and metabolic stress to the cellular acetylome. Currently, only mitochondrial sirtuins (SIRT3-5) SIRT1 have been shown direct function; however, Aims: NAD-dependent protein deacetylase sirtuin-2 (SIRT2), primary cytoplasmic sirtuin, is not yet reported associate with mitochondria.This study revealed a novel physiological function of SIRT2: regulation function. First, acetylation several proteins was found be altered in Sirt2-deficient mice, which was,...
SIRT2 is a cytoplasmic sirtuin that plays role in various cellular processes, including tumorigenesis, metabolism, and inflammation. Since these processes require iron, we hypothesized directly regulates iron homeostasis. Here, have demonstrated depletion results decrease levels both vitro vivo. Mechanistically, determined maintains by binding to deacetylating nuclear factor erythroid-derived 2-related 2 (NRF2) on lysines 506 508, leading reduction total NRF2 levels. The leads reduced...
Sirtuins participate in sensing nutrient availability and directing metabolic activity to match energy needs with production consumption. However, the pivotal targets for sirtuins cancer are mainly unknown. In this study, we identify M2 isoform of pyruvate kinase (PKM2) as a critical target sirtuin SIRT2 implicated cancer. PKM2 directs synthesis acetyl-CoA, latter which is transported mitochondria use Krebs cycle generate ATP. Enabled by shotgun mass spectrometry analysis founded on tissue...
Narcissists, who seek keenly to self-enhance, strive positively distinguish themselves. Might they therefore be inclined purchase consumer products that enable them do so? Study 1 found narcissism, but not self-esteem, predicted dispositions for the purpose of promoting personal uniqueness. Studies 2 and 3 narcissism greater interest in exclusive, customizable, personalizable products. also participants higher regarded their prized possessions as less likely owned by others. Finally, 4 a...
A new and simple synthetic strategy allows the direct introduction of phosphoric acid anchoring group carboxyl functional into polyethylene glycol (PEG), leading to strong binding iron oxide nanoparticle surfaces through bidentate or tridentate Fe–O–P coordination bonds, providing functionality for further conjugation targeting ligands. The carboxyl–PEG–phosphoric-acid-stabilized nanoparticles exhibited extremely high stability in various harsh aqueous environments. vivo magnetic resonance...
Sirtuin 2 (SIRT2) is a sirtuin family deacetylase that directs acetylome signaling, protects genome integrity, and murine tumor suppressor. We show SIRT2 replication stress responses by regulating the activity of cyclin-dependent kinase 9 (CDK9), protein required for recovery from arrest. deficiency results in sensitivity, impairment arrest, spontaneous accumulation A to foci chromatin, G2/M checkpoint deficit. interacts with deacetylates CDK9 at lysine 48 response manner partially dependent...
The isocitrate dehydrogenase IDH2 produces α-ketoglutarate by oxidizing isocitrate, linking glucose metabolism to oxidative phosphorylation. In this study, we report that loss of SIRT3 increases acetylation at lysine 413 (IDH2-K413-Ac), thereby decreasing its enzymatic activity reducing dimer formation. Expressing a genetic mimetic mutant (IDH2K413Q) in cancer cells decreased dimerization and increased cellular reactive oxygen species glycolysis, suggesting shift mitochondrial metabolism....
The ataxia telangiectasia-mutated and Rad3-related (ATR) kinase checkpoint pathway maintains genome integrity; however, the role of sirtuin 2 (SIRT2) acetylome in regulating this is not clear. We found that deacetylation ATR-interacting protein (ATRIP), a regulatory partner ATR, by SIRT2 potentiates ATR checkpoint. interacts with deacetylates ATRIP at lysine 32 (K32) response to replication stress. K32 drives autophosphorylation signaling facilitates DNA fork progression recovery stalled...
Textile wastewater accounts for a significant proportion of industrial worldwide.
Growing evidence suggests that the elevation of free fatty acids, including palmitic acid (PA), are associated with inflammation and oxidative stress, which may be involved in endothelial dysfunction, characterized by reduced bioavailability nitric oxide (NO) synthesized from NO synthase (eNOS). Heme oxygenase‑1 (HO‑1) is important preservation bioavailability. Piceatannol (Pic), similar chemical structure to resveratrol, suggested possess protective effects as resveratrol. In present study,...
To examine the function of SIRT1 in neuronal differentiation, we employed all‐trans retinoic acid (ATRA)‐induced differentiation neuroblastoma cells. Nicotinamide inhibited neurite outgrowth and tyrosine hydroxylase (TH) expression. Inhibition PARP or histone deacetylase did not inhibit TH expression, showing effect to be specific. Expression FOXO3a its target proteins were increased during reduced by nicotinamide. deacetylation was ATRA blocked siRNA ATRA‐induced up‐regulation...
Manganese superoxide dismutase (MnSOD) functions as a tumor suppressor; however, once tumorigenesis occurs, clinical data suggest MnSOD levels correlate with more aggressive human tumors, implying potential dual function of in the regulation metabolism. Here we show, using vitro transformation and xenograft growth assays that MnSOD-K68 acetylation (Ac) mimic mutant (MnSOD