A5068456972- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Blood groups and transfusion
- Pharmacological Effects and Toxicity Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Folate and B Vitamins Research
- T-cell and B-cell Immunology
- Pharmacogenetics and Drug Metabolism
- Advanced Malware Detection Techniques
- Immune Cell Function and Interaction
- Food Security and Health in Diverse Populations
- RNA modifications and cancer
- Cardiac electrophysiology and arrhythmias
- Epigenetics and DNA Methylation
- Adipose Tissue and Metabolism
- Erythropoietin and Anemia Treatment
- Prenatal Screening and Diagnostics
- Bone and Joint Diseases
- Cardiac Ischemia and Reperfusion
- Cytokine Signaling Pathways and Interactions
- Erythrocyte Function and Pathophysiology
- Diabetes Treatment and Management
- RNA Research and Splicing
- Hormonal Regulation and Hypertension
- Epilepsy research and treatment
University of Illinois Chicago
2016-2025
Guangzhou Medical University
2023-2024
Wuhan University
2023-2024
Guangzhou Women and Children Medical Center
2024
University of Illinois Urbana-Champaign
2011-2023
Shantou University
2022
Shantou University Medical College
2022
Pharmac
2021
Yantaishan Hospital
2021
Busan Medical Center
2019
We aimed to identify predictors of outcomes and survival in patients living 4 major metropolitan areas who had sickle cell disease (SCD) COVID-19 inform best approaches prevention care. Data were collected at baseline during the clinical course SCD diagnosed with four epicenters. Patients followed up posthospital discharge for 3 months. Of sixty-six COVID-19, fifty (75%) required hospitalization, seven died (10.6%). preexisting kidney (chronic disease) more likely be hospitalized. The most...
The molecular requirements for invariant Valpha14-bearing natural killer T cells (iNKT) in the thymus are poorly understood. A minute population of approximately 500 newly selected CD69(+)CD24(+) stage 0 (ST0) iNKT gives rise to 100 times more CD44(neg/lo)CD24(-) 1 (ST1) cells, which then generate similar frequencies CD44(hi)CD24(-) 2 (ST2) and mature cells. Although increased number ST1 compared with ST0 indicates initiation a proliferation wave very early stages cell development, details...
IL-15 and NKG2D promote autoimmunity celiac disease by arming cytotoxic T lymphocytes (CTLs) to cause tissue destruction. However, the downstream signaling events underlying these functional properties remain unclear. Here, we identify cytosolic phospholipase A2 (cPLA2) as a central molecule in NKG2D-mediated cytolysis CTLs. Furthermore, report that induces, upon recognition of MIC+ target cells, release arachidonic acid (AA) CTLs inflammation association with killing. Interestingly, IL-15,...
The authors provide a systematic security analysis on the sharing methods of three major cloud storage and synchronization services: Dropbox, Google Drive, Microsoft SkyDrive. They show that all services have weaknesses may result in data leakage without users' awareness.
Sickle cell disease (SCD) patients are at a four- to 100-fold increased risk for thrombosis compared with the general population, although mechanisms and factors not clear. We investigated incidence predictors in retrospective, longitudinal cohort of 1193 pediatric adult SCD treated our institution between January 2008 December 2017. diagnosis thrombotic complications were identified using International Classification Diseases coding verified through medical chart review. Clinical laboratory...
Opioid analgesics are commonly used to treat vaso-occlusive pain episodes in sickle cell disease (SCD), but comprehensive evidence characterizing opioid use this patient population is limited. Our objective was characterize patterns among SCD patients using a large nationwide database.A large, US medical claims database utilized identify cohort of 3882 patients, and characteristics were analyzed. Clinical variables including age, gender, medication use, health care utilization, history...
Abnormal hemostasis in cancer patients has prev iously been studied. The primary objective of the present study was to evaluate association between preoperative markers and clinicopathological parameters, identify a marker affecting survival following curative resection for colorectal cancer. A total 170 who underwent surgery carcinoma were evaluated. Preoperative coagulation tests included platelet, prothrombin time (PT), activated partial thromboplastin (aPTT), fibrinogen, D-dimer...
Abstract The BCR serves as both signal transducer and Ag transporter. Binding of Ags to the induces signaling cascades processing presentation, two essential cellular events for B cell activation. BCR-initiated increases BCR-mediated Ag-processing efficiency by increasing rate specificity transport. Previous studies showed a critical role actin cytoskeleton in these processes. In this study, we found that actin-binding protein 1 (Abp1/HIP-55/SH3P7) functioned an adaptor protein, coupling...
Touchscreen mobile devices are becoming commodities as the wide adoption of pervasive computing. These allow users to access various services at anytime and anywhere. In order prevent unauthorized these services, passwords have been pervasively used in user authentication. However, password-based authentication has intrinsic weakness password leakage. This threat could be more serious on devices, widely public places.
One hundred and seventy seven acetone extracts of lichen 258 ethyl acetate cultured lichen-forming fungi (LFF) were screened for antimicrobial activity against Staphylococcus aureus Enterococcus faecium using a disk diffusion method. Divaricatic acid was isolated from Evernia mesomorpha identified by LC-MS, ¹H-, 13C- DEPT-NMR. Purified divaricatic effective Gram + bacteria, such as Bacillus subtilis, epidermidis, Streptococcus mutans, faecium, with the minimum inhibitory concentration (MIC)...
Pain, the hallmark complication of sickle cell disease (SCD), is largely managed with opioid analgesics in United States, but comprehensive data regarding long-term use opioids this patient population lacking. The pain medication prescription records from a cohort 203 SCD patients were analyzed. Twenty-five percent not prescribed medications while 47% took only short-acting opioids, 1% long-acting and 27% combination opioids. median (interquartile range) daily dose was 6.1 mg (1.7-26.3 mg)...
Engagement of the T-cell receptor (TCR) triggers a series signaling events that lead to activation T cells. HIP-55 (SH3P7 or mAbp1), an actin-binding adaptor protein, interacts with and is tyrosine phosphorylated by ZAP-70, which crucial proximal protein kinase for TCR signaling. important JNK HPK1 induced In this study, we report generation characterization knockout mice. We found mice were viable fertile but showed decreased body weight increased occurrence death within first 4 weeks after...
HIP-55 (hematopoietic progenitor kinase 1 (HPK1)-interacting protein of 55 kDa, also called SH3P7 and mAbp1) is a novel SH3 domain-containing protein. binds to actin filaments both in vitro vivo. activates HPK1 c-Jun N-terminal (JNK), which are two important lymphocyte signaling molecules. Until now, the regulation function T cell receptor (TCR) were unknown. We found that was recruited glycolipid-enriched microdomains upon TCR stimulation, indicates regulated by signaling. interacted with...
CUG-BP and ETR-3 like factor (CELF) proteins are regulators of pre-mRNA alternative splicing. We created a series truncation mutants to identify the regions CELF that required activate repress splicing different exons. This analysis was performed in parallel on two proteins, (CUG-BP2, NAPOR, BRUNOL3) CELF4 (BRUNOL4). identified 20-residue region for repression or activation, contrast ETR-3, which residues more disperse. For both CELF4, distinct were exons, while an additional third exon...