A5049742959- Immune Cell Function and Interaction
- Metabolism, Diabetes, and Cancer
- Viral-associated cancers and disorders
- Hematopoietic Stem Cell Transplantation
- Lymphoma Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- Pancreatic function and diabetes
- Glycosylation and Glycoproteins Research
- Nitric Oxide and Endothelin Effects
- Cytomegalovirus and herpesvirus research
- Protein purification and stability
- Pharmacological Effects and Toxicity Studies
- HIV/AIDS Research and Interventions
- T-cell and B-cell Immunology
- HIV Research and Treatment
- Neuroscience of respiration and sleep
- Advanced Neuroimaging Techniques and Applications
- Obstructive Sleep Apnea Research
- Cancer-related Molecular Pathways
- Epilepsy research and treatment
- Barrier Structure and Function Studies
- Drug Transport and Resistance Mechanisms
- Multiple Myeloma Research and Treatments
- Immune cells in cancer
- CAR-T cell therapy research
Inserm
2017-2023
Université de Montpellier
2017-2023
Institute for Regenerative Medicine & Biotherapy
2020-2022
Établissement Français du Sang
2020
Centre National de la Recherche Scientifique
2017-2018
Institut de Génomique Fonctionnelle
2017
Leukemic cells proliferate faster than non-transformed counterparts. This requires them to change their metabolism adapt high growth. can stress and facilitate recognition by immune such as cytotoxic lymphocytes, which express the activating receptor Natural Killer G2-D (NKG2D). The tumor suppressor gene p53 regulates cell metabolism, but its role in expression of metabolism-induced ligands, subsequent is unknown. We show here that dichloroacetate (DCA), induces oxidative phosphorylation...
Abstract Solid tumor cells have an altered metabolism that can protect them from cytotoxic lymphocytes. The anti-diabetic drug metformin modifies cell and several clinical trials are testing its effectiveness for the treatment of solid cancers. use in hematologic cancers has received much less attention, although allogeneic lymphocytes very effective against these tumors. We show here induces expression Natural Killer G2-D (NKG2D) ligands (NKG2DL) intercellular adhesion molecule-1 (ICAM-1),...
In this study we evaluated the potential of expanded NK cells (eNKs) from two sources combined with mAbs daratumumab and pembrolizumab to target primary multiple myeloma (MM) ex vivo. order ascertain best source cells, activated peripheral blood (PB) healthy adult donors umbilical cord (UCB). The resulting (eNK) express CD16, necessary for carrying out antibody-dependent cellular cytotoxicity (ADCC). Cytotoxicity assays were performed on bone marrow aspirates 18 MM patients 4 monoclonal...
Summary Objective Available evidence points to a role of cytochrome P450 (Cyp) drug biotransformation enzymes in central nervous system diseases, including epilepsy. Deviations pharmacokinetic profiles may impact therapeutic outcomes. Here, we ask whether spontaneous recurrent seizure ( SRS ) activity is sufficient modulate the expression major Cyp liver and brain. Methods Unilateral intrahippocampal (IH) kainic acid KA injections were used elicit nonconvulsive status epilepticus SE ),...
Static apnea provides a unique model that combines transient hypertension, hypercapnia, and severe hypoxemia. With durations exceeding 5 min, the purpose of present study was to determine how affects cerebral free-radical formation corresponding implications for brain structure function. Measurements were obtained before following maximal in 14 divers with transcerebral exchange kinetics, measured as product global blood flow (duplex ultrasound) radial arterial internal jugular venous...
Background Viral load monitoring and early Epstein-Barr virus (EBV) DNA detection are essential in routine laboratory testing, especially preemptive management of Post-transplant Lymphoproliferative Disorder. Targeting the repetitive BamHI-W sequence was shown to increase sensitivity EBV quantification, but variability reiterations suggested be a source quantification bias. We aimed assess extent associated with PCR its impact on using 1st WHO international standard, strains clinical...
CD20 monoclonal antibodies (mAbs) eliminate B cells in several clinical contexts. At least two of these Abs, obinutuzumab (OBI) and rituximab (RTX), induce quick elimination targets put cancer patients at risk tumor lysis syndrome (TLS) within 12-24 h the first dose. The mechanisms killing can require recruiting effector from patient's immune system, but they direct as well. This be more rapid than cellular effectors and/or complement. We showed here that OBI RTX (<1 h) high (up to 60% for...
Abstract Background Immune control of Epstein-Barr virus (EBV) infection is impaired in individuals with HIV. We explored maternal factors associated EBV acquisition HIV-exposed uninfected (HEU) infants and the relationship between serious adverse events (SAEs) during first year life. Methods 201 HEU from Uganda enrolled ANRS 12174 trial were tested for antiviral capsid antigen (anti-VCA) antibodies at week 50. Date was estimated by testing DNA weeks 1, 6, 14, 26, 38, 50 postpartum on dried...
Solid tumor cells have an altered metabolism that can protect them from cytotoxic lymphocytes. The antidiabetic drug metformin modifies cell and several clinical trials are testing its effectiveness for the treatment of solid cancers. use in hematologic cancers has received much less attention, although allogeneic lymphocytes very effective against these tumors. We show here induces expression Natural Killer G2-D (NKG2D) ligands (NKG2DL) intercellular adhesion molecule-1 (ICAM-1), a ligand...
Abstract Solid tumor cells have an altered metabolism that can protect them from cytotoxic lymphocytes. The antidiabetic drug metformin modifies cell and several clinical trials are testing its effectiveness for the treatment of solid cancers. use in hematologic cancers has received much less attention, although allogeneic lymphocytes very effective against these tumors. We show here induces expression Natural Killer G2-D (NKG2D) ligands (NKG2DL) intercellular adhesion molecule-1 (ICAM-1), a...
Abstract Solid tumor cells have an altered metabolism that can protect them from cytotoxic lymphocytes. The antidiabetic drug metformin modifies cell and several clinical trials are testing its effectiveness for the treatment of solid cancers. use in hematologic cancers has received much less attention, although allogeneic lymphocytes very effective against these tumors. We show here induces expression Natural Killer G2-D (NKG2D) ligands (NKG2DL) intercellular adhesion molecule-1 (ICAM-1), a...