A5101553058- Cancer-related molecular mechanisms research
- Metabolism, Diabetes, and Cancer
- Mesenchymal stem cell research
- Ferroptosis and cancer prognosis
- Nanoparticles: synthesis and applications
- Neonatal Health and Biochemistry
- Genomics and Chromatin Dynamics
- Central Venous Catheters and Hemodialysis
- Cancer Genomics and Diagnostics
- Renal cell carcinoma treatment
- Ubiquitin and proteasome pathways
- Renal and related cancers
- Colorectal Cancer Screening and Detection
- Cancer Cells and Metastasis
- Cancer-related gene regulation
- Gastric Cancer Management and Outcomes
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- PI3K/AKT/mTOR signaling in cancer
- Endometrial and Cervical Cancer Treatments
- Muscle Physiology and Disorders
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Neonatal and Maternal Infections
- Inflammatory Biomarkers in Disease Prognosis
Harbin Medical University
2024
Second Affiliated Hospital of Harbin Medical University
2024
Xijing Hospital
2020-2023
Children's Hospital of Zhejiang University
2020-2023
Air Force Medical University
2020-2023
Hebei General Hospital
2017-2022
Taizhou University
2020-2022
Chongqing Medical University
2017-2021
Taizhou Second People's Hospital
2020
Second Military Medical University
2013-2019
Abstract Genetically engineered T cells expressing a chimeric antigen receptor (CAR) are rapidly emerging promising new treatment for haematological and non-haematological malignancies. CAR-T therapy can induce rapid durable clinical responses but is associated with unique acute toxicities. Moreover, vulnerable to immunosuppressive mechanisms. Here, we report that release extracellular vesicles, mostly in the form of exosomes carry CAR on their surface. The CAR-containing express high level...
An anti-EGFR/Notch antibody limits acquired resistance to EGFR inhibitors and radiation by reducing tumor-initiating cell frequency.
Nidogen-1 (NID1) has been identified as a novel candidate diagnostic biomarker of ovarian cancer in our previous study. Nevertheless, the role NID1 pathogenesis is unclear. In present study, we demonstrated that was mesenchymal associated gene and its high expression significantly correlated with shorter overall survival patients. The ectopic OVCAR-3 cells revealed epithelial-mesenchymal transition (EMT) phenotype accompanied by enhancement motility, invasiveness cisplatin resistance,...
B-Myb is a transcription factor that overexpressed and plays an oncogenic role in several types of human cancers. However, its potential implication lung cancer remains elusive. In the present study, we have for first time investigated expression profile functional impact cancer. Expression analysis by quantificational real-time polymerase chain reaction (qRT-PCR) immunohistochemistry demonstrated aberrantly non-small cell (NSCLC), positively correlated with pathologic grade clinical stage...
Abstract Background Diabetic nephropathy (DN) is one of the most common and serious complications diabetes, important cause death for diabetic patients. Baicalin (BAI) has anti-oxidative, anti-inflammatory anti-apoptotic activities, which play a role in attenuating insulin resistance protecting kidney. Moreover, cell-specific targeting renal tubular cells an approach to enhance drug accumulation Methods Forty-five Sprague-Dawley rats were divided into four groups. A diabetes model was...
The aim of the current study was to investigate regulatory effect miR-146a on toll-like receptor 4 (TLR-4)/NF-κB pathway and therefore inflammation in septic cardiomyopathy. A total 60 healthy male Sprague Dawley rats were equally divided into a control, LPS, agonist inhibitor group. Blood samples collected from 24 h after intraperitoneal lipopolysaccharide injection myocardial tissues subsequently collected. After hematoxylin eosin staining rat tissues, degree inflammatory cell infiltration...
B-Myb has been shown to play an important oncogenic role in several types of human cancers, including non-small-cell lung cancer (NSCLC). We previously found that is aberrantly upregulated NSCLC, and overexpression can significantly promote NSCLC cell growth motility. In the present study, we have further investigated therapeutic potential NSCLC. Kaplan–Meier Cox proportional hazards analysis indicated high expression associated with poor prognosis patients. A loss-of-function study...
Both EGFR and PI3K-Akt signaling pathways have been used as therapeutically actionable targets, but resistance is frequently reported. In this report, we show that enrichment of the cancer stem cell (CSC) subsets dysregulation Notch underlie challenges to therapy describe development bispecific antibodies targeting both HER signaling.We utilized cell-based models study in drug-induced CSC expansion. line patient-derived xenograft tumors were evaluate antitumor effects antibodies. Cell...
Abstract B-Myb is an important transcription factor that plays a critical role in gene expression regulation and tumorigenesis. However, its functional implication colorectal cancer remains elusive. In this study, we found was significantly upregulated at both mRNA protein levels samples compared to non-tumor counterparts. overexpression accelerated cell proliferation, cycle progression motility cells, promoted tumor growth orthotopic nude mouse models vivo. contrast, depletion inhibited...
Abstract Background Globally, 1 in 11 adults have diabetes mellitus, and 90% of the cases are type 2 mellitus. Insulin resistance is a central defect although multiple drugs been developed to ameliorate insulin resistance, limitations accompanying side effects cannot be ignored. Thus, more effective methods required improve resistance. Methods In current study, db/m db/db mice were injected with human umbilical cord-derived mesenchymal stem cells (HUC-MSCs) via tail vein injection,...
Titanium dioxide nanoparticles (TiO 2 NPs) are massively produced and widely used in daily life, which may pose potential risk to human health via uncharacterized interaction between DNAs. This research aims examine the DNA three types of TiO NPs different sizes crystallines. The liver molecules obtained from Sprague-Dawley rats was systematically evaluated vivo using atomic force microscopy, transmission electron various spectroscopic techniques gel electrophoresis. We found that (diameter...
Parasites interact with their host through "direct" and/or "indirect" mechanisms. Plasmodium, for example, either mediates direct physical interactions factors or triggers the immune system of indirectly, leading to changes in infectious outcomes. Long non-coding RNAs (lncRNAs) participate regulating biological processes, especially host-pathogen interactions. However, research on role lncRNAs during Plasmodium infection is limited. A RNA sequencing method (RNA-seq) was used confirm...
Growing evidence has demonstrated that transforming acidic coiled-coil protein 3 (TACC3), a member of the TACC family, may be involved in regulating cell mitosis, transcription, and tumorigenesis. However, role TACC3 kidney renal clear carcinoma (KIRC) remains unknown. In this study, multiple databases were used to determine pattern KIRC. We found high expression was associated with poor overall survival (OS) stage I, II, IV grade KIRC patients. Univariate multivariate Cox regression...
To explore correlations between body mass index (BMI), preoperative systemic immune-inflammation (SII) and endocrine therapy resistance, evaluate BMI SII as predictors of in patients with luminal breast cancer.
Liver hepatocellular carcinoma (LIHC) is one of the most lethal tumors worldwide, and while its detailed mechanism occurrence remains unclear, an early diagnosis LIHC could significantly improve 5-years survival patients. It therefore imperative to explore novel molecular markers for develop efficient therapies Currently, DEPDC1B has been reported participate in regulation cell mitosis, transcription, tumorigenesis. To valuable diagnostic prognostic further elucidate mechanisms underlying...
Hydroquinone (HQ) is one of the most frequently used and effective skin-lightening products to treat skin hyperpigmentation disorders, including postinflammatory hyperpigmentation, melasma solar lentigines. HQ also widely in cosmetic for whitening. However, treatment can evoke substantial irritation, a side effect that remains poorly understood. Here we demonstrate an activator peripheral irritant receptor transient potential (TRP) cation channel member A1 (TRPA1). failed activate TRPV1,...
N-myc downstream-regulated gene 2 (NDRG2) and estrogen receptor beta (ERβ) both play key roles in cellular differentiation colorectal cancer (CRC). Previous studies have demonstrated that ERβ co-locates with directly transactivates NDRG2. However, the effect of NDRG2 on its underlying mechanism remain largely unknown. Our aim study is to explore their contributions progression CRC.The Cancer Genome Atlas (TCGA) database was first utilized validate clinical significance CRC. MTT scratch...
Background Epicutaneo-cava catheter (ECC) is an ideal venous access for very low birth weight (VLBW) infants. However, because veins of VLBW infants are thin, ECC difficult to insert, and the success rate puncture low. This study aimed use with 24G indwelling needles improve outcomes Methods retrospective enrolled 121 (birthweight <1,500 g) who required catheterization were admitted Neonatal Intensive Care Unit Children's Hospital Zhejiang University School Medicine between January...