A5102876126- Neuroblastoma Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Cancer-related Molecular Pathways
- Cell death mechanisms and regulation
- Cancer therapeutics and mechanisms
- Cancer Genomics and Diagnostics
- Ubiquitin and proteasome pathways
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Corrosion Behavior and Inhibition
- Pancreatic and Hepatic Oncology Research
- Cancer Diagnosis and Treatment
- Clinical Reasoning and Diagnostic Skills
- MRI in cancer diagnosis
- Potassium and Related Disorders
- Workplace Health and Well-being
- Cancer-related molecular mechanisms research
- Animal Virus Infections Studies
- ATP Synthase and ATPases Research
- Respiratory viral infections research
- Chemical synthesis and alkaloids
- Sepsis Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Piperaceae Chemical and Biological Studies
Beijing Hospital of Traditional Chinese Medicine
2025
Capital Medical University
2025
Beijing University of Chinese Medicine
2025
Collaborative Innovation Center of Chemical Science and Engineering Tianjin
2024
Tianjin University
2024
State Key Laboratory of Chemical Engineering
2024
Peking University
2024
Chinese Academy of Sciences
2008-2022
Changchun Institute of Applied Chemistry
2022
Ningbo University
2022
Abstract ALK receptor tyrosine kinase has been shown to be a therapeutic target in neuroblastoma. Germline activating mutations are responsible for the majority of hereditary neuroblastoma and somatic also frequently observed sporadic cases advanced NB. Crizotinib, first-line therapy treatment non-small cell lung cancer (NSCLC) harboring rearrangements, demonstrates striking efficacy against ALK-rearranged However, crizotinib fails effectively inhibit activity when present within its domain,...
Hepatoblastoma (HB) is the most common pediatric liver malignancy. High-risk patients have poor survival, and current chemotherapies are associated with significant toxicities. Targeted therapies needed to improve outcomes patient quality of life. Most HB cases TP53 wild-type; therefore, we hypothesized that targeting p53 regulator Murine double minute 4 (MDM4) reactivate signaling may show efficacy. MDM4 expression was elevated in samples, increased strongly correlated decreased target...
Small cell lung cancer (SCLC) accounts for 12 to 16% of neoplasms and has a high rate metastasis. The present study demonstrates the antiproliferative effect retinoic acid amide in vitro vivo against human cells. results from MTT assay showed significant growth inhibition six tested lines clonogenic at 30 μM. Retinoic also leads G2/M-phase cycle arrest apoptosis It caused JAK2, STAT3, STAT5, increased level p21WAF1, decreased cyclin A, B1, Bcl-XL expression. exhibited synergistic on effects...
Purpose To investigate the correlations between minimum and mean apparent diffusion coefficient (ADC) values of hepatocellular carcinoma (HCC) pathological grade. Materials Methods Preoperative magnetic resonance imaging (MRI) images 241 patients with HCC confirmed by pathology were retrospectively analyzed. All underwent preoperative diffusion-weighted (DWI) on a 1.5T MRI scanner. The ADC tumors measured. compared in different grades grade Receiver operating characteristic (ROC) curves...
A bioassay-guided phytochemical study of the fruits Cornus officinalis led to isolation six new iridoid glycoside dimers, named corndiridoside A-F (1-6), along with 11 analogs (7-17). The structure these dimers was elucidated using HRESIMS, 1D and 2D NMR, IR, UV spectra, as well literature comparisons. anti-inflammatory activity all compounds evaluated, revealing a significant inhibitory effect on production NO in LPS-stimulated RAW 264.7 cells at concentrations 25 50 μM. Of six, 2 3 showed...
Abstract Neuroblastoma (NB) is the most common extracranial tumor in children. Unlike adult tumors, suppressor protein 53 (p53) mutations occur with a relatively low frequency NB and downstream function of p53 intact cell lines. Wip1 negative regulator hindrance activity by novel inhibitor GSK2830371 potential strategy to activate p53’s suppressing NB. Yet, vivo efficacy possible mechanisms have not yet been elucidated. Here we report that induced Chk2/p53-mediated apoptosis cells...
Abstract Dual specificity protein phosphatase 26 (DUSP26) is overexpressed in high-risk neuroblastoma (NB) and contributes to chemoresistance by inhibiting p53 function. In vitro , DUSP26 has also been shown effectively inhibit p38 MAP kinase. We hypothesize that will result decreased NB cell growth a and/or p38-mediated manner. NSC-87877 (8-hydroxy-7-[(6-sulfo-2-naphthyl)azo]-5-quinolinesulfonic acid), novel small molecule inhibitor, shows effective inhibition induction of apoptosis lines....
Currently, preclinical testing of therapies for hepatoblastoma (HB) is limited to subcutaneous and intrasplenic xenograft models that do not recapitulate the hepatic tumors seen in patients. We hypothesized injection HB cell lines into livers mice would result liver resemble their clinical counterparts. HepG2 Huh-6 were injected, tumor growth was monitored with bioluminescence imaging (BLI) magnetic resonance (MRI). Levels human α-fetoprotein (AFP) serum animals. Immunohistochemical gene...
Hepatoblastoma is the most common malignant liver tumor in children. Since it often unresectable and exhibits drug resistance, treatment of advanced hepatoblastoma challenging. The orphan nuclear receptor homolog‑1 (LRH‑1) serves prominent roles malignancy; however, to best our knowledge, role LRH‑1 remains unknown. In present study, human cell lines were analyzed; mRNA protein expression levels significantly higher HepG2 HuH6 cells compared with those HepT1 control THLE‑2 cells. Knockdown...
// Zhenghu Chen 1, 2 , Yanling Zhao Yang Yu Jonathan C. Pang 2, 3 Sarah E. Woodfield 4 Ling Tao Shan Guan Huiyuan Zhang Shayahati Bieerkehazhi 5, 6 Yan Shi Roma Patel Sanjeev A.Vasudevan Joanna S. Yi Jodi A. Muscal Guo-Tong Xu 1 and Jianhua Department of Ophthalmology, Shanghai Tenth People's Hospital, Tongji University School Medicine, 200072, P. R. China Texas Children's Cancer Center, Pediatrics, Dan L. Duncan Baylor College Houston, 77030, USA Biosciences, Weiss Natural Sciences, Rice...
BACKGROUND Blunt aortic injury (BAI) in young patients with a compliant aorta and evolving hyperdynamic physiology may result significant variation diameter during the cardiac cycle. Intravascular ultrasound (IVUS) be useful to detect real-time variations diameters for more reliable sizing undergoing thoracic endovascular repair (TEVAR) of BAI. METHODS This is single-institution retrospective study who underwent TEVAR BAI Level 1 trauma center from January 2004 2014. Patients either survey...
Abstract RING finger protein 8 (RNF8) is an E3 ligase that pivotal for DNA repair. However, the role of RNF8 in ulcerative colitis (UC) remains unclear. The aim this study to investigate effect and mechanism on UC model induced by trinitrobenzene sulfonic acid (TNBS) mice. Lentiviruses overexpressing were injected into mice after induction UC. histopathological changes colon tissues assessed haematoxylin eosin staining. mRNA level was detected real-time quantitative polymerase chain...
Abstract Background Severe sepsis can cause significant morbidity and mortality in pediatric patients. Early recognition treatment are vital to improving patient outcomes. Objective The study aimed evaluate the impact of a best practice alert timely improve acute care setting. Methods A multidisciplinary team adapted from emergency room setting facilitate identification inpatient areas. included clinical decision support aid treatment, prompting use intravenous fluid boluses, antibiotic...
Cells can regulate a variety of behaviors by sensing mechanical signals, including growth, differentiation, apoptosis and so on. Yes-associated protein (YAP) is mechanically sensitive that be used as an indicator mechanosignaling transduction. Unlike macroscopic statistical analysis, single-cell analysis more demanding challenging in terms mechanistic regulation. Here, we quantified the location, amplitude duration stimulation precise modulation, simultaneously observed force induced YAP...