A5100612714- Atherosclerosis and Cardiovascular Diseases
- Angiogenesis and VEGF in Cancer
- Cardiac Fibrosis and Remodeling
- MicroRNA in disease regulation
- Antiplatelet Therapy and Cardiovascular Diseases
- S100 Proteins and Annexins
- Cell Adhesion Molecules Research
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Adipose Tissue and Metabolism
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Congenital heart defects research
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Cell death mechanisms and regulation
- Pancreatic function and diabetes
- Protease and Inhibitor Mechanisms
- Chemokine receptors and signaling
- Cancer-related Molecular Pathways
- Pluripotent Stem Cells Research
- Tissue Engineering and Regenerative Medicine
- Circular RNAs in diseases
- Inflammasome and immune disorders
- Acute Myocardial Infarction Research
- Ubiquitin and proteasome pathways
Xinxiang University
2024-2025
Shaanxi University of Science and Technology
2025
Shinshu University
2025
General Hospital of Shenyang Military Region
2014-2024
Army Medical University
2024
Command Hospital
2021-2024
Cardiovascular Institute Hospital
2009-2024
Hunan University of Traditional Chinese Medicine
2024
University of Wisconsin–Madison
2023
Peking University Shenzhen Hospital
2008-2023
Background:The continued success of oncological therapeutics is dependent on the mitigation treatment-related adverse events, particularly cardiovascular toxicities.As such, there an important need to understand basic mechanisms drug toxicities in process antitumor therapy.Our aim this study was elucidate underlying sorafenib (sor)-induced cardiomyocyte damage.Methods: Primary mouse cardiomyocytes were prepared and treated with sor various other treatments.Cardiomyocyte necroptosis detected...
Atherosclerosis (AS) is the principal pathological cause of atherosclerotic cardiovascular diseases. Chronic endoplasmic reticulum stress (ERS) has been implicated in AS aetiopathogenesis, but underlying molecular interactions remain unclear. This study aims to identify mechanisms ERS pathogenesis inform innovative diagnostic approaches and therapeutic targets for managing AS. GSE28829 GSE43292—human early advanced carotid tissue samples—were obtained from Gene Expression Omnibus database....
BACKGROUND: The decrease in S-nitrosoglutathione reductase (GSNOR) leads to an elevation of S-nitrosylation, thereby exacerbating the progression cardiomyopathy response hemodynamic stress. However, mechanisms under GSNOR remain unclear. Here, we identify NEDD4 (neuronal precursor cell expressed developmentally downregulated 4) as a novel molecule that plays crucial role pathogenesis pressure overload–induced cardiac hypertrophy, by modulating levels, demonstrating significant therapeutic...
Hyperhomocysteinemia (HHcy) is associated with increased diabetic cardiovascular diseases. However, the role of HHcy in atherogenesis hyperglycemia (HG) remains unknown. To examine and mechanisms by which accelerates HG-induced atherosclerosis, we established an atherosclerosis-susceptible HG mouse model. was mice deficient cystathionine β-synthase (Cbs) homocysteine (Hcy) level could be lowered inducing transgenic human CBS (Tg-hCBS) using Zn supplementation. induced streptozotocin...
Exosomes are important for intercellular communication, but the role of exosomes in communication between adipose tissue (AT) and liver remains unknown. The aim this study is to determine contribution AT-derived nonalcoholic fatty disease (NAFLD). Exosome components, fat content, function were monitored AT mice fed a high-fat diet (HFD) or treated with metformin GW4869 AMPKα1-floxed (Prkaα1fl/fl/wild-type [WT]), Prkaα1−/−, tissue-specific AT-specific Prkaα1−/− modification. In cultured...
Abstract Autophagy plays an important role in the development of diabetic cardiomyopathy. Cellular repressor E1A-stimulated genes 1 (CREG1) is myocardial protective factor. The aim this study was to investigate effects and mechanisms CREG1 Male C57BL/6 J mice, Creg1 transgenic mice cardiac-specific knockout were used establish a type 2 diabetes model. Small animal ultrasound, Masson’s staining western blotting evaluate cardiac function, fibrosis autophagy. Neonatal mouse cardiomyocytes...
Abstract Pathological cardiac hypertrophy is a process of abnormal remodeling cardiomyocytes in response to pressure overload or other stress stimuli, resulting myocardial injury, which major risk factor for heart failure, leading increased morbidity and mortality. General control nonrepressed protein 5 (GCN5)/lysine acetyltransferase 2 A, member the histone lysine families, regulates variety physiological pathological events. However, function GCN5 remains unclear. This study aimed explore...
Abstract Background CREG1 (cellular repressor of E1A‐stimulated genes 1) is a protein involved in cellular differentiation and homeostasis regulation. However, its role skeletal muscle satellite cells regeneration poorly understood. This study aimed to investigate the myogenesis regeneration. Methods RNA sequencing data (GSE8479) was analysed from Gene Expression Omnibus database (GEO, https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi ). We generated Creg1 knockdown specific overexpression mice...
Doxorubicin (DOX)-induced cardiotoxicity limits the application of DOX in cancer patients. Currently, there is no effective prevention or treatment for DOX-induced cardiotoxicity. The cellular repressor E1A-stimulated genes (CREG1) a cardioprotective factor that plays an important role maintenance cardiomyocytes differentiation and homeostasis. However, mechanism CREG1 has not yet been elucidated.
Ethnopharmacological relevance: Fuzheng Jiedu Powder (FZJP) is a famous Chinese medicine prescription included in the 2020 edition of Veterinary Pharmacopoeia. It has function repairing immune cells, inducing interferon production and regulating body. Although previous studies have shown that FZJP can improve function, specific mechanism action unclear.Aim study: The aim this study was to investigate regulatory effects on macrophages its immunomodulatory cyclophosphamide-immunosuppressed...
Neutrophil extracellular traps (NETs) play a critical role in acute myocardial infarction (AMI) and the externalization of S100 family members. Here, we show effects S100A12 on NETs formation injury following AMI. expression increases rapidly neutrophils peaks day 1 after AMI, promoting production exacerbating injury. DNase I, an inhibitor NETs, reduces apoptosis cardiomyocytes induced by S100A12. Mechanistically, interaction Annexin A5 (ANXA5) enhances calcium influx promotes formation....
Although most cancer deaths are caused by metastasis, there no effective therapeutic approaches. This study describes the efficacy of a short synthetic mRNA (s-mRNA) designed sequence non-vesicular extracellular IL1β-mRNA found in pre-metastatic lung tumor-bearing mice. The administration s-mRNA inhibits murine metastasis inducing innate and adaptive immune systems. binds to ZC3H12D, an RNA-binding protein on natural killer cells cytotoxic T lymphocytes. ZC3H12D-s-mRNA complex translocated...
ABSTRACT Myocardial infarction (MI) is a major health threat, with high incidence and poor prognosis. This study aims to discover novel biomarkers therapeutic targets reduce myocardial damage improve patient survival. A comprehensive bioinformatics analysis of MI datasets was conducted identify pivotal genes related pyroptosis autophagy. These underwent protein–protein interaction (PPI) analysis, functional enrichment immune infiltration analysis. Receiver operating characteristic (ROC)...
The serum thyroxine-binding protein, transthyretin (TTR), is made by hepatocytes and choroid plexus epithelium in adults yolk sac cells embryogenesis. Four hepatocyte nuclear factors (HNF-1, -3, -4 C/EBP) that are present liver but not most other adult tissues bind DNA sites the TTR gene sufficient to direct transgenic expression. Three of these proteins were also found cells, which express transgene. A limited construct active a TTR-producing tumor lacks three liver-enriched DNA-binding...
Our aim was to identify the role of homeostatic chemokines CCL19 and CCL21 their common receptor CCR7 in atherogenesis study relationships between CCL19, CCL21, gene variants coronary artery disease a Chinese Han population.Immunohistochemical analysis samples with atherosclerosis various stages showed increased expression atherosclerotic plaques compared nonatherosclerotic controls. Expression levels positive correlation lesion stage. Cell adhesion assays confirmed that promoted monocyte...