A5018483840- Meningioma and schwannoma management
- Vascular Malformations Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Brain Metastases and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Cerebral Venous Sinus Thrombosis
- Cancer-related molecular mechanisms research
- Lung Cancer Diagnosis and Treatment
- MicroRNA in disease regulation
- Pituitary Gland Disorders and Treatments
- Atomic and Subatomic Physics Research
- Lung Cancer Research Studies
- Neurogenesis and neuroplasticity mechanisms
- Parasitic infections in humans and animals
- Adenosine and Purinergic Signaling
- Radiation Therapy and Dosimetry
- Medical Imaging Techniques and Applications
- Spinal Fractures and Fixation Techniques
- MRI in cancer diagnosis
- Multiple Myeloma Research and Treatments
- Circular RNAs in diseases
- Immune cells in cancer
- Ubiquitin and proteasome pathways
- Advanced X-ray and CT Imaging
Huashan Hospital
2010-2025
Fudan University
2010-2025
Shanghai Chest Hospital
2024
Chinese Academy of Sciences
2024
University of California, San Francisco
2011
Background Falcine sinuses can remain persistent after birth, but they also become recanalized in cases where venous are invaded by meningiomas. Purpose To explore the incidence and imaging features of falcine healthy individuals parasagittal meningioma (PSM) patients on magnetic resonance venography (MRV). Material Methods Radiologists evaluated data 168 PSM patients. The invasion extent superior sagittal sinus (SSS) PSMs was confirmed a neurosurgeon based Sindou's criteria. We compared...
Abstract Malignant gliomas recur even after extensive surgery and chemo‐radiotherapy. Although a relatively novel chemotherapeutic agent, temozolomide (TMZ), has demonstrated promising activity against gliomas, the effects last only few months drug resistance develops thereafter in many cases. It been acknowledged that glioma cells respond to TMZ treatment by undergoing G2/M arrest, but not apoptosis. Here we demonstrate phase‐specific chemotherapy due cellular prion protein (PrPc) human...
Yaodong Ding, Yu Ge, Daijun Wang, Qin Liu, Shuchen Sun, Lingyang Hua, Jiaojiao Deng, Shihai Luan, Haixia Cheng, Qing Xie, Ye Gong, and Tao Zhang. Mol. Cells 2022;45:388-402. https://doi.org/10.14348/molcells.2022.2232
Objective Adjuvant radiotherapy is the main treatment modality for high grade meningioma after surgical resection; however, recurrence and survival outcomes vary. The aim of this study was to create a new “prognostic score” that allows personalized recommendations post-operative adjuvant in patients with meningioma. Methods Clinical data were collected from 115 treated resection radiotherapy. A prognostic model built based on hazards ratios independent factors yielded by multivariate cox...
Meningioma is one of the most common primary neoplasms in central nervous system, but no specific molecularly targeted therapy has been approved for clinical treatment aggressive meningiomas. There hence an urgent demand to decrypt biological and molecular landscape malignant meningioma. Here, through in-silica prescreening 10-year follow-up studies 445 meningioma patients, we uncovered that CBX7 expression progressively decreases with malignancy grade neoplasia stage meningioma, a high...
Objective: This study aims to evaluate the potential role of 18 F-fluorodeoxyglucose positron emission tomography ( F-FDG PET) in detecting high-grade meningiomas and predicting prognosis patients after meningioma surgery. Patients methods: A total 124 met final inclusion criterion. Tumor gray ratio (TGR) was compared with Ki-67 labeling index, its correlations pre-operative neurological function treatment status were also evaluated. Receiver-operating characteristic (ROC) curve drawn...
Background: Resection of meningioma located at primary motor cortex (PMC) is a great challenge to neurosurgeons due the possibility injury and drainage venous damage during surgery. Here, we presented our experience in resection PMC meningioma, with assistance preoperative multi-model image planning intraoperative electrophysiological monitor. By these techniques, patients study achieved gross tumor (GTR) appropriate protection, recovered well less neurologic deficits.Methods: Thirty were...
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Abstract The epidermal growth factor receptor (EGFR) mutation exists in approximately 50% of patients with lung adenocarcinoma and is crucial for predicting response to targeted therapies. An increasing number have brain metastases (BMs) at diagnosis or later develop BMs. study aimed establish a non-invasive radiomics model distinguishing EGFR status BMs investigating the predictive performance four MR sequences. 122 diagnosed (57 mutant 65 wild-type patients) were enrolled study. 960...
Background:: Some patients with suspected brain metastases (BM) could not tolerate longer scanning examinations according to the standardized MRI protocol. Objective:: The purpose of this study was evaluate clinical value contrast-enhanced fast fluid-attenuated inversion recovery (CE FLAIR) imaging in combination T1 weighted T1WI) detecting BM lung cancer and explore a quick effective Material Methods:: In 201 cancers BM, T1WI FLAIR were performed before after administration gadopentetate...
Early recognition of sinus invasion for meningiomas matters the clinical intervention. Therefore, we retrospectively investigated relationship between peritumoral vessel features on magnetic resonance venography (MRV) and status.
The pathological sub-classification of lung cancer is crucial in diagnosis, treatment and prognosis for patients. Quick timely identification subtypes from imaging examinations rather than histological tests could help guiding therapeutic strategies. aim the study to construct a non-invasive radiomics-based model predicting on brain metastases (BMs) multiple magnetic resonance (MRI) sequences. One hundred sixty-one patients primary with synchronous BMs [121 adenocarcinoma (AD); 40 small cell...
Purpose: Kernel-based dynamic dose painting was introduced at the 2010 AAPM meeting. The purpose of this study to investigate a practical treatment planning and delivery approach with current technology potential dosimetric advantages on 3D patient anatomy for such an approachMethods: For delivery, kernel (i.e., paintbrush) is first formed from high number converging beams, then transverses (i.e. paint) continuously throughout target volume create desired distribution. In study, we employed...
Abstract Purpose To evaluate the clinical value of contrast-enhanced fast fluid-attenuated inversion recovery (CE FLAIR) imaging in combination with T1 weighted T1WI) detecting cranial metastases lung cancers. Methods In 201 patients known cancers and suspected metastases, T1WI FLAIR were performed before after administration gadopentetate dimeglumine. Two radiologists reviewed pre- post-contrast images to determine presence abnormal contrast enhancement or signal intensity, decided whether...