A5100712691- Multiple Sclerosis Research Studies
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Immune Response and Inflammation
- Cytomegalovirus and herpesvirus research
- Peripheral Neuropathies and Disorders
- Adipose Tissue and Metabolism
- Brain Metastases and Treatment
- Neurogenesis and neuroplasticity mechanisms
- Systemic Lupus Erythematosus Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Animal Behavior and Welfare Studies
- Immunotherapy and Immune Responses
- Meningioma and schwannoma management
- Regulation of Appetite and Obesity
- Selenium in Biological Systems
- Insect Utilization and Effects
- Tuberculosis Research and Epidemiology
- Anesthesia and Pain Management
- Amyotrophic Lateral Sclerosis Research
- vaccines and immunoinformatics approaches
- Hydrogen Storage and Materials
- Cloud Computing and Resource Management
- Primate Behavior and Ecology
Tianjin Medical University General Hospital
2019-2024
Yale University
2021-2024
Shandong Academy of Sciences
2024
Qilu University of Technology
2024
Tsinghua University
2020-2023
National Medical Products Administration
2023
Beijing Forestry University
2016-2022
Sun Yat-sen University
2021
National Clinical Research Center for Digestive Diseases
2021
Capital Medical University
2021
Abstract NK cells respond to tumor and virus-infected directly through several activation receptors, including natural cytotoxicity or indirectly the activating Fc receptor CD16 for antibody-coated cells. Triggering of NK-cell effector functions these receptors depends on physically associated transmembrane signaling adaptors, such as FcRγ (also known FcεRIγ) CD3ζ, both which have been traditionally believed be expressed by all mature However, we identified a distinct subset human that are...
Abstract Background Malignant meningiomas are fatal and lack effective therapy. As M2 macrophages the most prevalent immune cell type in human meningiomas, we hypothesized that normalizing this immunosuppressive population would be an treatment strategy. Methods We used CIBERSORTx to examine proportions of 22 subsets meningiomas. targeted colony-stimulating factor 1 (CSF1) or CSF1 receptor (CSF1R) axis, important regulator macrophage phenotype, using monoclonal antibodies (mAbs) a novel...
Abstract Background Plasma amyloid-β (Aβ) peptides and tau proteins are promising biomarkers of Alzheimer’s disease (AD), not only for predicting Aβ pathology but also differentiating AD from other neurodegenerative diseases. However, reference intervals plasma in healthy elderly Chinese individuals have yet been established. Methods Biomarkers were measured using single-molecule array (Simoa) assays samples 193 healthy, cognitively unimpaired aged 50–89 years. The 95% Aβ42, Aβ40, t-tau,...
ABSTRACT Background and Objectives Ofatumumab, a fully human anti‐CD20 monoclonal antibody, is effective in reducing relapses disability progression patients with multiple sclerosis. This study aimed to examine immune profile changes associated ofatumumab prospective cohort of Chinese relapsing–remitting sclerosis (RRMS). Methods Seventeen RRMS were enrolled this uncontrolled, prospective, observational (OMNISCIENCE study) received regular subcutaneous treatments. Immune cell subsets...
<h3>Background and Objectives</h3> To assess the molecular landscape of B-cell subpopulations across different compartments in patients with neuromyelitis optica spectrum disorder (NMOSD). <h3>Methods</h3> We performed transcriptomic profiles via single-cell RNA sequencing CSF, blood, bone marrow NMOSD. <h3>Results</h3> Across tissue types tested, 4 major B cells distinct signatures were identified: naive cells, memory age-associated antibody-secreting (ASCs). NMOSD show proinflammatory...
Abstract Background Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory autoimmune disease of the central nervous system that involves B-cell receptor signaling as well astrocyte–microglia interaction, which both contribute to evolution NMOSD lesions. Main body Through transcriptomic and flow cytometry analyses, we found Bruton’s tyrosine kinase (BTK), a crucial protein was upregulated in blood cerebrospinal fluid patients. Blockade BTK with zanubrutinib, highly specific...
This study is aimed to evaluate the safety, tolerability, and pharmacokinetics (PK), as well select an appropriate dosing regimen for pivotal clinical trial of GST-HG171, orally bioavailable, potent, selective 3CL protease inhibitor by a randomized, double-blind, placebo-controlled phase I in healthy subjects. We conducted Ph1 involving 78 subjects assess PK single ascending doses (150-900 mg) multiple (MADs) (150 300 GST-HG171. Additionally, we examined food effect drug-drug interaction...
Neurofilament light chain (NfL) and glial fibrilliary acidic protein (GFAP) have been suggested to be biomarkers of the pathophysiological process neuromyelitis optica spectrum disorders (NMOSD), but relationship between plasma levels these molecules with disease activity treatment is incompletely understood.To investigate effects disease-modifying drugs on neurofilament (pNfL) fibrillary (pGFAP) explore predictive value pNfL pGFAP in NMOSD.pNfL were measured using single-molecule arrays 72...
Background Interleukin-6 receptor blockade is effective in reducing the risk of relapses neuromyelitis optica spectrum disorder (NMOSD). However, its efficacy during acute attacks NMOSD remains elusive. Objective We investigated effects tocilizumab on disability attacks, as well maintenance, patients with moderate-to-severe myelitis. Methods Nineteen received treatment add-on to high-dose methylprednisolone (HDMP) myelitis and twenty-two who only HDMP were compared. Disease was assessed...
Musk is a secreted external hormone or information compound that stored in musk scent glands of the males species within family Moschidae, such as Moschus berezovskii. The secretion changes periodically during courtship and reproduction periods, with early stage occurring from May to July, maturation August April following year. In this study, we analyzed dynamic components June result showed morphological character, water content, total ion chromatographic pattern, composition undergo...
Tocilizumab, a humanized anti-IL-6 receptor monoclonal antibody, showed its therapeutic efficacy on neuromyelitis optica spectrum disorder (NMOSD). To assess the immunological effects of this drug B cells, follicular T helper (Tfh) and peripheral (Tph) cells in patients with NMOSD, cell Tfh phenotypes were evaluated 26 NMOSD before after tocilizumab treatment by nine-color flow cytometry, as well expression costimulatory co-inhibitory molecules cells. Results that frequency CD27 + IgD −...
Abstract The immunological status of human meningiomas is not well understood, hindering the development rational immunotherapeutic strategies. We measured levels PD-L1, PD-L2, and immune cell subsets using multiplex quantitative immunofluorescence in a tissue microarray composed 73 (56 WHO Grade 1, 13 2, 4 3). analyzed tumor-infiltrating populations, T-cell activation/dysfunction, macrophage phenotypes. PD-L1 PD-L2 were detected 5.8% 68.7% cases, respectively. There was higher expression...
The musk gland in an adult male forest deer is organ that synthesizes, stores, and secretes musk, a cream-colored liquid upon initial secretion gradually transforms into blackish-brown solid substance full maturation. In this study, four healthy were selected total of 12 samples collected for analysis. three different states depending on the seasonal collection dates, which June, August, October. High-throughput 16S-rRNA gene sequencing technology was used to detect microbiota changes gland....
Abstract With the continuous development and combined application of cloud computing artificial intelligence, some new methods have emerged to reduce task execution time for training neural network models in a cloud-edge collaborative environment. The most attractive method is model segmentation. However, many factors affect segmentation point, such as resource allocation, system energy consumption, load balancing, Bandwidth allocation. Some consider shortest time, which ignores utilization...
Autoreactive CD4+ helper T cells are implicated in the pathogenesis of neuromyelitis optica spectrum disorder (NMOSD). Both PD-1+CXCR5+CD4+ follicular (Tfh) and PD-1+CXCR5-CD4+ peripheral (Tph) can contribute to B-cell immune responses production antibodies. Here we show effect depletion with rituximab on homeostasis Tfh cells, Tph their subsets patients NMOSD. After treatment, total Tph17 Tph17.1 Tph1 Tfh1 tended decrease at month 1, but gradually increased 6 restored 12. Besides, Tfh17.1...
FcRγ-deficient natural killer (NK) cells, designated as g-NK exhibit enhanced antibody-dependent cellular cytotoxicity (ADCC) capacity and increased IFN-γ TNF-α production, rendering them promising for antiviral antitumor responses. cells from peripheral blood (PB) are often associated with prior human cytomegalovirus (HCMV) infection. However, the prevalence, phenotype, function of in umbilical cord (UCB-g-NK) remain unclear. Here, we demonstrate significant phenotypical differences between...
Adult male muskrats (Ondatra zibethicus) secret musk from their scent glands to attract females for seasonal mating. The goal of the present study was investigate whether changes in energy metabolism related secretion during breeding and non-breeding seasons are mediated by adiponectin. We found that season markedly greater than season. serum adiponectin concentration measured using an ELISA kit higher Glandular cells, interstitial epithelial cells glandular cavities were detected...