A5101898593- Ion Transport and Channel Regulation
- Ion channel regulation and function
- Nitric Oxide and Endothelin Effects
- Renin-Angiotensin System Studies
- Sulfur Compounds in Biology
- Ion Channels and Receptors
- Hormonal Regulation and Hypertension
- Sodium Intake and Health
- Hedgehog Signaling Pathway Studies
- Cardiac Fibrosis and Remodeling
- Signaling Pathways in Disease
- Electrolyte and hormonal disorders
- Genetic and Kidney Cyst Diseases
- Renal and related cancers
- Pluripotent Stem Cells Research
- Drug Transport and Resistance Mechanisms
- Cardiac electrophysiology and arrhythmias
- Heme Oxygenase-1 and Carbon Monoxide
- Advanced Chemical Sensor Technologies
- Neurogenesis and neuroplasticity mechanisms
- Autophagy in Disease and Therapy
- Ubiquitin and proteasome pathways
- Angiogenesis and VEGF in Cancer
- Hydrogen's biological and therapeutic effects
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Harbin Medical University
2016-2025
First Affiliated Hospital of Harbin Medical University
2016-2025
Heilongjiang Academy of Sciences
2016-2025
Ministry of Education of the People's Republic of China
2023-2025
Third Affiliated Hospital of Harbin Medical University
2016-2024
Zhuhai People's Hospital
2022-2023
Jinan University
2013-2023
Hebei University of Engineering
2023
Jilin University
2017
Second Affiliated Hospital of Harbin Medical University
2012-2015
Hydrogen sulfide (H2S) has been shown to have powerful antioxidative and anti-inflammatory properties that can regulate multiple cardiovascular functions. However, its precise role in diabetes-accelerated atherosclerosis remains unclear. We report here H2S reduced aortic atherosclerotic plaque formation with reduction superoxide (O2 (-)) generation the adhesion molecules streptozotocin (STZ)-induced LDLr(-/-) mice but not LDLr(-/-)Nrf2(-/-) mice. In vitro, inhibited foam cell formation,...
Aortic aneurysm and aortic dissection (AAD) are life-threatening vascular diseases, with endothelium being the primary target for AAD treatment. Protein S-sulfhydration is a newly discovered posttranslational modification whose role in has not yet been defined. This study aims to investigate whether protein regulates its underlying mechanism.Protein endothelial cells (ECs) during was detected hub genes regulating homeostasis of were identified. Clinical data patients healthy controls...
BACKGROUND: The decrease in S-nitrosoglutathione reductase (GSNOR) leads to an elevation of S-nitrosylation, thereby exacerbating the progression cardiomyopathy response hemodynamic stress. However, mechanisms under GSNOR remain unclear. Here, we identify NEDD4 (neuronal precursor cell expressed developmentally downregulated 4) as a novel molecule that plays crucial role pathogenesis pressure overload–induced cardiac hypertrophy, by modulating levels, demonstrating significant therapeutic...
Sodium reabsorption through the epithelial sodium channel (ENaC) at distal segment of kidney plays an important role in salt-sensitive hypertension. We reported previously that hydrogen peroxide (H2O2) stimulates ENaC A6 nephron cells via elevation phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) apical membrane. Here we report H2S can antagonize H2O2-induced activation cells. Our cell-attached patch-clamp data show open probability (PO ) was significantly increased by exogenous H2O2,...
S-Nitrosylation (SNO), a prototypic redox-based posttranslational modification, is involved in cardiovascular disease. Aortic aneurysm and dissection are high-risk diseases without an effective cure. The aim of this study was to determine the role SNO Septin2 macrophages aortic dissection.
The cardiac-protective role of GSNOR (S-nitrosoglutathione reductase) in the cytoplasm, as a denitrosylase enzyme S-nitrosylation, has been reported cardiac remodeling, but whether is localized other organelles and exerts novel effects remains unknown. We aimed to elucidate mitochondrial GSNOR, subcellular localization on remodeling heart failure (HF).
G protein-coupled receptors play a critical role in atrial fibrillation (AF). Spexin is novel ligand of galanin (GALRs). In this study, we investigated the regulation spexin and GALRs on AF underlying mechanisms.
Background Hydrogen sulfide (H 2 S) is a gasotransmitter that regulates multiple cardiovascular functions. Krüppel‐like factor 5 (KLF5) exerts diverse functions in the system. Whether and how H S KLF5 myocardial hypertrophy unknown. Methods Results In our study, hypertrophic samples clinic were collected underwent histological molecular biological analysis. Spontaneously hypertensive rats neonatal rat cardiomyocytes studied for functional signaling responses to GYY4137, an S‐releasing...
The transcriptional changes around zygotic genome activation (ZGA) in preimplantation embryos are critical for studying mechanisms of embryonic developmental arrest and searching key transcription factors. However, studies on the profile porcine ZGA limited.In this study, we performed RNA sequencing vivo developed (IVV) somatic cell nuclear transfer (SCNT) embryo at different stages compared activity with mouse, bovine human embryos. results showed that transcriptome map early was...
Aortic aneurysm is a life-threatening disease with limited interventions that closely related to vascular smooth muscle cell (VSMC) phenotypic switching. SLC44A2, member of the solute carrier series 44 (SLC44) family, remains undercharacterized in context cardiovascular diseases. Venn diagram analysis based on microarray and single-cell RNA sequencing identified SLC44A2 as major regulator VSMC switching aortic aneurysm. Screening for Slc44a2 among lineages demonstrated its predominant...
Abstract The risk for suffering immune checkpoint inhibitors (ICIs)‐associated myocarditis increases in patients with pre‐existing conditions and the mechanisms remain to be clarified. Spatial transcriptomics, single‐cell RNA sequencing, flow cytometry are used decipher how anti‐cytotoxic T lymphocyte antigen‐4 m2a antibody (anti‐CTLA‐4 antibody) aggravated cardiac injury experimental autoimmune (EAM) mice. It is found that anti‐CTLA‐4 fibroblast‐derived C‐X‐C motif chemokine ligand 1...
Background and purpose: Ponatinib, a tyrosine kinase inhibitor (TKI) leads to hypertension; however, the mechanisms remain elusive. We aimed investigate whether lysine acetyltransferase 7 (KAT7), key regulator of cellular senescence that is closely associated with cardiovascular diseases, involves in ponatinib-induced hypertension. Methods results: After administering ponatinib Sprague–Dawley (SD) rats for 8 days, we measured blood pressure, vasodilation, endothelial function using tail-cuff...
An increasing number of mechano-sensitive ion channels in endothelial cells have been identified response to blood flow and hydrostatic pressure. However, how these respond under different physiological pathological conditions remains unknown. Our results show that epithelial Na(+) (ENaCs) colocalize with hemeoxygenase-1 (HO-1) hemeoxygenase-2 (HO-2) within the caveolae on apical membrane are sensitive stretch pressure shear stress. ENaCs exhibited low levels activity until their environment...
Aberrant hedgehog signaling contributes to the development of various malignancies, including glioblastoma (GBM). However, potential mechanism in GBM migration and invasion has remained be elucidated. The present study showed that enhanced by recombinant human sonic N‑terminal peptide (rhSHH) promoted adhesion, cells, accompanied increases mRNA protein levels matrix metalloproteinase‑2 (MMP‑2) MMP‑9. inhibition with cyclopamine suppressed decreases MMP‑2 ‑9. Furthermore, it was found MMP‑2-...
This study was designed to investigate the effects and mechanism of action traditional Chinese drug formula, qiliqiangxin (QLQX), on cardiac function in spontaneously hypertensive rats (SHRs). We evaluated oral high-dose (4g/kg/day, n = 7) low-dose (1g/kg/day, QLQX SHRs aged between 8 compared control, 8-week-old Wistar–Kyoto (WKY) rats. Echocardiography performed evaluate hemodynamic parameters. Hematoxylin eosin (HE) Masson's trichrome staining were performed, expression myocardial...
Background and Purpose The molecular identity of calcium‐activated chloride channels ( C a CC s) in vascular endothelial cells remains unknown. This study sought to identify whether anoctamin‐1 Ano 1, also known as TMEM 16 A ) functions CaCC hypoxia alters the biophysical properties 1 mouse cardiac CVECs ). Experimental Approach Western blot, quantitative real‐time PCR , confocal imaging analysis patch‐clamp combined with pharmacological approaches were used determine was expressed...
Background and Purpose The epithelial sodium channel ( ENaC ) is expressed in vascular endothelial cells a negative modulator of vasodilation. However, the role ENaCs salt‐sensitive hypertension remains unclear. Here, we have investigated how Sprague‐Dawley SD rats respond to high‐salt HS challenge. Experimental Approach BP plasma aldosterone levels were measured. We used patch‐clamp technique record activity split‐open mesenteric arteries MAs ). Western blot G riess assay detect expression...
Atherosclerosis is a chronic inflammatory cardiovascular disease. Macrophages are major components of atherosclerotic plaques and play key role in the development atherosclerosis by secreting variety pro-inflammatory factors. Our previous studies have confirmed that upconversion nanoparticles encapsulating chlorin e6 (UCNPs-Ce6) mediated photodynamic therapy (PDT) can promote cholesterol efflux induce apoptosis THP-1 macrophages. In this study, we investigated whether reactive oxygen species...