A5070707950- Cancer-related gene regulation
- RNA modifications and cancer
- RNA regulation and disease
- Esophageal Cancer Research and Treatment
- Peptidase Inhibition and Analysis
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Mechanisms of cancer metastasis
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Digestive system and related health
- Colorectal Cancer Treatments and Studies
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Cancer, Lipids, and Metabolism
- Cancer Cells and Metastasis
- Tissue Engineering and Regenerative Medicine
- Bladder and Urothelial Cancer Treatments
- TGF-β signaling in diseases
- Urinary and Genital Oncology Studies
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Cancer Research and Treatments
- Cancer Genomics and Diagnostics
First Affiliated Hospital of Zhengzhou University
2016-2025
Zhejiang Chinese Medical University
2024
Weatherford College
2022
Zhengzhou University
2010-2021
First Affiliated Hospital Zhejiang University
2021
University of Hong Kong
2010-2013
Sun Yat-sen University
2010-2013
Sun Yat-sen University Cancer Center
2010-2013
First Affiliated Hospital of Guangzhou Medical University
2013
Guangzhou Medical University
2013
Abstract Despite success in hematologic malignancies, the treatment landscape of chimeric antigen receptor (CAR) T cell therapy for solid tumors remains limited. Claudin18.2 (CLDN18.2)-redirected CAR cells showed promising efficacy against gastric cancer (GC) a preclinical study. Here we report interim analysis results an ongoing, open-label, single-arm, phase 1 clinical trial CLDN18.2-targeted (CT041) patients with previously treated, CLDN18.2-positive digestive system cancers ( NCT03874897...
<h3>Background</h3> To understand the involvement of micro-RNA (miRNA) in development and progression oesophageal squamous cell carcinoma (ESCC), miRNA profiles were compared between tumour corresponding non-tumour tissues. <h3>Methods</h3> miRCURY LNA array was used to generate expressing profile. Real-time quantitative PCR applied detectthe expression <i>miR-375</i> ESCC samples its correlation with insulin-like growth factor 1 receptor (IGF1R). Methylation-specific study methylation...
Importance Gastric and gastroesophageal junction cancers are diagnosed in more than 1 million people worldwide annually, few effective treatments available. Sintilimab, a recombinant human IgG4 monoclonal antibody that binds to programmed cell death (PD-1), combination with chemotherapy, has demonstrated promising efficacy. Objective To compare overall survival of patients unresectable locally advanced or metastatic gastric who were treated sintilimab chemotherapy vs placebo chemotherapy....
Lymph node metastasis, the leading cause of mortality in esophageal squamous carcinoma (ESCC) with a highly complex tumor microenvironment, remains underexplored. Here, transcriptomes 85 263 single cells are analyzed from four ESCC patients lymph metastases. Strikingly, it is observed that metastatic microenvironment undergoes emergence or expansion interferon induced IFIT3+ T, B cells, and immunosuppressive such as APOC1+ APOE+ macrophages myofibroblasts expression immunoglobulin genes...
Abstract Esophageal squamous cell carcinoma (ESCC), the major histologic form of esophageal cancer, is a heterogeneous tumor displaying complex variety genetic and epigenetic changes. Aberrant RNA editing adenosine-to-inosine (A-to-I), as it catalyzed by adenosine deaminases acting on (ADAR), represents common posttranscriptional modification in certain human diseases. In this study, we investigated status role ADARs altered A-to-I ESCC tumorigenesis. Among three ADAR enzymes expressed...
Esophageal cancer is one of the most lethal cancers worldwide with poor survival and limited therapeutic options. The discovery microRNAs created a new milestone in research. miR-377 located chromosome region 14q32, which frequently deleted esophageal squamous cell carcinoma (ESCC), but biological functions, clinical significance implication ESCC are largely unknown. In this study, we found that expression was significantly downregulated tumor tissue serum patients ESCC. Both levels were...
Objective: The transcription factor forkhead box protein O1 (FOXO1) is critical for regulating cytokine and chemokine secretion. However, its function in the tumor microenvironment (TME) remains largely unexplored. In this study, we characterized prognostic value of FOXO1 interaction between tumor-derived M2 macrophages esophageal squamous cell carcinoma (ESCC). Methods: expression macrophage infiltration clinical samples mouse models were quantified using quantitative real-time polymerase...
Esophageal squamous cell carcinoma (ESCC), the major histologic subtype of esophageal cancer, is a devastating disease characterized by distinctly high incidences and mortality rates. However, there remains limited understanding molecular events leading to development progression disease, which are paramount importance defining biomarkers for diagnosis, prognosis, personalized treatment. By high-throughout transcriptome sequence profiling nontumor ESCC clinical samples, we identified subset...
// Ye Song 1 , Jiangchao Li 2 Yinghui Zhu Yongdong Dai Tingting Zeng Lulu Liu Jianbiao Hongbo Wang Yanru Qin 3 Musheng Xin-Yuan Guan 1, 4 Yan State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Center, Guangzhou, 510060, Vascular Biology Research Institute, Guangdong Pharmaceutical University, Department Clinical Oncology, the First Affiliated Hospital, Zhengzhou Zhengzhou, The Hong Kong, Correspondence to: Li,...
Abstract The ubiquitous second messenger Ca2+ has long been recognized as a key regulator in cell migration. Locally confined Ca2+, particular, is essential for building front-to-rear gradient, which serves to maintain the morphologic polarity required directionally migrating cells. However, little known about source of and mechanism by they crosstalk between different signaling pathways cancer Here, we report that calcium release–activated modulator 2 (ORAI2), poorly characterized...
This study aims to clarify the underlying mechanism for tumor suppressive function of lnc TUSC7 in chemotherapy resistance esophageal squamous cell carcinoma (ESCC).TUSC7, miR-224 and DESC1 expressions ESCC tissues cells were detected by qRT-PCR. Protein level DESC1, EGFR p-AKT observed Western blot. Overall survival was calculated using Kaplan-Meier method. Dual-luciferase reporter gene assay RIP used comfirm binding miR-224, DESC1. Cell proliferation, apoptosis, colony formation MTT, Flow...
Abstract Background Lymph node metastasis is one of most common determinants the stage and prognosis gastric cancer (GC). However, key molecular events mechanisms mediating lymph remain elusive. Methods RNA sequencing was used to identify driver genes responsible for in four cases primary tumors, metastatic lesions nodes matched normal epithelial tissue. qRT–PCR IHC were applied examine RPRD1B expression. Metastatic functions evaluated vitro vivo. RNA-seq target genes. ChIP, EMSA dual...
Cancer-associated fibroblast assists cancer cell in building rampart to block T infiltration and resist anti–PD-1 drugs.
Significance Familial esophageal squamous cell carcinoma (ESCC) often shows early onset and worse prognosis. Little is known about the genetic basis underlying pathogenesis of familial ESCC. To identify alterations associated with ESCC susceptibility, we compared gene-expression profiles sporadic ESCCs. We found that A-to-I RNA editing–mediated downregulation SLC22A3 almost exclusively present in may serve as a potential biomarker for patients. Molecular mechanism study further revealed...
Oesophageal squamous cell carcinoma (ESCC) is the most common histological subtype of oesophageal cancer. The disease particularly prevalent in southern China. incidence on rise and its overall survival rate remains dismal. Identification characterization better molecular markers for early detection therapeutic targeting are urgently needed. Here, we report levels transmembrane soluble neuropilin-2 (NRP2) to be significantly up-regulated ESCC, correlate positively with advanced tumour stage,...
EGFR exon 20 insertions ( e20ins) account for up to 10% of mutations in lung cancer; however, tumors with e20ins had poor response rates tyrosine kinase inhibitors (TKIs) including gefitinib, erlotinib, afatinib, and osimertinib, the heterogeneity further complicates clinical studies. Here, we retrospectively screened next‐generation sequencing (NGS) data from 24 468 cancer patients, a total 85 unique variants were identified 547 cases (2.24%), p.A767_V769dup (25.1%) p.S768_D770dup (17.6%)...