A5048186002- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Systemic Lupus Erythematosus Research
- Neurogenesis and neuroplasticity mechanisms
- Structural Behavior of Reinforced Concrete
- Acute Lymphoblastic Leukemia research
- Neural Networks and Applications
- Immunotherapy and Immune Responses
- Rheumatoid Arthritis Research and Therapies
- Advanced Neuroimaging Techniques and Applications
- Autoimmune Neurological Disorders and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Cytokine Signaling Pathways and Interactions
- Fuzzy Logic and Control Systems
- T-cell and B-cell Immunology
- CNS Lymphoma Diagnosis and Treatment
- Neurosurgical Procedures and Complications
- Target Tracking and Data Fusion in Sensor Networks
- Immune Cell Function and Interaction
- Tryptophan and brain disorders
- Cerebrovascular and genetic disorders
- Vasculitis and related conditions
- Genetics and Neurodevelopmental Disorders
- Higher Education and Teaching Methods
Capital Medical University
2016-2025
Beijing Tian Tan Hospital
2016-2025
National Clinical Research Center for Digestive Diseases
2018-2024
Nanjing University
2017-2024
Nanjing General Hospital of Nanjing Military Command
2017-2024
Tianjin Medical University General Hospital
2020-2024
First Hospital of Shanxi Medical University
2020-2024
Shanxi Medical University
2020-2024
Nanjing Medical University
2022-2024
Southern Medical University
2024
Disease-modifying drugs (DMDs) may alter the immune status and thus increase susceptibility to coronavirus disease 2019 (COVID-19) in patients with MS or neuromyelitis optica spectrum disorders (NMOSD). However, evidence supporting this notion is currently lacking. In study, we conducted a survey on risk of COVID-19 NMOSD.The was through Chinese Medical Network for Neuroinflammation. Patients 10 centers from 8 cities including Wuhan were included. Information about NMOSD duration usage DMDs...
This study aimed to investigate the clinical efficacy and safety of telitacicept in patients with generalized myasthenia gravis (gMG) who tested positive for acetylcholine receptor antibodies or muscle-specific kinase were receiving standard-of-care therapy.
Abstract Background Sarcopenia is a decrease in skeletal muscle mass, physical performance, and strength older people. In this study, we aimed to explore the correlation between comorbidity mass performance Methods This retrospective study included 168 subjects. Their medical history, function, computed tomography (CT) chest scans, blood tests for nutrition were evaluated. The patients divided into two groups: (1) low group (2) normal group. Multivariate analysis of variance was used compare...
The age-adjusted Charlson comorbidity index (ACCI) is a useful measure of to standardize the evaluation elderly patients and has been reported predict mortality in various cancers. To our best knowledge, no studies have examined relationship between ACCI survival with cancer. Therefore, primary objective this study was investigate cancer.A total 64 (>80 years) cancer 2011 2021 were enrolled study. According ACCI, calculated by weighting individual comorbidities; ACCI<11 considered low-ACCI...
Laboratory determination of autoantibodies against acetylcholine receptor (AChR), muscle-specific kinase (MuSK) and other autoantigens have been integrated into the diagnosis myasthenia gravis (MG). However, evidence supporting selection methodologies is lacking.In this prospective, multicentre cohort study, we recruited patients with suspected MG to evaluate diagnostic accuracy cell-based assay (CBA), radioimmunoprecipitation (RIPA) enzyme-linked immunosorbent (ELISA) in detecting AChR MuSK...
Metabolic characterization of primary angiitis the central nervous system (PACNS) is crucial for understanding disease pathogenesis and progression mechanisms, but it has not been reported in patients. This study aimed to explore changes plasma metabolome during active remission phases PACNS identify potential biomarkers. We collected samples from 35 patients with 22 non-inflammatory as controls. Liquid gas chromatography-mass spectrometry were used analyze 63 57 metabolically. Meanwhile, we...
Background Brain structural alterations and their clinical significance of myelin oligodendrocyte glycoprotein antibody disease (MOGAD) have not been determined. Methods We recruited 35 MOGAD, 38 aquaporin 4 positive neuromyelitis optica spectrum diseases (AQP4+ NMOSD), 37 multiple sclerosis (MS) 60 healthy controls (HC) who underwent multimodal brain MRI from two centres. lesions, volumes the whole parenchyma, cortical subcortical grey matter (GM), brainstem, cerebellum cerebral white (WM)...
Objectives To assess the efficacy and safety of rituximab (RTX) in Chinese patients with primary angiitis central nervous system (PACNS). Methods Herein, we present outcomes 8 who received RTX for PACNS. Seven underwent a brain biopsy showing vasculitis, while remaining patient had digital subtraction angiogram clinical findings highly suggestive vasculitis. Clinical evaluation, laboratory tests, imaging modalities were performed during initial administration follow-up. The Expanded...
Abstract Background The cerebellum plays key roles in the pathology of multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD), but way which these conditions affect how communicates with rest brain (its connectome) associated genetic correlates remains largely unknown. Methods Combining multimodal MRI data from 208 MS patients, 200 NMOSD patients 228 healthy controls brain-wide transcriptional data, this study characterized convergent divergent alterations...
A novel and efficient protocol for the construction of trifluoroethyl pyrazolines has been developed by cascade cyclization/trifluoromethylation reaction β,γ-unsaturated hydrazones. This strategy uses cheap commercially available trichloroisocyanuric acid as promoter TMSCF3 trifluoromethylating reagent, which make process much cheaper. wide range substrates can be applied in this to afford good yield.
<b><i>Objective:</i></b> We investigated the contribution of several cytokines in pathogenesis first-onset neuromyelitis optica spectrum disorder (NMOSD) and determined differences between aquaporin 4 immunoglobulin G (AQP4-IgG)-positive AQP4-IgG-negative subtypes. <b><i>Methods:</i></b> enrolled 18 NMOSD (10 AQP4-IgG-positive 8 AQP4-IgG-negative) multiple sclerosis (MS) patients, whose serum cerebrospinal fluid (CSF) samples were collected...
Accurate differentiation of intramedullary spinal cord tumors and inflammatory demyelinating lesions their subtypes are warranted because overlapping characteristics at MRI but with different treatments prognosis. The authors aimed to develop a pipeline for lesion segmentation classification using two-dimensional MultiResUNet DenseNet121 networks based on T2-weighted images. A retrospective cohort 490 patients (118 astrocytoma, 130 ependymoma, 101 multiple sclerosis [MS], 141 neuromyelitis...
Background Although trigeminal nerve involvement is a characteristic of multiple sclerosis (MS), its prevalence across studies varies greatly due to MRI resolution and cohort selection bias. The mechanism behind the site specificity injury still unclear. We aim determine in patients with MS consecutive 7T brain cohort. Methods This observational originates from an ongoing China National Registry Neuro-Inflammatory Diseases. Inclusion criteria were following: age 18 years or older, diagnosis...
To identify predictors for relapse in patients with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) and to develop validate a simple risk score predicting relapse.
This paper discusses the Delta-rule and training of min-max neural networks by developing a differentiation theory for functions, functions containing min (wedge) and/or max (V) operations. We first prove that under certain conditions all are continuously differentiable almost everywhere in real number field R derive explicit formulas differentiation. These results basis networks. The convergence new is proved theoretically using stochastic theory, demonstrated with simulation example.