A5107498298- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Ubiquitin and proteasome pathways
- Circular RNAs in diseases
- Cancer-related Molecular Pathways
- Immune cells in cancer
- Hematopoietic Stem Cell Transplantation
- Cancer Mechanisms and Therapy
- interferon and immune responses
- Medicinal Plant Pharmacodynamics Research
- Immunotherapy and Immune Responses
- Multiple Myeloma Research and Treatments
- Microtubule and mitosis dynamics
- RNA Interference and Gene Delivery
- Chronic Lymphocytic Leukemia Research
The University of Texas MD Anderson Cancer Center
2009-2024
Instituto de Investigación Sanitaria Aragón
2020-2023
Universidad de Zaragoza
2020-2023
Abstract Purpose: The incidence of regulatory T cells (Treg) in intrinsic central nervous system malignancies is unknown. Immunotherapeutic approaches that inhibit the Treg population may be limited to a subset patients with gliomas. Our hypothesis only most malignant gliomas have prominent glioma-infiltrating contributes immunosuppressive biology and presence Tregs negative prognostic variable. Experimental Design: We measured 135 glial tumors (including all pathologic types) glioma...
Abstract Purpose: The signal transducer and activator of transcription 3 (STAT3) is frequently overexpressed in most cancers, propagates tumorigenesis, a key regulator immune suppression cancer patients. We sought to determine the incidence phosphorylated STAT3 (p-STAT3) expression malignant gliomas different pathologic types, whether p-STAT3 negative prognostic factor, influences inflammatory response within gliomas. Methods: Using immunohistochemical analysis, we measured 129 patients with...
In this study we evaluated the potential of expanded NK cells (eNKs) from two sources combined with mAbs daratumumab and pembrolizumab to target primary multiple myeloma (MM) ex vivo. order ascertain best source cells, activated peripheral blood (PB) healthy adult donors umbilical cord (UCB). The resulting (eNK) express CD16, necessary for carrying out antibody-dependent cellular cytotoxicity (ADCC). Cytotoxicity assays were performed on bone marrow aspirates 18 MM patients 4 monoclonal...
Melanoma is a common and deadly tumor that upon metastasis to the central nervous system has median survival duration of <6 months. Activation signal transducer activator transcription 3 (STAT3) been identified as key mediator drives fundamental components melanoma malignancy, including immune suppression in patients. We hypothesized WP1193, novel inhibitor STAT3 signaling, would enhance antitumor activity IFN-alpha against metastatic melanoma.Combinational therapy blockade agents with was...
Adoptive transfer of allogeneic natural killer (NK) cells is becoming a credible immunotherapy for hematological malignancies. In the present work, using an optimized expansion/activation protocol human NK cells, we generate expanded (eNK) with increased expression CD56 and NKp44, while maintaining that CD16. These eNK exerted significant cytotoxicity against from 34 B-CLL patients, only 1 sample exhibiting resistance. This sporadic resistance did not correlate match between KIR ligands...
INTRODUCTION: The incidence of the immune inhibitor regulatory T cells (Tregs), activated by STAT-3, within intrinsic central nervous system malignancies is unknown. Our hypothesis was that most malignant gliomas have a prominent glioma infiltrating Treg population contributes to immunosuppressive biology and prognosis patients generation Tregs can be blocked STAT-3 (WP1066), allowing for immunological clearance intracerebral tumors. METHODS: We measured in 135 glial tumors on microarray...
Abstract Background The signal transducer and activator of transcription 3 (STAT-3) is frequently overexpressed in cancer cells, propagates tumorigenesis, a key regulator immune suppression patients. presence phosphorylated STAT-3 (p-STAT-3) the tumor can induce p-STAT-3 tumor-associated cells that return to circulatory system. We hypothesized number peripheral blood mononuclear (PBMCs) displaying would be increased glioma patients, which correlate with extent tumor-expressed p-STAT-3,...
Therapies based on allogenic Natural Killer (NK) cells are becoming increasingly relevant, and our laboratory has produced expanded activated NK (eNK) that highly cytotoxic against several hematological cancers when used alone or in combination with currently approved therapeutic monoclonal antibodies. In order to produce eNK cells, healthy human donor undergo a 20-day expansion protocol IL-2, IL-15 Epstein-Barr virus (EBV)-transformed lymphoblastoid feeder cells. an even more potent...
Abstract Natural Killer (NK) cells have shown great promise as a viable cell-based cancer immunotherapy. We developed protocol that produces expanded and highly activated NK (eNK) from healthy human donors been to be effective alone in combination with monoclonal antibodies variety of hematological malignancies. The eNK showed dramatic increase cytolytic capacity after their expansion activation using IL-2, IL-15, 721.221 feeder cells. In order elucidate the underlying mechanisms behind...