A5066999466- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Gut microbiota and health
- Eosinophilic Esophagitis
- T-cell and B-cell Immunology
- Immune responses and vaccinations
- Infectious Aortic and Vascular Conditions
- Acute Kidney Injury Research
- Reproductive System and Pregnancy
- Dermatology and Skin Diseases
- Epigenetics and DNA Methylation
- Neuropeptides and Animal Physiology
- Child Nutrition and Water Access
- Vagus Nerve Stimulation Research
- Immunodeficiency and Autoimmune Disorders
- Cancer, Stress, Anesthesia, and Immune Response
- COVID-19 Impact on Reproduction
- Chronic Kidney Disease and Diabetes
- Single-cell and spatial transcriptomics
- Clostridium difficile and Clostridium perfringens research
- Asthma and respiratory diseases
- Prenatal Screening and Diagnostics
- NF-κB Signaling Pathways
- Immune Response and Inflammation
- Birth, Development, and Health
Princeton University
2023-2025
National Institute of Allergy and Infectious Diseases
2019-2024
National Institutes of Health
2021-2024
Cornell University
2023
Weill Cornell Medicine
2023
ActionAid
2023
Government of the United States of America
2022
Institut Pasteur
2016-2021
Inserm
2016-2018
Sorbonne Paris Cité
2017
Group 2 innate lymphoid cells (ILC2) include IL-5– and IL-13–producing CRTh2+CD127+ that are implicated in early protective immunity at mucosal surfaces. Whereas functional plasticity has been demonstrated for both human mouse ILC3 subsets can reversibly give rise to IFN-γ–producing ILC1, of or ILC2 not shown. Here, we analyze the phenotypic heterogeneity peripheral blood ILC2. Although CRTh2+ differentially express CD117 (c-kit receptor), some surface phenotypes unstable be modulated vitro....
Heterozygosity for human signal transducer and activator of transcription 3 (STAT3) dominant-negative (DN) mutations underlies an autosomal dominant form hyper-immunoglobulin E syndrome (HIES). We describe patients with recessive HIES due to loss-of-function a previously uncharacterized gene, ZNF341 is factor that resides in the nucleus, where it binds specific DNA motif present various genes, including STAT3 promoter. The patients' cells have low basal levels mRNA protein. autoinduction...
The immune system has evolved in the face of microbial exposure. How maternal infection experienced at distinct developmental stages shapes offspring remains poorly understood. Here, we show that during pregnancy, maternally restricted can have permanent and tissue-specific impacts on immunity. Mechanistically, interleukin-6 produced response to directly impose epigenetic changes fetal intestinal epithelial stem cells, leading long-lasting homeostasis. As a result, previously infected dams...
The microbiota plays a fundamental role in regulating host immunity. However, the processes involved initiation and regulation of immunity to remain largely unknown. Here, we show that skin promotes discrete expression defined endogenous retroviruses (ERVs). Keratinocyte-intrinsic responses ERVs depended on cyclic GMP-AMP synthase (cGAS)/stimulator interferon genes protein (STING) signaling promoted induction commensal-specific T cells. Inhibition ERV reverse transcription significantly...
Males and females exhibit profound differences in immune responses disease susceptibility. However, the factors responsible for sex tissue immunity remain poorly understood. Here, we uncovered a dominant role type 2 innate lymphoid cells (ILC2s) shaping sexual dimorphism within skin. Mechanistically, negative regulation of ILC2s by androgens leads to reduction dendritic cell accumulation activation males, along with reduced immunity. Collectively, our results reveal androgen-ILC2-dendritic...
The somatosensory nervous system surveils external stimuli at barrier tissues, regulating innate immune cells under infection and inflammation. roles of sensory neurons in controlling the adaptive system, more specifically immunity to microbiota, however, remain elusive. Here, we identified a mechanism for direct neuroimmune communication between commensal-specific T lymphocytes mediated by neuropeptide calcitonin gene–related peptide (CGRP) skin. Intravital imaging revealed that are close...
Abstract While patient selection and clinical management have reduced high-dose IL-2 (HDIL2) immunotherapy toxicities, the immune mechanisms that underlie HDIL2-induced morbidity remain unclear. Here we show dose-dependent mortality of can be modeled in human system (HIS) mice. Depletion T cell subsets during HDIL2 treatment reduces toxicity, pointing to central function cells. Preferential expansion effector cells secondary defective suppressive capacity regulatory (T reg ) after therapy...
We studied a child with severe viral, bacterial, fungal, and parasitic diseases, who was homozygous for loss-of-function mutation of REL, encoding c-Rel, which is selectively expressed in lymphoid myeloid cells. The patient had low frequencies NK, effector memory cells reexpressing CD45RA (Temra) CD8+ T cells, CD4+ including Th1 Th1*, Tregs, B whereas the counts proportions other leukocyte subsets were normal. Functional deficits included abolition IL-12 IL-23 production by conventional DC1s...
Abstract To achieve immune and microbial homeostasis during adulthood, the developing system must learn to identify which microbes tolerate defend against. How such ‘immune education’ unfolds remains a major knowledge gap. We address this gap by synthesizing existing literature develop mechanistic mathematical model representing interplay between gut ecology adaptive immunity in early life. Our results indicate that inflammatory tone of microenvironment is mediator information flow from pre-...
Mild or transient dietary restriction (DR) improves many aspects of health and aging. Emerging evidence from us others has demonstrated that DR also optimizes the development quality immune responses. However, factors mechanisms involved remain to be elucidated. Here, we propose DR-induced optimization immunological memory requires a complex cascade events involving T cells, intestinal microbiota, myeloid cells. Our findings suggest enhances ability cells recruit activate in context...
Protein overload activates proximal tubule epithelial cells (PTECs) to release chemokines. Bone morphogenetic protein-7 (BMP-7) reduces infiltrating and tissue damage in acute chronic renal injuries. The present study examines the inhibitory effect related molecular mechanism of BMP-7 on chemokine adhesion molecule synthesis by PTECs activated with human serum albumin (HSA). expression profiles chemokines molecules cultured were screened PCR array. Expression CXCL1, CXCL2 vascular cell...
The somatosensory nervous system surveils external stimuli at barrier tissues, regulating innate immune cells under infection and inflammation. roles of sensory neurons in controlling the adaptive system, more specifically immunity to microbiota, however, remain elusive. Here, we identified a novel mechanism for direct neuroimmune communication between commensal-specific T lymphocytes mediated by neuropeptide Calcitonin Gene-Related Peptide (CGRP) skin. Intravital imaging revealed that are...