A5006220266- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- IL-33, ST2, and ILC Pathways
- Cytokine Signaling Pathways and Interactions
- Tuberculosis Research and Epidemiology
- Immune Response and Inflammation
- Mycobacterium research and diagnosis
- Immunodeficiency and Autoimmune Disorders
- Psoriasis: Treatment and Pathogenesis
- Diabetes and associated disorders
- Reproductive System and Pregnancy
- Dermatology and Skin Diseases
- interferon and immune responses
- CAR-T cell therapy research
- Immune responses and vaccinations
- Antimicrobial Peptides and Activities
- Cancer Immunotherapy and Biomarkers
- Whipple's Disease and Interleukins
- Eosinophilic Esophagitis
- Monoclonal and Polyclonal Antibodies Research
- Signaling Pathways in Disease
- Inflammasome and immune disorders
- Oral microbiology and periodontitis research
- TGF-β signaling in diseases
National Institutes of Health
2013-2024
National Cancer Institute
2014-2024
Center for Cancer Research
2017-2024
Harvard University
2005-2016
University of Pittsburgh
2001-2005
Periodontitis is one of the most common human inflammatory diseases, yet mechanisms that drive immunopathology and could be therapeutically targeted are not well defined. Here, we demonstrate an expansion resident memory T helper 17 (TH17) cells in periodontitis. Phenocopying humans, TH17 expanded murine experimental periodontitis through local proliferation. Unlike homeostatic oral cells, which accumulate a commensal-independent interleukin-6 (IL-6)-dependent manner,...
The speed of impulse transmission is critical for optimal neural circuit function, but it unclear how the appropriate conduction velocity established in individual axons. influenced by thickness myelin sheath and morphology electrogenic nodes Ranvier along Here we show that nodal gap length are reversibly altered astrocytes, glial cells contact Ranvier. Thrombin-dependent proteolysis a cell adhesion molecule attaches to axon (neurofascin 155) inhibited vesicular release thrombin protease...
ABSTRACT Comparison of human immunodeficiency virus lentiviral lytic peptide 1 with other host-derived peptides indicates that antimicrobial properties membrane-active are markedly influenced by their cationic, hydrophobic, and amphipathic properties. Many common themes, such as Arg composition the cationic face an helix importance maintaining hydrophobic face, have been deduced from these observations. These studies suggest a structural can be derived de novo using only few strategically...
Abstract The control of acute and chronic Mycobacterium tuberculosis infection is dependent on CD4+ T cells. In a variety systems CD8+ cell effector responses are help. development cell-mediated immune in the absence cells was investigated murine model tuberculosis. vitro vivo, priming mycobacteria-specific unaffected by Infiltration into infected lungs CD4−/− or wild-type mice similar. IFN-γ production lung also comparable, suggesting that emergence IFN-γ-producing independent contrast,...
Abstract A sustained CD4+ Th1-dominated type 1 immune response is required to successfully control Mycobacterium tuberculosis infection. Considerable work has demonstrated that the transcription factor, T-bet, for IFN-γ expression and fundamental generation of immunity in multiple cell types. Mice lacking T-bet are susceptible virulent M. Susceptibility T-bet-deficient mice associated with increased systemic bacterial burden, diminished production, striking accumulation eosinophilic...
Abstract The primary goal of this study was to determine how chronic exposure Ag influences the functionality Mycobacterium tuberculosis-specific T cell responses. frequency IFN-γ-producing effector CD4+ and CD8+ cells dynamically changed during persistent M. tuberculosis infection. used differential functions acute phases immune response, where produced negligible amounts IFN-γ early in infection, but switched cytokine production stage Using limiting dilution analysis, isolated initial...
Abstract IL-23 plays an important role in autoimmune tissue inflammation and induces the generation of not fully characterized effector cells that mediate protection against pathogens. In this paper, we established essential IL-23R host response intracellular was critical for expansion or maintenance γδ double negative (DN) αβ T cells. These were rapidly recruited to site infection produced large amounts IL-17, IFN-γ, TNF-α. Notably, DN transferred into L. monocytogenes-infected RAG2−/− mice...
Abstract Initial events after exposure determine HIV-1 disease progression, underscoring a critical need to understand host mechanisms that interfere with initial viral replication. Although associated chronic control, it is not known whether interleukin-21 (IL-21) contributes early immunity. Here we take advantage of tractable primary human lymphoid organ aggregate cultures show IL-21 directly suppresses replication, and identify microRNA-29 (miR-29) as an antiviral factor induced by in CD4...
The cross-talk between the microbiota and immune system plays a fundamental role in control of host physiology. However, tissue-specific factors controlling this dialogue remain poorly understood. Here we demonstrate that T cell responses to commensal colonization are associated with development organized cellular clusters within skin epithelium. These lymphocyte surrounded by keratinocytes expressing discrete program antigen presentation antimicrobial defense. Notably, IL-22–mediated...
Multiple sclerosis (MS) is a disabling demyelinating autoimmune disorder of the central nervous system (CNS) which driven by IL-23- and IL-1β-induced autoreactive Th17 cells that traffic to CNS secrete proinflammatory cytokines. pathogenicity in MS has been correlated with dysregulation microRNA (miRNA) expression, specific miRNAs have shown promote pathogenic phenotype. In present study, we demonstrate, using animal model MS, experimental encephalomyelitis (EAE), let-7 confer protection...
Mice lacking the large zinc finger protein Schnurri-3 (Shn3) display increased bone mass, in part, attributable to augmented osteoblastic formation. Here, we show that addition regulating formation, Shn3 indirectly controls resorption by osteoclasts vivo. Although plays no cell-intrinsic role osteoclasts, Shn3-deficient animals decreased serum markers of turnover. Mesenchymal cells are defective promoting osteoclastogenesis response selective stimuli, likely reduced expression key...
Significance Multiple sclerosis (MS) is an immune-mediated disease that impacts the central nervous system. A murine model of MS, experimental autoimmune encephalomyelitis (EAE), used to determine mechanism MS pathogenesis. STAT5 a transcription factor plays critical role in mediating cellular responses following cytokine stimulation. Activated proteins undergo functional dimerization and tetramerization. This study demonstrates tetramers promote pathogenesis EAE. facilitate interactions...