A5009467053- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Neural dynamics and brain function
- Epilepsy research and treatment
- Alzheimer's disease research and treatments
- Zebrafish Biomedical Research Applications
- Neuroendocrine regulation and behavior
- Photoreceptor and optogenetics research
- EEG and Brain-Computer Interfaces
- Advanced Fluorescence Microscopy Techniques
- Neuroscience and Neural Engineering
- Nicotinic Acetylcholine Receptors Study
- Neurological disorders and treatments
Icahn School of Medicine at Mount Sinai
2023-2025
Allen Institute for Brain Science
2025
ABSTRACT Alzheimer’s disease (AD) is a chronic neurodegenerative disorder that characterized by memory loss and progressive cognitive impairments. In mouse models of AD pathology, studies have found neuronal synaptic deficits in the hippocampus, but less known about what happens medial entorhinal cortex (MEC), which primary spatial input to hippocampus an early site pathology. Here, we measured intrinsic excitability activity MEC layer II (MECII) stellate cells, MECII pyramidal III (MECIII)...
Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by memory loss and progressive cognitive impairments. In mouse models of AD pathology, studies have found neuronal synaptic deficits in hippocampus, but less known about changes medial entorhinal cortex (MEC), which the primary spatial input to hippocampus an early site pathology. Here, we measured intrinsic excitability activity MEC layer II (MECII) stellate cells, MECII pyramidal III (MECIII) excitatory neurons...
Abstract Miniaturized fluorescence microscopes (miniscopes) enable imaging of calcium events from a large population neurons in freely behaving animals. Traditionally, miniscopes have only been able to record single wavelength. Here, we present new open-source dual-channel Miniscope that simultaneously records two wavelengths To simultaneous acquisition fluorescent wavelengths, incorporated CMOS sensors into Miniscope. validate our Miniscope, imaged hippocampal CA1 region co-expressed...
Alzheimer's disease (AD) is a neurodegenerative characterized by progressive impairments in episodic and spatial memory, as well circuit network-level dysfunction. While functional medial entorhinal cortex (MEC) hippocampus (HPC) have been observed patients rodent models of AD, it remains unclear how communication between these regions breaks down disease, what specific physiological changes are associated with the onset memory impairment. We used silicon probes to simultaneously record...
The precise timing of neuronal spiking relative to the brain's endogenous oscillations (i.e., phase-locking or spike-phase coupling) has long been hypothesized coordinate cognitive processes and maintain excitatory-inhibitory homeostasis. Indeed, disruptions in theta have described models neurological diseases with associated deficits seizures, such as Alzheimer's disease, temporal lobe epilepsy, autism spectrum disorders. However, due technical limitations, determining if causally...
Temporal lobe epilepsy (TLE) causes pervasive and progressive memory impairments, yet the specific circuit changes that drive these deficits remain unclear. To investigate how hippocampal-entorhinal dysfunction contributes to in epilepsy, we performed simultaneous
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ABSTRACT A core necessity to behavioral neuroscience research is the ability accurately measure performance on assays, such as novel object location and recognition tasks. These tasks are widely used in a rodent’s instinct for investigating features proxy test their memory of previous experience. Automated tools scoring videos can be cost prohibitive often have difficulty distinguishing between active investigation an simply being close proximity object. As such, many experimenters continue...