A5078637773- Ion channel regulation and function
- Neuroscience and Neural Engineering
- Nicotinic Acetylcholine Receptors Study
- Advanced Fluorescence Microscopy Techniques
- Mitochondrial Function and Pathology
- Graphene and Nanomaterials Applications
- Neural dynamics and brain function
- Chemical Reactions and Isotopes
- Pharmacological Receptor Mechanisms and Effects
- ATP Synthase and ATPases Research
- Carbon and Quantum Dots Applications
- Graphene research and applications
- Receptor Mechanisms and Signaling
- Monoclonal and Polyclonal Antibodies Research
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Nanopore and Nanochannel Transport Studies
- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
Northeastern University
2020-2023
Universidad del Noreste
2021-2023
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. provides concise overviews, mostly tabular format, key properties nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links open access knowledgebase source and their ligands (www.guidetopharmacology.org), which more detailed views target ligand properties. Although constitutes over 500 pages, material presented substantially reduced compared...
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. provides concise overviews, mostly tabular format, key properties approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There an emphasis on selective pharmacology (where available), plus links open access knowledgebase source targets their ligands (https://www.guidetopharmacology.org/), which more detailed views target ligand properties. Although constitutes almost...
Abstract Miniaturized fluorescence microscopes (miniscopes) enable imaging of calcium events from a large population neurons in freely behaving animals. Traditionally, miniscopes have only been able to record single wavelength. Here, we present new open-source dual-channel Miniscope that simultaneously records two wavelengths To simultaneous acquisition fluorescent wavelengths, incorporated CMOS sensors into Miniscope. validate our Miniscope, imaged hippocampal CA1 region co-expressed...
Graphene quantum dots (GQDs) are emerging as a versatile nanomaterial with numerous proposed biomedical applications. Despite the explosion in potential applications, molecular interactions between GQDs and complex biomolecular systems, including potassium-ion (K
Cardiovascular diseases remain the leading cause of death worldwide. Most deaths are sudden and occur secondary to occlusion coronary arteries resulting in a rapid decrease cellular oxygen levels. Acute hypoxia is proarrhythmic, disordered electrical signals, conduction block, uncoordinated beating myocardium. Although acute recognized perturb electrophysiology heart muscle, mechanistic basis for effect has remained elusive, hampering development targeted therapeutic interventions. Here, we...
The 4TM family of K channels mediate many the background potassium currents observed in native cells. They are open across physiological voltage-range and regulated by a wide array neurotransmitters biochemical mediators. pore-forming α-subunit contains two pore loop (P) domains subunits assemble to form one ion conduction pathway lined four P domains. It is important note that single do not have pores but each subunit has its primary sequence; hence name two-pore domain, or K2P (and...
Prior adversity increases susceptibility to subsequent stressful events, but the causal underlying changes in brain circuitry are poorly understood. We harnessed unbiased whole-brain activity mapping identify circuits that functionally remodeled by prior adversity. This revealed anterior hypothalamic nucleus (AHN) displays heightened stress reactivity previously stressed mice. was accompanied increased functional connectivity between AHN and a threat-related limbic network. Using vivo...
The 4TM family of K channels mediate many the background potassium currents observed in native cells. They are open across physiological voltage-range and regulated by a wide array neurotransmitters biochemical mediators. pore-forming α-subunit contains two pore loop (P) domains subunits assemble to form one ion conduction pathway lined four P domains. It is important note that single do not have pores but each subunit has its primary sequence; hence name domain, or K2P (and two-pore...
The 4TM family of K channels mediate many the background potassium currents observed in native cells. They are open across physiological voltage-range and regulated by a wide array neurotransmitters biochemical mediators. pore-forming α-subunit contains two pore loop (P) domains subunits assemble to form one ion conduction pathway lined four P domains. It is important note that single do not have pores but each subunit has its primary sequence; hence name two-pore domain, or K2P (and...