A5081649873- Liver Disease Diagnosis and Treatment
- Chronic Kidney Disease and Diabetes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Protease and Inhibitor Mechanisms
- Alcohol Consumption and Health Effects
- Hormonal and reproductive studies
- Wound Healing and Treatments
- Gout, Hyperuricemia, Uric Acid
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Diabetes Management and Research
- Blood Pressure and Hypertension Studies
- Sleep and related disorders
- S100 Proteins and Annexins
- Dialysis and Renal Disease Management
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Peptidase Inhibition and Analysis
- Hypothalamic control of reproductive hormones
- Pregnancy and preeclampsia studies
- Nutrition, Genetics, and Disease
- Stress Responses and Cortisol
- Gestational Diabetes Research and Management
- Diabetic Foot Ulcer Assessment and Management
- Pharmacology and Obesity Treatment
Sun Yat-sen Memorial Hospital
2015-2024
Sun Yat-sen University
2015-2024
North China University of Science and Technology
2018
Background Education attainment can improve life expectancy and guide healthy behaviours throughout an entire lifetime. A nationwide longitudinal study of the association education status with risk hypertension its control in China is lacking. Methods The Cardiometabolic Disease Cancer Cohort Study a multicentre, population-based, prospective cohort study. We performed baseline survey from 2011 to 2012. follow-up visit was conducted during 2014–2016. 101 959 subjects were included final data...
Background: Excessive expression of matrix metalloproteinase-9 (MMP-9) is deleterious to the cutaneous wound-healing process in context diabetes. The aim present study was explore whether a cationic star-shaped polymer consisting ß-cyclodextrin (ß-CD) core and poly(amidoamine) dendron arms (ß-CD-[D 3 ] 7 ) could be used as gene carrier small interfering RNA (siRNA) reduce MMP-9 for enhanced diabetic wound healing. Methods: cytotoxicity ß-CD-(D investigated by...
Background: In recent years, the impact of visceral fat accumulation on renal damage has garnered significant attention. However, whether contributes to incidence both albuminuria and chronic kidney disease (CKD) is still uncertain. Our objective look into possible correlation between adiposity incident increased urinary albumin excretion CKD. Methods: We analyzed data from a cohort 9916 subjects aged 40 years above. As an innovative convenient biomarker distribution, index (VAI) was...
OBJECTIVE To explore the association of serum retinol-binding protein 4 (RBP4) levels and risk for development type 2 diabetes in individuals with prediabetes. RESEARCH DESIGN AND METHODS A population-based prospective study was conducted among 1,011 Chinese participants prediabetes (average age 55.6 ± 7.2 years). Incident diagnosed according to American Diabetes Association 2010 criteria. Serum RBP4 were measured using a commercially available ELISA. We analyzed incident Cox proportional...
Rational measures in estimating adiposity distribution diabetic patients has yet to be validated. This study aims provide insight about the possible links between routinely available body parameters and development of both diabetes insulin resistance.We performed a population-based cross-sectional 9496 subjects aged 40 years or older. All including mass index (BMI), waist circumference (WC), waist-hip ratio (WHR), waist-height (WHtR), visceral (VAI), (BAI) lipid accumulation product (LAP)...
Objectives The effects of lipid metabolism disorder on renal damage have drawn much attention. Using the fatty liver index (FLI) as a validated indicator hepatic steatosis, this study aims to provide insight about possible links between and development chronic kidney disease (CKD). Setting Hospital. Participants We performed population-based 9436 subjects aged 40 years or older. Primary secondary outcome measures FLI is calculated using an algorithm based body mass index, waist...
We investigated the effect of angiotensin II (Ang II) on matrix metalloproteinase-1 (MMP-1)/tissue inhibitor (TIMP-1) balance in regulating collagen metabolism diabetic skin. Skin tissues from model were collected, and primary cultured fibroblasts treated with Ang receptor inhibitors before treatment. The type I (Coll I) III III) measured by histochemistry. expressions transforming growth factor-β (TGF-β), MMP-1, TIMP-1 propeptides types procollagens skin quantified using polymerase chain...
Although dyslipidemia is related to the pathogenesis of renal insufficiency, which routinely available lipid measure more applicable in estimation kidney function still uncertain. Our objective was evaluate inconsistent associations profiles with both albuminuria and chronic disease (CKD). We performed a population-based study 9730 subjects aged 40 years or older. Definitions abnormalities albumin excretion were according latest guidelines American Diabetes Association's Standards Medical...
Abstract Background Although obesity and heart rate (HR) were closely related to the prevalence development of type 2 diabetes mllitus (T2DM), few studies have shown a co‐association effect them on T2DM. We aimed at assessing interactive effects HR with T2DM in Chinese population, providing exact cutpoint risk threshold for blood glucose high HR. Materials Methods In Risk Evaluation cAncers diabeTic Individuals: lONgitudinal study (REACTION) cohorts ( N = 8398), relationship between was...
Background It is challenging for clinicians to distinguish adrenocortical carcinoma (ACC) from benign adenomas (ACA) in their early stages. This study explored the value of serum steroid profiling as a complementary biomarker malignancy diagnosis ACC other than diameter and influence sex functional status. Methods In this retrospective study, matched cohort patients diagnosed with either or ACA based on histopathology was meticulously paired 1:1 ratio according sex, age, Eight steroids...
To explore the effects of high expression MMP9 on biological behaviors fibroblasts. High glucose and hyperhomocysteine were used to induce in skin Cell proliferation was detected by flow cytometry cell viability CCK-8. ELISA assay detect collagen (hydroxyproline) secretion. Scratch test employed evaluate horizontal migration cells transwell method vertical cells. The mRNA protein expressions its protease activity significantly higher treated with than those control group. At same time,...
The high level of matrix metalloproteinase 9 (MMP9) is thought to slow down the healing diabetic foot ulcers. Whether it can influence biological behaviors skin fibroblasts and affect wound still unclear. present study aimed observe changes in rat dermal induced by expression MMP9 clarify possible mechanisms for foot.A cell model fibroblast with was established co-culture glucose (22.0 mmol/L) homocysteine (100 μmol/L). A control group incubated normal (5.5 mmol/L). Realtime PCR, ELISA...
Background Serum γ - glutamyltransferase (GGT) is implicated in the pathogenesis of endothelial dysfunction and atherosclerosis. Albuminuria a marker damage correlated with structural functional integrity vasculature. Our objective was to evaluate association between serum GGT level prevalence albuminuria Chinese population. Materials Methods We conducted population-based cross-sectional study 9,702 subjects aged 40 years or older. Increased urinary albumin excretion defined according...
Diabetic kidney disease (DKD) is a kind of common microvascular complication diabetes. This study aims to explore the possible links between blood sugar level and albuminuria, providing exact cut point "risk threshold" for glucose with DKD.The relationship albuminuria was modeled using linear logistic regression in REACTION cohorts (N= 8932). Odds ratios (ORs) 95% confidence intervals (CIs) were calculated by model. Two-slope used simulate associations ACR.We found that increase ACR...
Epidemiological evidence suggests that lipid parameters are related to the progression of chronic kidney disease (CKD). Nevertheless, prospective studies comprehensively assess effect routinely available measures on development CKD lacking. The aim this study was longitudinally influence metabolism indicators presence in a large community-based population. We conducted cohort at Sun Yat-sen Memorial Hospital, China, with 5345 patients 40 years or older. Cox regression models were conducted,...
Background Research has shown that gonadal hormones are involved in metabolic pathways relevant to syndrome (MetS). Nevertheless, no longitudinal study been conducted on the association between SHBG and MetS Chinese. The objective of our was determine whether there is any middle-aged elderly males China. Methods A total 531 eligible male subjects, aged above 40 years or older, without at baseline, were recruited. Sex hormone binding globulin (SHBG), testosterone (TT), follicle-stimulating...
Menopause can affect the physiological timing system, which could result in circadian rhythm changes and development of napping habits. Whether longtime postmenopausal women is associated with cardiovascular disease is, however, still debated. The present study aims to investigate this association.We conducted a population-based 4,616 Chinese women. Information on sleep duration was self-reported. Framingham General Cardiovascular Risk Score calculated used identify participants at high risk...
Hypogonadism in men is related to the deterioration of general health. However, association between lipid overaccumulation and ageing-related hypogonadism remains an undetermined concept. We aimed provide insight into possible links accumulation product (LAP) late-onset (LOH).Sun Yat-sen Memorial Hospital Sun University.We included a population sample 997 subjects aged 40 years or older.The LAP was calculated by gender-specific equations using waist circumference (WC) triglyceride (TG). LOH...
Background Numerous observational studies have shown that liver enzymes correlated with diabetes mellitus (DM) risk significantly, but limited showed whether different obesity subgroups present the same correlation. Our objective was to evaluate association of DM in based on a middle-aged Chinese population. Methods We conducted population-based cross-sectional study and surveyed 9,916 people aged 40 years above. A two-slope linear regression model used analyze cutoff points risk. Restricted...
Large-scale epidemiological investigations worldwide have shown that dietary glycemic load is associated with metabolic diseases, including diabetes. However, only a few studies examined the correlations between and blood glucose lipids in Chinese diabetic patients. Therefore, this study aimed to determine these southeastern China.201 patients newly diagnosed type 2 diabetes 126 participants normal were enrolled at Sun Yat-sen Memorial Hospital, Guangdong Province. Carbohydrate intake...