A5069136110- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pregnancy and preeclampsia studies
- Reproductive System and Pregnancy
- Neonatal Respiratory Health Research
- Preterm Birth and Chorioamnionitis
- Prenatal Screening and Diagnostics
- RNA modifications and cancer
- Birth, Development, and Health
- Respiratory Support and Mechanisms
- Renal and Vascular Pathologies
- Asthma and respiratory diseases
- Fetal and Pediatric Neurological Disorders
- Cancer-related molecular mechanisms research
- IL-33, ST2, and ILC Pathways
- RNA Research and Splicing
- Delphi Technique in Research
- MRI in cancer diagnosis
- Assisted Reproductive Technology and Twin Pregnancy
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Epigenetics and DNA Methylation
- Pediatric health and respiratory diseases
- Congenital Anomalies and Fetal Surgery
- Advanced X-ray and CT Imaging
- Cleft Lip and Palate Research
- Salivary Gland Disorders and Functions
Brigham and Women's Hospital
2018-2025
Harvard University
2018-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2012-2024
National Institutes of Health
2012-2024
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2012-2024
United States Department of Health and Human Services
2012-2024
Peking Union Medical College Hospital
2012-2024
Nanjing Medical University
2018
BGI Group (China)
2018
Nanjing Maternity and Child Health Care Hospital
2018
Preeclampsia is a disease of the mother, fetus and placenta, gaps in our understanding complex interactions among their pathways withheld successful treatment prevention. The placenta has key role pathogenesis terminal pathway characterized by exaggerated maternal systemic inflammation, generalized endothelial damage, hypertension proteinuria. This sine qua non preeclampsia may be triggered distinct underlying mechanisms that occur at early stages pregnancy induce different phenotypes. To...
Abstract Decidual macrophages are implicated in the local inflammatory response that accompanies spontaneous preterm labor/birth; however, their role is poorly understood. We hypothesized decidual undergo a proinflammatory (M1) polarization during labor and PPARγ activation via rosiglitazone (RSG) would attenuate macrophage-mediated response, preventing birth. In this study, we show that: 1) an M1-like term labor; 2) anti-inflammatory (M2)-like more abundant than tissue; 3) M2-like reduced...
Identifying the pathways that are significantly impacted in a given condition is crucial step understanding underlying biological phenomena. All approaches currently available for this purpose calculate P -value aims to quantify significance of involvement each pathway phenotype. These -values were previously thought be independent. Here we show not case, and many can considerably affect other's through “crosstalk” phenomenon. Although it intuitive various could influence other, presence...
Abstract Recent studies indicate that clinical chorioamnionitis is a heterogeneous condition and only approximately one-half of the patients have bacteria in amniotic cavity, which often associated with intra-amniotic inflammation. The objective this study to characterize nature inflammatory response within cavity at term according presence or absence 1) 2) A retrospective cross-sectional case-control was conducted examine cytokine chemokine concentrations fluid (AF). Cases consisted women...
Problem Inflammasomes are signaling platforms that, upon sensing pathogens and sterile stressors, mediate the release of mature forms interleukin ( IL )‐1β ‐18. The aims this study were to determine (i) expression major inflammasome components in chorioamniotic membranes spontaneous labor at term, (ii) whether there changes associated with activation caspase‐1 caspase‐4, (iii) these events ‐1β Method Chorioamniotic collected from women term without labor. mRNA abundance protein...
Identification of COPD disease-causing genes is an important tool for understanding why develops, who at highest risk, and how new treatments can be developed. Previous genetic studies have identified a highly significant association near nephronectin (NPNT), gene involved in tissue repair, but the biological mechanisms underlying this are unknown. Splicing quantitative trait locus analysis (sQTL) was performed to identify common variants that alter RNA splicing lung tissues. These sQTL...
SM22 (or transgelin), an actin-binding protein abundant in vascular smooth muscle cells (VSMCs), is downregulated atherosclerosis, aneurysm and various cancers. Abolishing apolipoprotein E knockout mice accelerates atherogenesis. However, it unclear whether disruption independently promotes arterial inflammation.To investigate directly inflammation on injury to characterize the underlying mechanisms.Using carotid denudation as artery model, we showed that Sm22 (Sm22(-/-)) developed enhanced...
Lipid mediators play an important role in reproductive biology, especially, parturition. Enhanced biosynthesis of eicosanoids, such as prostaglandin E2 (PGE2) and PGF2α, precedes the onset labor a result increased expression inducible cyclooxygenase 2 (COX-2) placental tissues. Metabolism arachidonic acid results bioactive lipid beyond prostaglandins that could significantly influence myometrial activity. Therefore, unbiased lipidomic approach was used to profile metabolome amniotic fluid....
Abstract Preterm birth (PTB) is the leading cause of neonatal morbidity and mortality worldwide. Although intra-amniotic infection a recognized spontaneous preterm labor, noninfection-related etiologies are poorly understood. In this article, we demonstrated that expansion activated CD1d-restricted invariant NKT (iNKT) cells in third trimester by administration α-galactosylceramide (α-GalCer) induced late PTB mortality. vivo imaging revealed fetuses from mice underwent α-GalCer–induced had...
Abstract Fever is a major criterion for clinical chorioamnionitis; yet, many patients with intrapartum fever do not have demonstrable intra-amniotic infection. Some cytokines, such as interleukin (IL)-1, IL-6, interferon-gamma (IFN-γ), and tumor necrosis factor alpha (TNF-α), can induce fever. The objective of this study was to determine whether maternal plasma concentrations cytokines could be value in the identification diagnosis chorioamnionitis at term who microbial-associated...
Ionizing radiation is known to cause DNA damage, including single-strand and double-strand breaks (DSBs), the unrepair of particularly DSBs, may chromosome aberrations. Although etiology gliomas remains unclear, exposure ionizing has been identified as only established risk factor. We hypothesized that polymorphisms candidate genes involved in DSBs repair pathway contribute susceptibility glioma. used a haplotype-based approach investigate role 22 tagging single-nucleotide (tSNPs) XRCC5 ,...
Abstract Microbial invasion of the fetus due to intra-amniotic infection can lead a systemic inflammatory response characterized by elevated concentrations cytokines in umbilical cord plasma/serum. Clinical chorioamnionitis represents maternal syndrome often associated with infection, although other causes this have been recently described. The objective study was characterize plasma cytokine profile neonates born mothers clinical at term, according presence or absence bacteria and/or...
Objectives To assess the value of single and serial fetal biometry for prediction small- (SGA) large-for-gestational-age (LGA) neonates delivered preterm or at term. Methods A cohort study 3,971 women with singleton pregnancies was conducted from first trimester until delivery 3,440 (17,334 scans) meeting following inclusion criteria: 1) a live neonate after 33 gestational weeks 2) two more ultrasound examinations parameters obtained ≤36 weeks. Primary outcomes were SGA (<5th centile) LGA...
Clinical chorioamnionitis at term (TCC) is the most common obstetrical infliction diagnosed in labor and delivery units worldwide associated with a substantial increase maternal neonatal morbidity mortality. This complication heterogeneous condition, as only half of patients have detectable microorganisms amniotic cavity. Because bioactive lipids play key role initiation resolution an inflammatory response, we aimed to characterize fluid lipidome TCC. We studied following groups: 1)...
Development of maternal blood transcriptomic markers to monitor placental function and risk obstetrical complications throughout pregnancy requires accurate quantification gene expression. Herein, we benchmark three state-of-the-art expression profiling techniques assess in circulation the cell type-specific sets previously discovered by single-cell genomics studies placenta. We compared Affymetrix Human Transcriptome Arrays, Illumina RNA-Seq, sequencing-based targeted (DriverMapTM) changes...
The routine assessment to determine the genetic etiology for fetal ultrasound anomalies follows a sequential approach, which usually takes about 6–8 weeks turnaround time (TAT). We evaluated clinical utility of simultaneous detection copy number variations (CNVs) and single nucleotide variants (SNVs)/small insertion-deletions (indels) in fetuses with normal karyotype anomalies. performed CNV by chromosomal microarray analysis (CMA) or low pass CNV-sequencing (CNV-seq), parallel SNVs/indels...
Acute exacerbations of chronic obstructive pulmonary disease (AE-COPDs) are associated with a significant burden. Blood immune phenotyping may improve our understanding COPD endotype at increased risk exacerbations.
Although the role of environmental risk factors in etiology gliomas remains to be elucidated, accumulative epidemiological evidence suggests that genetic factors, such as variants genes involved DNA repair, may also play an important role. LIG4 and XRCC4 are known form a complex functionally linked repair double-stranded breaks. To determine whether polymorphisms associated with susceptibility glioma there interactions between XRCC4, we conducted case-control study 771 patients 752...
Bioactive lipids derived from the metabolism of polyunsaturated fatty acids are important mediators inflammatory response. Labor per se is considered a sterile process. Intra-amniotic inflammation (IAI) due to microorganisms (i.e., intra-amniotic infection) or danger signals IAI) has been implicated in pathogenesis preterm labor and clinical chorioamnionitis at term. Early accurate diagnosis microbial invasion amniotic cavity (MIAC) requires analysis fluid (AF). It possible that IAI caused...
Problem To characterize the amniotic fluid ( AF ) inflammatory‐related protein IRP network in patients with a sonographic short cervix SC x) and to determine its relation early preterm delivery ePTD ). Method of study A retrospective cohort included women x (≤25 mm; n=223) who had amniocentesis were classified according gestational age GA at diagnosis <32 weeks gestation). Results (i) In ≤ 22 1/7 weeks, concentration most s increased as shortened; those higher rate increase MIP ‐1α, MCP...