A5019988055- Cancer Research and Treatments
- Melanoma and MAPK Pathways
- Lung Cancer Treatments and Mutations
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Cell death mechanisms and regulation
- HER2/EGFR in Cancer Research
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Microtubule and mitosis dynamics
- Protein Tyrosine Phosphatases
- Cancer, Hypoxia, and Metabolism
- Cancer Mechanisms and Therapy
- Bladder and Urothelial Cancer Treatments
- NF-κB Signaling Pathways
- Ubiquitin and proteasome pathways
- Telomeres, Telomerase, and Senescence
- Cancer-related Molecular Pathways
- Mechanisms of cancer metastasis
- Cancer, Lipids, and Metabolism
- Genomics, phytochemicals, and oxidative stress
- RNA modifications and cancer
- PI3K/AKT/mTOR signaling in cancer
- Colorectal Cancer Treatments and Studies
- DNA and Nucleic Acid Chemistry
Renji Hospital
2021-2025
Shanghai Jiao Tong University
2021-2025
National Health Research Institutes
2012-2025
Southern Taiwan University of Science and Technology
2025
Laboratoire de Synthèse Organique
2025
Affiliated Hospital of Southwest Medical University
2023-2025
Institute of Molecular Medicine
2025
Soochow University
2024
Panyu District Central Hospital
2021-2024
Chongqing Medical University
2022-2024
c-Jun N-terminal kinases (JNKs) participate in cellular responses to mitogenic stimuli, environmental stresses, and apoptotic agents. The mechanisms by which JNK integrates with other signaling pathways regulates the diverse events are unclear. We found JNK, but not p38-mitogen-activated protein kinase (MAPK) or extracellular signal-regulated 2, be persistently activated apoptosis induced γ radiation, UV-C, anti-Fas treatment. Direct correlation was between activation UV-C radiation;...
Abstract Purpose: Epidermal growth factor receptor (EGFR) mutations related to gefitinib responsiveness in non–small cell lung cancer have been found recently. Detection of EGFR has become an important issue for therapeutic decision-making cancer. Experimental Design: Mutational analysis the kinase domain coding sequence was done on 101 fresh frozen tumor tissues from patients without prior treatment and 16 paraffin-embedded treated with gefitinib. phosphorylated by immunoblot also tissues....
Isothiocyanates have strong chemopreventive properties against many carcinogen-induced cancers in experimental animal models. Here, we report that phenylmethyl isocyacyanate (PMITC) and phenylethyl isothio- cyanate (PEITC) induced sustained c-Jun N-terminal kinase (JNK) activation a dose-dependent manner. The JNK caused by isothiocyanates was associated with apoptosis induction various cell types. An inhibitor of the caspase/interleukin-1β-converting enzyme blocked isothiocyanate-induced...
BackgroundRecently Echinoderm microtubule-associated protein-like 4- anaplastic lymphoma kinase (EML4-ALK) fusion gene has become an important biomarker for ALK tyrosine inhibitor (crizotinib) treatment in NSCLC. However, the best detection method and significance of EML4-ALK variant types remain uncertain. MethodsReverse transcriptase-polymerase chain reaction (RT-PCR), fluorescence Situ hybridization (FISH) Immunohistochemical (IHC) stain were performed on tumor tissues 312 NSCLC patients...
HTS hit 7 was modified through hybrid design strategy to introduce a chiral side chain followed by introduction of Michael acceptor group obtain potent EGFR kinase inhibitors 11 and 19. Both 19 showed over 3 orders magnitude enhanced HCC827 antiproliferative activity compared also inhibited gefitinib-resistant double mutant (DM, T790M/L858R) at nanomolar concentration. Moreover, treatment with shrinked tumor in nude mice xenograft model.
In western countries, the Kirsten ras oncogene homolog gene (KRAS) mutation rate is high in patients with nonsmall cell lung cancer (NSCLC), especially those adenocarcinoma (30%-50%), but epidermal growth factor receptor (EGFR) very low (3%-8%). addition, KRAS mutations reportedly were associated EGFR tyrosine kinase inhibitor (EGFR-TKI) resistance. Taiwan, rates EGFR-TKI response NSCLC have been reported; however, data are limited and not correlated TKI response.KRAS analysis was performed...
Epidermal growth factor receptor (EGFR) gene mutations are strongly associated with lung adenocarcinoma and favorable response to EGFR tyrosine kinase inhibitor. The mutated proteins (EGFRs) hyper-phosphorylated refractory down-regulation. To address the discrepancy between hyper-phosphorylation lack of down-regulation mutant EGFRs, we have examined expression negative regulators in non-small cell cancer (NSCLC) lines. We found that NSCLC lines expressing EGFRs often had low various for...
Overexpression of the serine/threonine kinase GLK/MAP4K3 in human lung cancer is associated with poor prognosis and recurrence, however, role GLK recurrence remains unclear. Here, we report that transgenic promotes tumor metastasis cell migration through scaffold protein IQ motif-containing GTPase-activating 1(IQGAP1). mice displayed enhanced distant metastasis. IQGAP1 was identified as a GLK-interacting protein; two proline-rich regions WW domain mediated this interaction. colocalized at...
The antibacterial activity of copper (Cu)-alloy biomaterials has shown a great potential in clinical application. Here, we evaluated the osteogenesis and effects Ti6Al4V-6.5wt%Cu alloy an vivo model infected bone defects determine their responsible proteins pathways using proteomics.After were filled with Ti6Al4V implants for 6 week, tissue samples around harvested radiographic, micro-CT, histological, bone-related gene expression analyses. An iTRAQ-based protein...
ABSTRACT Aims Current metabolic syndrome (mets) criteria often lack consideration for age and gender differences. This study introduces the mets‐Z score, a novel tool designed to enhance mets assessment improve long‐term outcome predictions. Materials Methods The score was developed using principal component analysis (PCA) weight five indicators—waist circumference, blood glucose, pressure, high‐density lipoprotein (HDL) cholesterol, triglycerides—by age. Data from 188,739 Taiwan Biobank...
The accurate assessment of pupillary light reflex (PLR) is essential for monitoring critically ill patients, particularly those with traumatic brain injury or stroke and in postoperative care. Smartphone-based pupillometers represent a potentially cost-effective solution addressing this need. We developed smartphone pupillometer application (app) evaluated its effectiveness against the penlight test quantitative pupillometry. This study included 50 volunteers aged >20 years excluded...
The recognition and binding via receptor-ligand interactions on cell membranes often weaken in complex environments, such as whole blood samples from cancer patients, making disease diagnosis treatment evaluation unfavorable. Constructing multivalent ligands with sufficient fluid stability environments remains a challenge. Herein, we develop tetrahedral DNA framework (TDF) ensembled aptamers (TEAn, n = 1-3) programmable size, enabling efficient capture of circulating tumor cells (CTCs)...
Abstract The recognition and binding via receptor‐ligand interactions on cell membranes often weaken in complex environments, such as whole blood samples from cancer patients, making disease diagnosis treatment evaluation unfavorable. Constructing multivalent ligands with sufficient fluid stability environments remains a challenge. Herein, we develop tetrahedral DNA framework (TDF) ensembled aptamers (TEA n , = 1–3) programmable size, enabling efficient capture of circulating tumor cells...