A5057361924- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Dermatology and Skin Diseases
- Ubiquitin and proteasome pathways
- Immune cells in cancer
- CAR-T cell therapy research
- Autoimmune and Inflammatory Disorders Research
- Gut microbiota and health
- Agroforestry and silvopastoral systems
- Cytomegalovirus and herpesvirus research
- Psoriasis: Treatment and Pathogenesis
- Nanocluster Synthesis and Applications
- Cancer Immunotherapy and Biomarkers
- Mesenchymal stem cell research
- Osteoarthritis Treatment and Mechanisms
- Immunotherapy and Immune Responses
- Gold and Silver Nanoparticles Synthesis and Applications
- Soil Carbon and Nitrogen Dynamics
- Lymphoma Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Heavy Metals in Plants
- GDF15 and Related Biomarkers
- Herpesvirus Infections and Treatments
Université de Montpellier
2019-2024
Inserm
2019-2024
Scripps (United States)
2022-2024
Scripps Institution of Oceanography
2022-2024
National Institute of Allergy and Infectious Diseases
2016-2021
National Institutes of Health
2017-2021
Institute for Regenerative Medicine & Biotherapy
2020
Heidelberg University
2019
University Hospital Heidelberg
2019
German Cancer Research Center
2019
Commensals rule the MAITrix Mucosal-associated invariant T (MAIT) cells play an important role in mucosal homeostasis. MAIT recognize microbial small molecules presented by major histocompatibility complex class Ib molecule MR1. are absent germ-free mice, and mechanisms which microbiota control cell development unknown (see Perspective Oh Unutmaz). Legoux et al. show that, of within thymus is governed bacterial product 5-(2-oxopropylideneamino)-6- d -ribitylaminouracil, rapidly traffics from...
How defined microbes influence the skin immune system remains poorly understood. Here we demonstrate that Corynebacteria, dominant members of microbiota, promote a dramatic increase in number and activation subset γδ T cells. This effect is long-lasting, occurs independently other microbes, is, part, mediated by interleukin (IL)-23. Under steady-state conditions, impact Corynebacterium discrete noninflammatory. However, when applied to host fed high-fat diet, accolens alone promotes...
The microbiota plays a fundamental role in regulating host immunity. However, the processes involved initiation and regulation of immunity to remain largely unknown. Here, we show that skin promotes discrete expression defined endogenous retroviruses (ERVs). Keratinocyte-intrinsic responses ERVs depended on cyclic GMP-AMP synthase (cGAS)/stimulator interferon genes protein (STING) signaling promoted induction commensal-specific T cells. Inhibition ERV reverse transcription significantly...
Innate-like NKT cells conspicuously accumulate within the liver microvasculature of healthy mice, crawling on luminal side endothelial cells, but their general recirculation pattern and mechanism intravascular behavior have not been elucidated. Using parabiotic we demonstrated that, despite location, most failed to recirculate. Antibody blocking experiments established that they were retained locally through constitutive LFA-1–intercellular adhesion molecule (ICAM) 1 interactions. This...
Significance Diverse populations of group 1 innate lymphocytes, which exert critical early cytolytic functions against virally infected cells, have recently been discovered, raising issues lineage relationships. We used expression the transcription factor promyelocytic leukaemia zinc finger (PLZF) to identify developmental intermediates lymphoid cells type (ILC1s), a subset that are particularly abundant in liver, and demonstrated this arises from distinct precursor, but its development...
The transcription factor PLZF [promyelocytic leukemia zinc finger, encoded by finger BTB domain containing 16 (Zbtb16)] is induced during the development of innate and innate-like lymphocytes to direct their acquisition a T-helper effector program, but molecular mechanisms involved are poorly understood. Using biotinylation-based ChIP-seq microarray analysis both natural killer T (NKT) cells PLZF-transgenic thymocytes, we identified several layers regulation NKT program. First, bound...
α-Galactosylceramide represents a new class of vaccine adjuvants and immunomodulators that stimulate NKT cells to secrete Th1 Th2 cytokines. Synthetic variants with short or unsaturated acyl chains exhibit striking bias in vivo but no evidence defect TCR signaling stimulation vitro. Using cd1d1(fl/fl) mice, we demonstrated distinct APC types explained the cytokine vivo. Whereas by required CD1d expression dendritic (DCs), presentation was promiscuous unaffected DC-specific ablation CD1d....
Tissue accumulation of p16INK4a-positive senescent cells is associated with age-related disorders, such as osteoarthritis (OA). These cell-cycle arrested affect tissue function through a specific secretory phenotype. The links between OA onset and senescence remain poorly described. Using experimental protocol transgenic Cdkn2a+/luc Cdkn2aluc/luc mice, we found that the senescence-driving p16INK4a marker disease, expressed by synovial tissue, but also an actor: its somatic deletion partially...
The cross-talk between the microbiota and immune system plays a fundamental role in control of host physiology. However, tissue-specific factors controlling this dialogue remain poorly understood. Here we demonstrate that T cell responses to commensal colonization are associated with development organized cellular clusters within skin epithelium. These lymphocyte surrounded by keratinocytes expressing discrete program antigen presentation antimicrobial defense. Notably, IL-22–mediated...
Leukemic cells proliferate faster than non-transformed counterparts. This requires them to change their metabolism adapt high growth. can stress and facilitate recognition by immune such as cytotoxic lymphocytes, which express the activating receptor Natural Killer G2-D (NKG2D). The tumor suppressor gene p53 regulates cell metabolism, but its role in expression of metabolism-induced ligands, subsequent is unknown. We show here that dichloroacetate (DCA), induces oxidative phosphorylation...
Abstract Thymocytes expressing the NKT cell semi-invariant αβ TCR are thought to undergo agonist interactions with CD1d ligands prior promyelocytic leukemia zinc finger (PLZF), a broad complex, tramtrack, bric-a-brac, poxvirus, and transcription factor that directs acquisition of effector program these innate-like T cells. Whether PLZF can mediate this conversion independently signaling has not been investigated. We demonstrated transgenic (Tg) expression under CD4 promoter induced innate in...
In this study we evaluated the potential of expanded NK cells (eNKs) from two sources combined with mAbs daratumumab and pembrolizumab to target primary multiple myeloma (MM) ex vivo. order ascertain best source cells, activated peripheral blood (PB) healthy adult donors umbilical cord (UCB). The resulting (eNK) express CD16, necessary for carrying out antibody-dependent cellular cytotoxicity (ADCC). Cytotoxicity assays were performed on bone marrow aspirates 18 MM patients 4 monoclonal...
Abstract Rare CD1d-α-galactosylceramide–specific T cells that do not express the invariant Vα24 chain of human NKT were recently identified after expansion in vitro with lipid Ag, but their phenotype and frequency vivo lineage relationship could be elucidated. By using a CD1d tetramer-based method to enrich these from fresh peripheral blood, we demonstrated naive-like CD62LhighCD45RO−CD4+ relatively high ∼10−5 several healthy individuals. Notably, expressed lineage-specific transcription...
Induction of Bcl6 (B cell lymphoma 6) is essential for T follicular helper (Tfh) differentiation antigen-stimulated CD4+ cells. Intriguingly, we found that was also highly and transiently expressed during the CD4+CD8+ (double positive [DP]) stage development, in association with E3 ligase cullin 3 (Cul3), a novel binding partner which ubiquitinates histone proteins. DP stage–specific deletion Cul3, or Bcl6, induced derepression target genes Batf (basic leucine zipper transcription factor,...