Abstract Background Sarcopenia is a decrease in skeletal muscle mass, physical performance, and strength older people. In this study, we aimed to explore the correlation between comorbidity mass performance Methods This retrospective study included 168 subjects. Their medical history, function, computed tomography (CT) chest scans, blood tests for nutrition were evaluated. The patients divided into two groups: (1) low group (2) normal group. Multivariate analysis of variance was used compare...

The age-adjusted Charlson comorbidity index (ACCI) is a useful measure of to standardize the evaluation elderly patients and has been reported predict mortality in various cancers. To our best knowledge, no studies have examined relationship between ACCI survival with cancer. Therefore, primary objective this study was investigate cancer.A total 64 (>80 years) cancer 2011 2021 were enrolled study. According ACCI, calculated by weighting individual comorbidities; ACCI<11 considered low-ACCI...

An increasing number of mechano-sensitive ion channels in endothelial cells have been identified response to blood flow and hydrostatic pressure. However, how these respond under different physiological pathological conditions remains unknown. Our results show that epithelial Na(+) (ENaCs) colocalize with hemeoxygenase-1 (HO-1) hemeoxygenase-2 (HO-2) within the caveolae on apical membrane are sensitive stretch pressure shear stress. ENaCs exhibited low levels activity until their environment...

Objectives: This study investigated the relationship between serum 25-Hydroxyvitamin D [25(OH)D] levels, vitamin receptor (VDR) gene polymorphisms, and prognosis of acute pancreatitis (AP). Methods: prospective observation included patients with AP admitted to Jinling Hospital January 2018 December 2019. Clinical information, laboratory tests, single nucleotide polymorphisms (SNPs) VDR were collected. Results: A total 508 included, a mean age 44.81 ± 13.80 years. Among them, 158 (31.10%)...

The two most common surgical interventions for spontaneous intracerebral hemorrhage in the basal ganglia of patients more than 65 years old are either minimally invasive puncture and drainage or craniotomy. This study aimed to compare curative effects these procedures such patients. A retrospective older with was conducted between January 2012 December 2015. Of 86 patients, 47 received 39 underwent One year after surgery no statistically significant difference observed groups respect to:...

Sepsis is a life-threatening organ dysfunction caused by the host's imbalance in response to infection, which still leading cause of death critically ill patients. In recent years, studies have found that vitamin D deficiency or insufficiency common patients, especially sepsis. The relationship between and sepsis has attracted more attention. mechanism described from aspects immune regulation, inflammation endothelial cell protection, carbon monoxide receptor gene polymorphism, analyzing...

Glycoprotein VI (GPVI) is the major signaling receptor for collagen on platelets. Recent studies suggest that surface density of GPVI related to activation platelets by collagen. To measure level platelets, a mouse polyclonal antibody BJ010 was prepared using an amplified fragment extracellular domain in GPVI. The specific reactivity identified anti-GPVI monoclonal 11a12 immunoprecipitation, sandwich enzyme-linked immunosorbent assay (ELISA) and flow cytometry. recognized both native...

While current coronary intervention therapies and surgical bypass procedures are widely utilized, the treatment of acute myocardial infarction (AMI) in elderly continues to pose significant challenges. Following AMI, body's immune system is activated, resulting release inflammatory mediators that exacerbate damage. Interleukin 28A (IL28A) interleukin 28B (IL28B) may play a role regulation post-AMI by specifically binding 28 receptor alpha (IL28RA). However, precise underlying mechanisms...

Peroxisome proliferator-activated receptor-γ (PPARγ) is a regulator of inflammation. This study aimed to explore associations between PPARγ gene single-nucleotide polymorphisms (SNPs) and susceptibility clinical outcome sepsis in the North China Han population.This included 303 patients with controls. We conducted genetic typing for 13 common SNPs (improved multiplex ligation detection reaction), linkage disequilibrium mapping, haplotype inference. Associations SNP genotypes/haplotypes...

Acute myocardial infarction (AMI) can be complicated by multiple organ dysfunction syndrome (MODS), but the exact influence of MODS on AMI remains unclear.This was a retrospective study 6674 Chinese patients with AMI. The impact assessed using Cox proportional hazard model. Using occurrence as outcome, prediction model developed factors identified logistic regression analysis and analyzed receiving operator characteristic curves.Of AMI, 83 (1.2%) progressed to MODS. independently predicted...

Objective: To investigated p53 gene mutation in plasma of gastric cancer patients. Methods: DNA extracted from and matched tumor tumor-adjacent non-cancerous tissues 96 patients, 20 healthy volunteers were studied. Exon 5, 6, 7, 8 amplified by Polymerase Chain Reaction (PCR). The status was analyzed denaturing high-performance liquid chromatography (DHPLC), followed direct sequencing cases with aberrant chromatographic patterns. Results: Heterozygous mutations detected 19.9% (19/96) primary...

As the rate of gene discovery accelerates, more efficient methods are needed to analyze genes in human tissues. Genechip, a kind new device, is composed DNA probes immobilized on solid substrate. With advantage high throughput information, genechip has become one best solutions detect and analyse mutations genes. Hypertrophic cardiomyopathy (HCM), most common cause sudden death young, diseases damaging people health badly. It an autosomal dominant disease. More than 55% HCM patients genetic....

Objective To investigate the effect of sarcopenia on efficiency treatment femoral neck fracture in elderly patients. Methods A total 65 patients aged ≥65 years with fractures meeting inclusion and exclusion criteria were investigated our hospital from February 2014 to 2016.The muscle cross-sectional area(cm2)at thoracic 12 pedicle level was measured by chest CT.The skeletal index(SMI)is calculated formula that T12 divided m2 patient's body height(meter). SMI cutoff values 42.6...

Objective To explore the correlation between comorbidity index and sarcopenia in elderly patients. Methods Sixty-five patients over 80 years old were included this study. Chest CT was used to measure cross-sectional area (cm2) muscle density (HU) of tissue at pedicle level 12 thoracic vertebral (T12). The skeletal (TSMI) calculated by dividing cross sectional T12 with height patient. difference Charlson (CCI), BMI laboratory indexes non analyzed t test. different age groups, CCI...

Early diagnosis and prompt treatment are mandatory to prevent colorectal cancer. Detection of free circulating tumor DNA in the serum cancer patients provides new possibilities for diagnosis. Several DNAs have been identified by PCR detection such as activated K-ras oncogene, inactivated APC, p53 genes, microsatellite instability (MSI). Circulating was predominantly found with advanced disease poor prognosis. It suggested that analysis might be useful early