A5083624959- Ion Channels and Receptors
- Biochemical Analysis and Sensing Techniques
- Smoking Behavior and Cessation
- Nicotinic Acetylcholine Receptors Study
- Olfactory and Sensory Function Studies
- Ion channel regulation and function
- Neurobiology and Insect Physiology Research
- Phytochemicals and Antioxidant Activities
- Pain Mechanisms and Treatments
- Essential Oils and Antimicrobial Activity
- Advanced Chemical Sensor Technologies
- Respiratory and Cough-Related Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Herbal Medicine Research Studies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Heart Rate Variability and Autonomic Control
- Neuropeptides and Animal Physiology
- Insect and Pesticide Research
- Occupational exposure and asthma
- Synthesis and Biological Evaluation
- Obesity, Physical Activity, Diet
- Air Quality and Health Impacts
- Neuroscience and Neuropharmacology Research
- Neuroscience of respiration and sleep
- Consumer Attitudes and Food Labeling
Duke University
2016-2025
Yale University
2010-2025
Duke Medical Center
2016-2024
Figshare (United Kingdom)
2024
Centre for Innovation in Regulatory Science
2023
Duke University Health System
2020
American Heart Association
2020
Virginia Commonwealth University
2020
University of Louisville
2020
The University of Sydney
2020
Garlic belongs to the Allium family of plants that produce organosulfur compounds, such as allicin and diallyl disulfide (DADS), which account for their pungency spicy aroma. Many health benefits have been ascribed extracts, including hypotensive vasorelaxant activities. However, molecular mechanisms underlying these effects remain unknown. Intriguingly, DADS share structural similarities with allyl isothiocyanate, pungent ingredient in wasabi other mustard induces pain inflammation by...
The capsaicin (vanilloid) receptor, VR1, is a sensory neuron-specific ion channel that serves as polymodal detector of pain-producing chemical and physical stimuli. response VR1 to or noxious heat dynamically potentiated by extracellular protons within pH range encountered during tissue acidosis, such associated with arthritis, infarction, tumor growth, other forms injury. A molecular determinant for this important physiological activity was localized an Glu residue (E600) in the region...
Asthma is an inflammatory disorder caused by airway exposures to allergens and chemical irritants. Studies focusing on immune, smooth muscle, epithelial function revealed many aspects of the disease mechanism asthma. However, limited efficacies immune-directed therapies suggest involvement additional mechanisms in asthmatic inflammation. TRPA1 irritant-sensing ion channel expressed chemosensory nerves. TRPA1-activating stimuli such as cigarette smoke, chlorine, aldehydes, scents are among...
Sensory neurons in the airways are finely tuned to respond reactive chemicals threatening airway function and integrity. Nasal trigeminal nerve endings particularly sensitive oxidants formed polluted air during oxidative stress as well chlorine, which is frequently released industrial domestic accidents. Oxidant activation of induces respiratory depression, nasal obstruction, sneezing, cough, pain. While normally protective, chemosensory reflexes can provoke severe complications patients...
Poison ivy-induced allergic contact dermatitis (ACD) is the most common environmental condition in United States. Case numbers of poison ivy ACD are increasing due to growing biomass and geographical expansion content allergen, urushiol, likely attributable rising atmospheric CO2 Severe treatment-resistant itch major complaint affected patients. However, because limited clinical data poorly characterized models, pruritic mechanisms remain unknown. Here, we aim identify a mouse model by...
Menthol, the cooling natural product of peppermint, is widely used in medicinal preparations for relief acute and inflammatory pain sports injuries, arthritis, other painful conditions. Menthol induces sensation by activating TRPM8, an ion channel cold-sensitive peripheral sensory neurons. Recent studies identified additional targets menthol, including irritant receptor, TRPA1, voltage-gated channels neurotransmitter receptors. It remains unclear which these contribute to menthol-induced...
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. provides concise overviews, mostly tabular format, key properties approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There an emphasis on selective pharmacology (where available), plus links open access knowledgebase source targets their ligands (https://www.guidetopharmacology.org/), which more detailed views target ligand properties. Although constitutes almost...
E-cigarette or vaping product use-associated lung injury (EVALI) is a severe pulmonary illness associated with the use of e-cigarettes products that was officially identified and named in 2019. This American Thoracic Society workshop convened 2021 to identify prioritize research regulatory needs adequately respond EVALI outbreak prevent similar instances disease e-cigarette use. An interdisciplinary group 26 experts adult pediatric clinical care, public health, oversight, toxicology were for...
The treatment of acute lung injury caused by exposure to reactive chemicals remains challenging because the lack mechanism-based therapeutic approaches. Recent studies have shown that transient receptor potential vanilloid 4 (TRPV4), an ion channel expressed in pulmonary tissues, is a crucial mediator pressure-induced damage associated with ventilator-induced injury, heart failure, and infarction. Here, we examined effects two novel TRPV4 inhibitors mice exposed hydrochloric acid, mimicking...
Menthol, the cooling agent in peppermint, is added to almost all commercially available cigarettes. Menthol stimulates olfactory sensations, and interacts with transient receptor potential melastatin 8 (TRPM8) ion channels cold-sensitive sensory neurons, ankyrin 1 (TRPA1), an irritant-sensing channel. It highly controversial whether menthol cigarette smoke exerts pharmacological actions affecting smoking behavior. Using plethysmography, we investigated effects of on respiratory irritation...
The release of methyl isocyanate in Bhopal, India, caused the worst industrial accident history. Exposures to isocyanates induce lacrimation, pain, airway irritation, and edema. Similar responses are elicited by chemicals used as tear gases. Despite frequent exposures, biological targets gases vivo have not been identified, precluding development effective countermeasures. We use Ca(2+) imaging electrophysiology show that noxious effects those all major gas agents activation influx membrane...
Background and Purpose Eucalyptol (1,8‐cineol), the major ingredient in essential oil of eucalyptus leaves other medicinal plants, has long been known for its anti‐inflammatory properties. interacts with TRP cation channels among targets, but it is unclear which these mediates effects. Experimental Approach Effects eucalyptol were compared wild‐type TRPM8 channel‐deficient mice two different models: footpad inflammation elicited by complete Freund's adjuvant (CFA) pulmonary following...
The introduction of a new product line the popular disposable electronic cigarette brand Puffbar, advertised as containing synthetic nicotine, has drawn attention to increasing use nicotine in marketed products and its uncertain regulatory status. A search Truth Tobacco Industry Documents revealed that industry considered using already 1960s, efforts were abandoned due high costs insufficient purity. Recent patents renewed develop more efficient strategies for synthesis nicotine. Nicotine...
Abstract Introduction Menthol, through its cooling and pleasant sensory effects, facilitates smoking tobacco product initiation, resulting in the high popularity of mint/menthol-flavored E-cigarettes. More recently, E-cigarette vendors started marketing synthetic agents as additives that impart a effect but lack characteristic minty odor. Knowledge about content coolants US-marketed products associated health risks is limited. Aims Methods E-liquid vendor sites were searched with terms...