A5015000868- Neonatal Respiratory Health Research
- Immune Cell Function and Interaction
- GDF15 and Related Biomarkers
- Preterm Birth and Chorioamnionitis
- Mitochondrial Function and Pathology
- Infant Nutrition and Health
- Reproductive System and Pregnancy
Wayne State University
2014-2016
Sportska Akademija Beograd
1998
Abstract Preterm birth (PTB) is the leading cause of neonatal morbidity and mortality worldwide. Although intra-amniotic infection a recognized spontaneous preterm labor, noninfection-related etiologies are poorly understood. In this article, we demonstrated that expansion activated CD1d-restricted invariant NKT (iNKT) cells in third trimester by administration α-galactosylceramide (α-GalCer) induced late PTB mortality. vivo imaging revealed fetuses from mice underwent α-GalCer–induced had...
Abstract Objective: Maternal-fetal tolerance involves a tight balance between the innate and adaptive immunity, which avoids rejection of semi-allogeneic embryo. The limbs immune response are bridged by iNKT cells; therefore, we hypothesized that an alteration in their number and/or activation breaks maternal-fetal tolerance, leading to premature delivery. Methods: Pregnant mice were injected on E16.5 with either α-galactosylceramide (an activator; 2 μg) or PBS as control (n=19 each)....