Xulei Tang
A5038747718- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Health and Risk Factors
- Liver Disease Diagnosis and Treatment
- Thyroid Disorders and Treatments
- Nutritional Studies and Diet
- Metabolism, Diabetes, and Cancer
- Chronic Kidney Disease and Diabetes
- Birth, Development, and Health
- Vitamin D Research Studies
- Blood Pressure and Hypertension Studies
- Diabetes Treatment and Management
- Diet and metabolism studies
- Thyroid Cancer Diagnosis and Treatment
- Bone Metabolism and Diseases
- Diet, Metabolism, and Disease
- Bone health and osteoporosis research
- Obesity, Physical Activity, Diet
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer, Lipids, and Metabolism
- Cardiovascular Disease and Adiposity
- Lipoproteins and Cardiovascular Health
- Sleep and related disorders
- Cardiovascular Health and Disease Prevention
- Diabetes Management and Education
- Growth Hormone and Insulin-like Growth Factors
Lanzhou University
2016-2025
First Hospital of Lanzhou University
2016-2025
Hunan Children's Hospital
2025
Central South University
2025
Meteorological Bureau of Shenzhen Municipality
2024
Lanzhou University Second Hospital
2024
Wuyi University
2024
Institute of Modern Physics
2017
Chinese Academy of Sciences
2017
Shanghai Clinical Research Center
2016
Abstract Objective To assess the prevalence of diabetes and its risk factors. Design Population based, cross sectional study. Setting 31 provinces in mainland China with nationally representative data from 2015 to 2017. Participants 75 880 participants aged 18 older—a sample Chinese population. Main outcome measures Prevalence among adults living China, by sex, regions, ethnic groups, estimated 2018 American Diabetes Association (ADA) World Health Organization diagnostic criteria....
Background: Mandatory universal salt iodization (USI) has been implemented in China for 20 years. Although iodine deficiency disorders are effectively controlled, the risk of excess have debated. Methods: A nationally representative cross-sectional study with 78,470 enrolled participants, aged 18 years or older, from all 31 provincial regions mainland was performed. The participants were given a questionnaire and underwent B-mode ultrasonography thyroid. Serum concentrations thyroid...
Abstract Metabolic diseases are the most common and rapidly growing health issues worldwide. The massive population-based human genetics is crucial for precise prevention intervention of metabolic disorders. China Analytics Project (ChinaMAP) based on cohort studies across diverse regions ethnic groups with phenotypic data in China. Here, we describe centralized analysis deep whole genome sequencing genetic bases traits 10,588 individuals from ChinaMAP. frequency spectrum variants,...
OBJECTIVE To investigate whether the association between insulin resistance and cardiovascular disease (CVD) differs by glucose tolerance status. RESEARCH DESIGN AND METHODS We analyzed a nationwide sample of 111,576 adults without CVD at baseline, using data from China Cardiometabolic Disease Cancer Cohort Study. Insulin was estimated sex-specific HOMA (HOMA-IR) quartiles for participants with normal tolerance, prediabetes, or diabetes, separately, 1 SD HOMA-IR overall study participants....
Conscious pigs underwent a sequence of 10 2-min coronary occlusions, each separated by 2 min reperfusion, for three consecutive days (days 1, 2, and 3 stage I). The recovery systolic wall thickening (WTh) after the 10th reperfusion was markedly improved on compared with day indicating that myocardium had become preconditioned against "stunning." d I, again occlusions two 1 II). On II, WTh similar to noted I; however, 1. Blockade adenosine receptors 8-p-sulfophenyl theophylline failed prevent...
To demonstrate whether abnormal glucose metabolism (diabetes and prediabetes) is associated with increased risk for cancer in the Chinese population to identify factors that modify of among individuals metabolism.Between 2011 2012, 259 657 community-dwelling adults, aged 40 years older, were recruited from 25 centers across mainland China participant baseline survey REACTION study, follow-up investigations performed 3, 5, 10 later. Detailed questionnaires about lifestyles, physical...
OBJECTIVE Uncertainty remains regarding the predictive value of various glycemic measures as they relate to risk diabetes and its complications. Using cutoffs recommended by American Diabetes Association’s 2010 criteria, we determined associations fasting plasma glucose (FPG), 2-h postload (2h-PG), HbA1c with outcomes. RESEARCH DESIGN AND METHODS Baseline medical history, FPG, 2h-PG, were obtained from a population-based cohort 193,846 adults aged ≥40 years in China during 2011–2012. A...
OBJECTIVE Comprehensive assessment of serum lipidomic aberrations before type 2 diabetes mellitus (T2DM) onset has remained lacking in Han Chinese. We evaluated changes lipid coregulation antecedent to T2DM and identified novel predictors for individuals with normal glucose regulation (NGR). RESEARCH DESIGN AND METHODS In the discovery study, we tested 667 baseline lipids subjects incident propensity score–matched control (n = 200) from a prospective cohort comprising 3,821 Chinese adults...
Whether optimal cardiovascular health metrics may counteract the risk of events among patients with prediabetes or diabetes is unclear.
Abstract Background Both lipid and glucose abnormalities are associated with hypertension (HTN). However, it is unclear whether the triglyceride-glucose (TyG) index HTN. Therefore aim of this study to investigate association TyG HTN compare discriminative power index, lipid, glycemic parameters for risk in elderly individuals. Methods The present was nested a longitudinal (REACTION) from May 2011 December 2011, which designed demonstrate abnormal metabolism cancer Chinese population. In...
National investigations on age-specific modifiable risk factor profiles for cardiovascular disease (CVD) and mortality are scarce in China, the country that is experiencing a huge cardiometabolic burden exacerbated by population ageing.This nationwide prospective cohort study of 193,846 adults China Cardiometabolic Disease Cancer Cohort Study, 2011-2016. Among 139,925 participants free from CVD at baseline, we examined hazard ratios population-attributable percentages (PAR%s) all-cause...
Although previous studies suggest that amino acids (AAs) and microbiota-related metabolites (MRMs) are associated with type 2 diabetes mellitus (T2DM), the results remain unclear among normoglycemic populations. We test 28 serum AAs 22 MRMs in 3,414 subjects incident matched controls from China Cardiometabolic Disease Cancer Cohort (4C) Study. In fully adjusted logistic regression models, per SD increment of branched-chain AAs, aromatic asparagine, alanine, glutamic acid, homoserine,...
Abstract Background Whether smoking modifies the associations of diabetes and risk factor management with subsequent cardiovascular disease (CVD), whether related CVD differs among people without are unclear. This study aimed to examine interactions smoking, diabetes, in relation incident CVD. Methods nationwide, population-based, prospective cohort 20 communities from various geographic regions recruited adults aged 40 years or older during 2011–2012. The follow-up survey was conducted...
Brief ischemic episodes confer marked protection against myocardial stunning 1-3 d later (late preconditioning [PC] stunning). The mechanism of this powerful protective effect is poorly understood. Although protein kinase C (PKC) has been implicated in PC infarction, it unknown whether triggers late stunning. In addition, the entire PKC hypothesis remains controversial, possibly because effects inhibitors on have not correlated with their activity and/or translocation vivo. Thus, conscious...
OBJECTIVE Comprehensive assessment of serum bile acids (BAs) aberrations before diabetes onset remains inconclusive. We examined the association BA profile and coregulation with risk developing type 2 mellitus (T2DM) among normoglycemic Chinese adults. RESEARCH DESIGN AND METHODS tested 23 species in subjects incident (n = 1,707) control matched by propensity score (including age, sex, BMI, fasting glucose) from China Cardiometabolic Disease Cancer Cohort (4C) Study, which was composed...
BackgroundNational investigations of age-specific modifiable risk profiles for diabetes are crucial to promote personalised strategies the prevention and control diabetes, particularly in countries such as China, which is experiencing both a epidemic rapidly ageing population. We aimed examine associations 12 potentially socioeconomic, lifestyle, metabolic factors with nationwide prospective cohort Chinese adults across four age groups.MethodsWe analysed data from China Cardiometabolic...
We aim to investigate the impact of ideal cardiovascular health metrics (ICVHMs) on association between famine exposure and adulthood diabetes risk.This study included 77,925 participants from China Cardiometabolic Disease Cancer Cohort (4C) Study who were born around time Chinese Great Famine free at baseline. They divided into three groups according birth year, including nonexposed (1963-1974), fetal exposed (1959-1962), childhood (1949-1958). Relative risk regression was used examine...
Background Education attainment can improve life expectancy and guide healthy behaviours throughout an entire lifetime. A nationwide longitudinal study of the association education status with risk hypertension its control in China is lacking. Methods The Cardiometabolic Disease Cancer Cohort Study a multicentre, population-based, prospective cohort study. We performed baseline survey from 2011 to 2012. follow-up visit was conducted during 2014–2016. 101 959 subjects were included final data...