Lars Rogge
A5044143952- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Psoriasis: Treatment and Pathogenesis
- Spondyloarthritis Studies and Treatments
- Immunotherapy and Immune Responses
- Autoimmune and Inflammatory Disorders Research
- Cytokine Signaling Pathways and Interactions
- Immunodeficiency and Autoimmune Disorders
- IL-33, ST2, and ILC Pathways
- Hematopoietic Stem Cell Transplantation
- Diabetes and associated disorders
- Single-cell and spatial transcriptomics
- CAR-T cell therapy research
- Cell Adhesion Molecules Research
- Immune Response and Inflammation
- Rheumatoid Arthritis Research and Therapies
- Monoclonal and Polyclonal Antibodies Research
- Inflammatory Bowel Disease
- Cancer Immunotherapy and Biomarkers
- Dermatology and Skin Diseases
- Genomics and Chromatin Dynamics
- Asthma and respiratory diseases
- Eosinophilic Esophagitis
- Diabetes Management and Research
- RNA Interference and Gene Delivery
Institut Pasteur
2016-2025
Université Paris Cité
2022-2025
Roche (France)
2022
Hôpital Cochin
2019-2022
Assistance Publique – Hôpitaux de Paris
2019-2022
Centre National de la Recherche Scientifique
2008-2016
Inserm
2013-2015
Roche (Switzerland)
1999-2001
Roche (Italy)
1995-2000
Stanford University
1992-1995
Interleukin-12 (IL-12), a heterodimeric cytokine produced by activated monocytes and dendritic cells, plays crucial role in regulating interferon (IFN)-γ production the generation of IFN–γ–producing T helper 1 (Th1) cells. Here we show that IL-12 receptor (IL12R) β2 subunit, recently cloned binding signal transducing component IL-12R, is expressed on human Th1 but not Th2 clones induced during differentiation naive cells along pathway. type I II interferons induce expression IL-12R chain...
Group 2 innate lymphoid cells (ILC2) include IL-5– and IL-13–producing CRTh2+CD127+ that are implicated in early protective immunity at mucosal surfaces. Whereas functional plasticity has been demonstrated for both human mouse ILC3 subsets can reversibly give rise to IFN-γ–producing ILC1, of or ILC2 not shown. Here, we analyze the phenotypic heterogeneity peripheral blood ILC2. Although CRTh2+ differentially express CD117 (c-kit receptor), some surface phenotypes unstable be modulated vitro....
Significance Identifying the drivers of interindividual diversity human immune system is crucial to understand their consequences on immune-mediated diseases. By examining transcriptional responses 1,000 individuals various microbial challenges, we show that age and sex influence expression many immune-related genes, but effects are overall moderate, whereas genetic factors affect a smaller gene set with stronger effect. We identify numerous variants variation infection, which associated...
Abstract Individuals differ widely in their immune responses, with age, sex and genetic factors having major roles this inherent variability 1–6 . However, the variables that drive such differences cytokine secretion—a crucial component of host response to challenges—remain poorly defined. Here we investigated 136 identified smoking, cytomegalovirus latent infection body mass index as contributors response, effects comparable magnitudes genetics. We find smoking influences both innate...
Abstract Type I IFNs (IFN-α/β), in addition to IL-12, have been shown play an important role the differentiation of human, but not mouse, Th cells. We show here that IFN-α/β act directly on human T cells drive Th1 development, bypassing need for IL-12-induced signaling, whereas IFN-α cannot substitute IL-12 mouse development. The molecular basis this species specificity is activate Stat4 differentiating Unlike which acts only cells, can Th1, also Th2 However, restimulation lines and clones...
Abstract Induced pluripotent stem cells (iPSCs) have considerably impacted human developmental biology and regenerative medicine, notably because they circumvent the use of embryonic origin offer potential to generate patient-specific cells. However, conventional reprogramming protocols produce developmentally advanced, or primed, iPSCs (hiPSCs), restricting their post-implantation development modeling. Hence, there is a need for hiPSCs resembling preimplantation naive epiblast. Here, we...
Despite improvement in clinical management, allogeneic hematopoietic stem cell transplantation (HSCT) is still hampered by high morbidity and mortality rates, mainly due to graft versus host disease (GvHD). Recently, it has been demonstrated that the immune response might be influenced external factors such as tissues microenvironment or microbiota. Here we used throughput metabolomics analyze two cohorts of genotypically HLA-identical related recipient donor pairs. Metabolomic profiles...
Systems approaches for the study of immune signaling pathways have been traditionally based on purified cells or cultured lines. However, in vivo responses involve coordinated action multiple cell types, which interact to establish an inflammatory microenvironment. We employed standardized whole-blood stimulation systems test hypothesis that Toll-like receptor ligands whole microbes can be defined by transcriptional signatures key cytokines. found 44 genes, identified using Support Vector...
Epigenetic changes are required for normal development, yet the nature and respective contribution of factors that drive epigenetic variation in humans remain to be fully characterized. Here, we assessed how blood DNA methylome 884 adults is affected by sequence variation, age, sex 139 relating life habits immunity. Furthermore, investigated whether these effects mediated or not cellular composition, measured deep immunophenotyping. We show methylation differs substantially between naïve...
Nuclear factor I (NFI) was purified to homogeneity from porcine liver by DNA-affinity chromatography and displays a single band with molecular weight of 36 kDa in SDS-polyacrylamide gels. The protein used determine absolute equilibrium binding constants gel retardation techniques for variety DNA fragments genuine or mutated NFI sites number derived various eukaryotic promoters carrying the CCAAT-box as half-site binding. We present model which allows prediction functional significance...
CD1d-reactive invariant NKT (iNKT) cells have been implicated in a number of experimental models human pathologies. Given the scope their immunoregulatory activities mediated through distinct cytokine patterns, it has proposed that this functional diversity originates from iNKT subpopulations. In study, we report CD161(+) are intrinsically endowed with capacity to generate IL-17, but require TGF-β, IL-1β, and IL-23 carry out potential. IL-17-producing already present cord blood but, contrast...
The Milieu Intérieur Consortium has established a 1000-person healthy population-based study (stratified according to sex and age), creating an unparalleled opportunity for assessing the determinants of human immunologic variance. Herein, we define criteria utilized participant enrollment, highlight key data that were collected correlative studies. In this report, analyzed biological correlates sex, age, smoking-habits, metabolic score CMV infection. We characterized identified unique risk...
Abstract Great attention has been placed on the possibility of distinguishing Th1 from Th2 cells basis differential expression surface receptors. We have recently shown that IL-12Rβ2 chain in and cells, as measured at mRNA level, accounts for an important regulatory mechanism differentiation two cell subsets. In this study, we identify IL-12R protein level. generated anti-IL-12Rβ2-specific mAb analyzed polarized Th populations vitro T derived patients with Th1- or Th2-mediated inflammatory...
Integrin adhesion receptors can act as signaling that transmit information from the extracellular environment to interior of cell, affecting many fundamental cellular processes, such cell motility, proliferation, differentiation, and survival. depends on formation organized sub-membrane complexes comprise cytoskeletal, adapter, molecules. The identification molecules interact with cytoplasmic domain integrins has been focus research aimed elucidating mechanistic basis integrin signal...