A5101480321- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Lung Cancer Treatments and Mutations
- Calcium signaling and nucleotide metabolism
- Alzheimer's disease research and treatments
- Lung Cancer Research Studies
- Brain Metastases and Treatment
- Autophagy in Disease and Therapy
- Reconstructive Surgery and Microvascular Techniques
- Cellular transport and secretion
- Ubiquitin and proteasome pathways
- HIV Research and Treatment
- Ear and Head Tumors
- Cancer Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Cancer, Stress, Anesthesia, and Immune Response
- Mosquito-borne diseases and control
- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Bone fractures and treatments
- Diet and metabolism studies
- Peptidase Inhibition and Analysis
- Mitochondrial Function and Pathology
- Nanoplatforms for cancer theranostics
Kunming University of Science and Technology
2023-2025
Xi'an Honghui Hospital
2016-2025
Xi'an Jiaotong University
2016-2025
Sichuan Agricultural University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2001-2024
Harbin Medical University
2014-2024
Third Affiliated Hospital of Harbin Medical University
2014-2024
Jiangsu Province Hospital
2016-2024
First Affiliated Hospital of Harbin Medical University
2024
Guangxi Medical University
2024
Abstract We identified cellular targets of canonical Wnt signaling within the skeleton, which included chondrocytes, osteoblasts, and osteocytes in growing bone, but only chondrocytes mature skeleton. Mechanical deformation induced osteoblasts vitro. Introduction: Genetic evidence mice humans has implicated pathway control skeletal development bone mass. However, little is known details skeleton vivo. used indicator TOPGAL to identify cells activated this during Materials Methods: examined...
The blood-brain barrier (BBB) is important physiologically. Pathologically, BBB disruption has been implicated in a wide spectrum of neurological disorders including Parkinson's disease (PD). Recent studies indicate that caffeine protective against PD, but by poorly understood mechanisms. Using MPTP neurotoxin model PD we tested the hypothesis actions were because of, at least part, preventing MPTP-induced dysfunction. FVB mice pre-treated with (10 mg/kg, i.p.) or saline for 7 days prior to...
Abstract High levels of serum cholesterol and disruptions the blood brain barrier (BBB) have all been implicated as underlying mechanisms in pathogenesis Alzheimer's disease. Results from studies conducted animals humans suggest that caffeine might be protective against disease but by poorly understood mechanisms. Using rabbits fed a cholesterol-enriched diet, we tested our hypothesis chronic ingestion protects high diet-induced BBB. New Zealand were 2% 3 mg was administered daily drinking...
Abstract Objective Chondrocytes of the epiphyseal growth zone are regulated by Indian hedgehog (IHH)–parathyroid hormone–related protein (PTHrP) axis. In weight‐bearing joints, this comes to be subdivided secondary ossification center into distinct articular and cartilage structures. The purpose study was explore cells origin, localization, regulation expression, putative functions IHH PTHrP in mouse. Methods We assessed expression an allelic PTHrP‐LacZ–knockin mouse several versions...
Combined anti-retroviral therapeutic drugs effectively increase the lifespan of HIV-1-infected individuals who then have a higher prevalence HAND (HIV-1 associated neurocognitive disorder). Soluble factors including HIV-1 proteins released from cells been implicated in pathogenesis HAND, and particular attention has paid to Tat (transactivator transcription) protein because its ability directly excite neurons cause neuronal cell death. Since enters by receptor-mediated endocytosis since...
MicroRNAs (miRNAs) have been identified as important post-transcriptional regulators involved in various biological and pathological processes of cells, but their underlying mechanisms chemosensitivity metastasis not fully elucidated. The objective this study was to identify miR-181b its mechanism the NSCLC. We found that expression levels were lower A549/DDP cells compared with A549 cells. Functional assays showed overexpression inhibited proliferation, enhanced DDP, attenuated migration...
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is an enveloped, single-stranded RNA virus. Humans infected with SARS-CoV-2 develop a disease known as coronavirus 2019 (COVID-19) symptoms and consequences including distress (ARDS), cardiovascular disorders, death. appears to infect cells by first binding viral spike proteins host protein angiotensin-converting enzyme 2 (ACE2) receptors; the virus endocytosed following priming transmembrane protease serine (TMPRSS2). The process...
The PTHrP gene generates low-abundance mRNA and protein products that are not easily localized by in situ hybridization histochemistry or immunohistochemistry. We report here a PTHrP-lacZ knockin mouse which β-gal activity seems to provide simple sensitive read-out of expression. Introduction: PTH-related (PTHrP) is widely expressed fetal adult tissues, typically as maybe difficult localize conventional methods. created means surveying expression general identifying previously unrecognized...
Abstract Angiotensin II (Ang II) is a bioactive peptide of the renin–angiotensin system, acting not only as vasoconstrictor but also growth promoter via angiotensin type 1 receptor (AT1R) in some cancer. In this study, we examined mechanisms by which Ang affected cell proliferation AT1R‐positive MCF‐7 human breast cancer cells. stimulated cells dose‐ and time‐dependent manner. The maximal effect on was obtained with 10 −4 M at 24 h. Losartan (10 −5 M, an AT1R antagonist) significantly...
// Ying Xing 1 , Qingwei Meng Xuesong Chen Yanbin Zhao Wei Liu Jing Hu Feng Xue Xiaoyuan Wang Li Cai The Fourth Department of Medical Oncology, Harbin University Cancer Hospital, Harbin, China Correspondence to: Cai, e-mail: caili@ems.hrbmu.edu.cn Keywords: TRIM44, non-small cell lung cancer, metastasis, epithelial-mesenchymal transition, mTOR signaling pathway Received: September 26, 2015 Accepted: March 04, 2016 Published: April 05, ABSTRACT Tripartite motif-containing protein 44 (TRIM44)...
// Xiaoqun Dong 1,2 , Qiushi Lin Arihiro Aihara 3 Yu Li 1 Chiung-Kuei Huang Waihong Chung Qi Tang Xuesong Chen Rolf Carlson Christina Nadolny Gregory Gabriel 4 Mark Olsen 5 and Jack R. Wands Department of Biomedical Pharmaceutical Sciences, College Pharmacy, The University Rhode Island, Kingston, RI, USA 2 Current address: Internal Medicine, Oklahoma Health Sciences Center, City, OK, Liver Research Island Hospital, Warren Alpert Medical School, Brown University, Providence, Chemistry...
Idiopathic pulmonary fibrosis (IPF) pathogenesis involves multiple pathways, and combined antifibrotic therapy is needed for future IPF therapy. Inhaled interferon-γ (IFN-γ) was recently shown to be safe without systemic effects in patients with IPF.To examine the vitro of individual treatment IFN-γ pirfenidone (PFD) on normal fibroblast activation extracellular matrix remodeling after TGF-β1 PDGF-BB stimulation.IPF human lung fibroblasts (NHLF) were treated IFN-γ, PFD or a combination both...
Signaling pathways critical for embryonic development re-emerge in adult pancreas during tumorigenesis. Aspartate β-hydroxylase (ASPH) drives cell motility/invasion pancreatic development/differentiation. We explored if dysregulated ASPH is critically involved cancer pathogenesis. To demonstrate if/how mediates malignant phenotypes, proliferation, migration, 2-D/3-D invasion, pancreatosphere formation, immunofluorescence, Western blot, co-immunoprecipitation, invadopodia...
Cyclophosphamide (CTX) is a commonly used chemotherapeutic agent for breast cancer. However, chemoresistance remains common clinical problem. Osteopontin (OPN) has been shown to induce by inhibiting apoptosis; p38 MAPK pathway reported be involved in chemotherapy-induced apoptosis. Thus, this study investigated whether OPN knockdown would chemosensitize MDA-MB-231 cells CTX enhancing apoptosis through activating pathway. were transfected with stable siRNA plasmid, and it was found that...