A5100617552- Peptidase Inhibition and Analysis
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Liver physiology and pathology
- Cancer Research and Treatments
- PI3K/AKT/mTOR signaling in cancer
- Phytochemicals and Antioxidant Activities
- Sepsis Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Cancer, Lipids, and Metabolism
- Microtubule and mitosis dynamics
- Pancreatic and Hepatic Oncology Research
- Stroke Rehabilitation and Recovery
- Neurological Disease Mechanisms and Treatments
- Acupuncture Treatment Research Studies
- HER2/EGFR in Cancer Research
- Lung Cancer Treatments and Mutations
- Autophagy in Disease and Therapy
- Endometrial and Cervical Cancer Treatments
- Cardiac Valve Diseases and Treatments
- Natural product bioactivities and synthesis
- Attention Deficit Hyperactivity Disorder
- Mesenchymal stem cell research
- Pharmacological Effects of Natural Compounds
- Nanoparticle-Based Drug Delivery
Zhejiang Provincial People's Hospital
2025
Hangzhou Medical College
2025
Southern Medical University
2015-2024
Nanfang Hospital
2018-2024
Prince of Wales Hospital
2024
Chinese University of Hong Kong
2023-2024
Anyang Institute of Technology
2024
Third Affiliated Hospital of Southern Medical University
2015-2023
Zhujiang Hospital
2017-2023
Zhongda Hospital Southeast University
2023
Abstract The ubiquitous second messenger Ca2+ has long been recognized as a key regulator in cell migration. Locally confined Ca2+, particular, is essential for building front-to-rear gradient, which serves to maintain the morphologic polarity required directionally migrating cells. However, little known about source of and mechanism by they crosstalk between different signaling pathways cancer Here, we report that calcium release–activated modulator 2 (ORAI2), poorly characterized...
Neuroblastoma (NB) is the most common extracranial neoplasm in children. In NB, loss of p53 function largely due to cytoplasmic sequestration rather than mutation. Ubiquitin-conjugating enzyme E2 N (UBE2N), also known as Ubc13, an ubiquitin-conjugating that promotes formation monomeric results its translocation and subsequent function. Therefore, inhibition UBE2N may reactivate by promoting nuclear accumulation. Here, we show NSC697923, a novel inhibitor, exhibits potent cytotoxicity panel...
An anti-EGFR/Notch antibody limits acquired resistance to EGFR inhibitors and radiation by reducing tumor-initiating cell frequency.
Background Attention Deficit Hyperactivity Disorder (ADHD) is increasingly recognized as a major problem for children and their families in China. However, its influence on parental mental health has been seldom explored. Objective To examine the prevalence of attention deficit hyperactivity disorder community sample aged 6–13 years, extent to which it impacts health. Method Cross-sectional study primary school pupils (number = 2497) Deyang, Sichuan Province, South-West We used standardized...
Celosia argentea L., Amaranthaceae, is widely used as traditional medicine with a long history in China. It unique source of Semen Celosiae whose contributions include purging the hepatic pathogenic fire, improving eyesight, and treating other eye diseases. Over 79 compounds from this plant were isolated identified, mainly including saponins, peptides, phenols, fatty acids, amino which saponins have been considered characteristic active constituents argentea. Experimental evidences...
Aims The neutrophil–lymphocyte ratio (NLR) is a systemic reflection of cancer‐associated inflammation and prognostic marker for breast cancer. For the local tumour microenvironment, tumour‐infiltrating lymphocytes (TILs) tumour‐associated macrophages (TAMs) are also highly correlated with cancer survival. This study aimed to explore relationship between circulating immune further delineate role NLR in patients receiving neoadjuvant chemotherapy (NAC). Methods A cohort NAC subsequent surgery...
Abstract Introduction Mesenchymal stem cells (MSCs) are considered to play important roles in wound repair and tissue remodeling. Hypertrophic scar (HTS) is a cutaneous condition characterized by deposits of excessive amount collagen after an acute skin injury. However, currently there little knowledge about the direct relationship between MSCs HTS. Methods The hypertrophic model was established on rabbit ears. were isolated from femur bone marrow transplanted through ear artery injection....
Abstract: Trimetazidine (TMZ), a metabolic agent, may protect against myocardial ischemia/reperfusion injury. Because of the critical role autophagy in cardioprotection, we aimed to evaluate whether was involved TMZ-induced protection during hypoxia/reoxygenation (H/R). Neonatal rat cardiomyocytes were subjected H/R injury, and they divided into 7 groups: control, control+TMZ, control+chloroquine (Cq)/compound C (com C), H/R, H/R+TMZ, H/R+Cq/com C, H/R+TMZ+Cq/com C. Autophagic flux primarily...
Both EGFR and PI3K-Akt signaling pathways have been used as therapeutically actionable targets, but resistance is frequently reported. In this report, we show that enrichment of the cancer stem cell (CSC) subsets dysregulation Notch underlie challenges to therapy describe development bispecific antibodies targeting both HER signaling.We utilized cell-based models study in drug-induced CSC expansion. line patient-derived xenograft tumors were evaluate antitumor effects antibodies. Cell...
Resistance to radiotherapy is one of the main causes treatment failure in patients with nasopharyngeal carcinoma (NPC). Epstein-Barr virus (EBV) infection an important factor pathogenesis NPC, and EBV-encoded microRNAs (miRNAs) promote NPC progression. However, role miRNAs radiosensitivity remains unclear. Here, we investigated effects EBV-miR-BART8-3p on resistance cells vitro vivo, explored underlying molecular mechanisms. Inhibitors ataxia telangiectasia mutated (ATM)/ataxia Rad3-related...
Cardiac aging is characterized by myocardial hypertrophy, fibrosis, and diastolic dysfunction. Human kallikrein (hKLK1) protects against fibrosis in various pathogenic states. However, the effects of hKLK1 overexpression on cardiac aging-related underlying mechanisms remain unknown. Moreover, role regulating macrophage function leading to has not been investigated. Thus, this study, we determined explored through which regulated fibrosis. Echocardiographic measurements showed that caused...
Studies suggest that repetitive transcranial magnetic stimulation (rTMS) is effective for the treatment of depression and promotes repair white matter. This study aims to assess effectiveness rTMS in treating after basal ganglia ischaemic stroke examine whether such effects are related restoration matter integrity.Sixty-six participants will be recruited from Zhujiang Hospital, Nanfang Hospital Sichuan Bayi Rehabilitation randomised a 1:1 ratio receive active or sham addition routine...
The embryonic microenvironment is known to suppress the tumorigenic phenotype of aggressive cancer cells; however, effects microenvironments on stem cells have not been sufficiently explored due lack suitable model systems. In order study microenviornment, we developed a novel in vitro system for induction malignant transformation human epithelial-like (hEpSCs), involving co-cultivation and close contact hEpSCs with A375 melanoma cell line, together mutagen treatment dimethylbenzanthracene...
K-Ras is a well-studied oncogene, and its mutation frequently found in epithelial cancers like pancreas, lung, colorectal cancers. Cancer cells harboring mutations are difficult to treat due the drug resistance metastasis properties. stem (CSCs) believed major cause of chemotherapeutic responsible for tumor recurrence metastasis. But how affects CSCs inflammation not clear. Here, we compared two colon cancer cell lines, HCT-116 HT-29, with former being G13D mutant latter wildtype. We that...