A5102866186- Glioma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Meningioma and schwannoma management
- DNA Repair Mechanisms
- MicroRNA in disease regulation
- Angiogenesis and VEGF in Cancer
- Genomics and Chromatin Dynamics
- Seismology and Earthquake Studies
- Neuroblastoma Research and Treatments
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Seismic Imaging and Inversion Techniques
- Neurofibromatosis and Schwannoma Cases
- earthquake and tectonic studies
- Earthquake Detection and Analysis
- Cytokine Signaling Pathways and Interactions
- Intracranial Aneurysms: Treatment and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Head and Neck Surgical Oncology
- Metallic Glasses and Amorphous Alloys
- Brain Metastases and Treatment
- RNA Interference and Gene Delivery
- Physical Education and Training Studies
- Cerebrospinal fluid and hydrocephalus
- Adaptive Control of Nonlinear Systems
Hefei University of Technology
2024
Shanghai Jiao Tong University
2023
Fudan University
2007-2014
Huashan Hospital
2009-2014
State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation
2006
University of Michigan–Ann Arbor
2003
The marginal delineation of gliomas cannot be defined by conventional imaging due to their infiltrative growth pattern. Here we investigate the relationship between changes in glioma metabolism proton magnetic resonance spectroscopic ((1)H-MRSI) and histopathological findings order determine an optimal threshold value choline/N-acetyl-aspartate (Cho/NAA) that can used define extent spread.Eighteen patients with different grades were examined using (1)H-MRSI. Needle biopsies performed under...
Ionizing radiation is known to cause DNA damage, including single-strand and double-strand breaks (DSBs), the unrepair of particularly DSBs, may chromosome aberrations. Although etiology gliomas remains unclear, exposure ionizing has been identified as only established risk factor. We hypothesized that polymorphisms candidate genes involved in DSBs repair pathway contribute susceptibility glioma. used a haplotype-based approach investigate role 22 tagging single-nucleotide (tSNPs) XRCC5 ,...
Although the role of environmental risk factors in etiology gliomas remains to be elucidated, accumulative epidemiological evidence suggests that genetic factors, such as variants genes involved DNA repair, may also play an important role. LIG4 and XRCC4 are known form a complex functionally linked repair double-stranded breaks. To determine whether polymorphisms associated with susceptibility glioma there interactions between XRCC4, we conducted case-control study 771 patients 752...
Glioma is the most common primary brain tumor, yet high cost of diagnostic imaging has made early detection asymptomatic glioma a formidable challenge. Thus, development convenient, sensitive, and cost-effective strategy, such as enzyme-linked immunosorbent assay (ELISA) based on glioma-specific World Health Organization (WHO) grade-specific autoantibody serum markers, necessary. To this end, comparative proteomic analysis two-dimensional western blotting was carried out with sera patients...
Abstract In mammalian cells, X‐ray repair cross‐complementing group3 ( XRCC3 ) plays an important role in the DNA double‐strand breaks (DSBs) by homologous recombination. Genetic polymorphisms gene may potentially affect of DSBs and thus confer susceptibility to gliomas. this study, we used a haplotype‐based approach investigate whether 4 tagging single nucleotide are associated with risk gliomas 771 glioma patients 752 cancer‐free controls. Odds ratios (ORs) 95% confidence intervals (CIs)...
This paper formulates a class of generic optimal formation control problems for second-order multiagent systems, where agents are steered to achieve the determined by convex optimization problem with constraints and admissible range constraints. These determine geometric pattern limit formation, respectively. A algorithm based on primal-dual dynamics is proposed various requirements. Based Lyapunov stability theories, states system shown converge solutions. Moreover, an obstacle avoidance...
Abstract Malignant gliomas recur even after extensive surgery and chemo‐radiotherapy. Although a relatively novel chemotherapeutic agent, temozolomide (TMZ), has demonstrated promising activity against gliomas, the effects last only few months drug resistance develops thereafter in many cases. It been acknowledged that glioma cells respond to TMZ treatment by undergoing G2/M arrest, but not apoptosis. Here we demonstrate phase‐specific chemotherapy due cellular prion protein (PrPc) human...
Abstract Vascular endothelial growth factor A (VEGFA), one of the most predominant mediators pathologic angiogenesis, plays a critical role in glioma carcinogenesis and development via promoting tumor growth. We hypothesized that VEGFA polymorphisms may influence risk. recently genotyped 9 single‐nucleotide (SNPs) 766 patients 824 cancer‐free controls selected from Chinese population. evaluated risk conferred by individual SNPs, haplotypes as well cumulative SNP effect. In single‐locus...
Glioma is the primary tumor in central nervous system, and poses one of greatest challenges clinical treatment. MIB-1 p53 are most useful biomarkers for gliomas could help neurosurgeons establish a therapeutic schedule. However, these commonly detected with immunohistochemistry (IHC), which wastes time energy often influenced by subjective factors. To reduce factors improve efficiency judgment IHC, novel magnetic resonance image (MRI) analysis method proposed present study to detect...
Abstract The effect of polyphenylene sulfide binder content on the properties injection molding sulfide/NdFeB magnets were investigated. maximum filling amount NdFeB magnetic powder was 87.6 wt.‐%, and mixing process subsequent in good condition. melt mass‐flow rate granular materials reached 121.7 g/10 min, compressive strength magnet 92.18 MPa, its energy product 5.59 MGOe. structure morphology characteristics investigated using scanning electron microscopy atomic force microscopy....