A5101676718- Cardiovascular Health and Risk Factors
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Birth, Development, and Health
- Nutritional Studies and Diet
- Metabolism, Diabetes, and Cancer
- Obesity, Physical Activity, Diet
- Diet, Metabolism, and Disease
- Blood Pressure and Hypertension Studies
- Liver Disease Diagnosis and Treatment
- Cardiovascular Disease and Adiposity
- Diabetes Treatment and Management
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes Management and Education
- Health, Environment, Cognitive Aging
- Gestational Diabetes Research and Management
- Chronic Kidney Disease and Diabetes
- Diet and metabolism studies
- Vitamin D Research Studies
- Sleep and related disorders
- Cancer Risks and Factors
- Health disparities and outcomes
- Cardiac Health and Mental Health
- Sleep and Work-Related Fatigue
- Bone health and osteoporosis research
- Health Promotion and Cardiovascular Prevention
Jiangxi Provincial People's Hospital
2015-2025
Gilead Sciences (United States)
2023-2025
Nanchang University
2019-2024
Sun Yat-sen Memorial Hospital
2020
Sun Yat-sen University
2020
Harbin Engineering University
2009-2017
Shanghai Jiao Tong University
2016
Shanghai Clinical Research Center
2016
Lishen (China)
2012
OBJECTIVE To investigate whether the association between insulin resistance and cardiovascular disease (CVD) differs by glucose tolerance status. RESEARCH DESIGN AND METHODS We analyzed a nationwide sample of 111,576 adults without CVD at baseline, using data from China Cardiometabolic Disease Cancer Cohort Study. Insulin was estimated sex-specific HOMA (HOMA-IR) quartiles for participants with normal tolerance, prediabetes, or diabetes, separately, 1 SD HOMA-IR overall study participants....
To demonstrate whether abnormal glucose metabolism (diabetes and prediabetes) is associated with increased risk for cancer in the Chinese population to identify factors that modify of among individuals metabolism.Between 2011 2012, 259 657 community-dwelling adults, aged 40 years older, were recruited from 25 centers across mainland China participant baseline survey REACTION study, follow-up investigations performed 3, 5, 10 later. Detailed questionnaires about lifestyles, physical...
OBJECTIVE Uncertainty remains regarding the predictive value of various glycemic measures as they relate to risk diabetes and its complications. Using cutoffs recommended by American Diabetes Association’s 2010 criteria, we determined associations fasting plasma glucose (FPG), 2-h postload (2h-PG), HbA1c with outcomes. RESEARCH DESIGN AND METHODS Baseline medical history, FPG, 2h-PG, were obtained from a population-based cohort 193,846 adults aged ≥40 years in China during 2011–2012. A...
Whether optimal cardiovascular health metrics may counteract the risk of events among patients with prediabetes or diabetes is unclear.
National investigations on age-specific modifiable risk factor profiles for cardiovascular disease (CVD) and mortality are scarce in China, the country that is experiencing a huge cardiometabolic burden exacerbated by population ageing.This nationwide prospective cohort study of 193,846 adults China Cardiometabolic Disease Cancer Cohort Study, 2011-2016. Among 139,925 participants free from CVD at baseline, we examined hazard ratios population-attributable percentages (PAR%s) all-cause...
Although previous studies suggest that amino acids (AAs) and microbiota-related metabolites (MRMs) are associated with type 2 diabetes mellitus (T2DM), the results remain unclear among normoglycemic populations. We test 28 serum AAs 22 MRMs in 3,414 subjects incident matched controls from China Cardiometabolic Disease Cancer Cohort (4C) Study. In fully adjusted logistic regression models, per SD increment of branched-chain AAs, aromatic asparagine, alanine, glutamic acid, homoserine,...
Abstract Background Whether smoking modifies the associations of diabetes and risk factor management with subsequent cardiovascular disease (CVD), whether related CVD differs among people without are unclear. This study aimed to examine interactions smoking, diabetes, in relation incident CVD. Methods nationwide, population-based, prospective cohort 20 communities from various geographic regions recruited adults aged 40 years or older during 2011–2012. The follow-up survey was conducted...
OBJECTIVE Comprehensive assessment of serum bile acids (BAs) aberrations before diabetes onset remains inconclusive. We examined the association BA profile and coregulation with risk developing type 2 mellitus (T2DM) among normoglycemic Chinese adults. RESEARCH DESIGN AND METHODS tested 23 species in subjects incident (n = 1,707) control matched by propensity score (including age, sex, BMI, fasting glucose) from China Cardiometabolic Disease Cancer Cohort (4C) Study, which was composed...
BackgroundNational investigations of age-specific modifiable risk profiles for diabetes are crucial to promote personalised strategies the prevention and control diabetes, particularly in countries such as China, which is experiencing both a epidemic rapidly ageing population. We aimed examine associations 12 potentially socioeconomic, lifestyle, metabolic factors with nationwide prospective cohort Chinese adults across four age groups.MethodsWe analysed data from China Cardiometabolic...
We aim to investigate the impact of ideal cardiovascular health metrics (ICVHMs) on association between famine exposure and adulthood diabetes risk.This study included 77,925 participants from China Cardiometabolic Disease Cancer Cohort (4C) Study who were born around time Chinese Great Famine free at baseline. They divided into three groups according birth year, including nonexposed (1963-1974), fetal exposed (1959-1962), childhood (1949-1958). Relative risk regression was used examine...
Background Education attainment can improve life expectancy and guide healthy behaviours throughout an entire lifetime. A nationwide longitudinal study of the association education status with risk hypertension its control in China is lacking. Methods The Cardiometabolic Disease Cancer Cohort Study a multicentre, population-based, prospective cohort study. We performed baseline survey from 2011 to 2012. follow-up visit was conducted during 2014–2016. 101 959 subjects were included final data...
Prediabetes and its pathophysiology remain important issues. We aimed to examine the cluster characteristics of prediabetes explore their associations with developing diabetes complications based on 12 variables representing body fat, glycemic measures, pancreatic β cell function, insulin resistance, blood lipids, liver enzymes. A total 55,777 individuals from China Cardiometabolic Disease Cancer Cohort (4C) were classified at baseline into six clusters. During a median 3.1 years follow-up,...
Background Previous studies reported that early‐life exposure to undernutrition is associated with the risk of diabetes mellitus and metabolic syndrome in adulthood, but association cardiovascular disease ( CVD ) later life remains unclear. The current study aimed investigate whether Chinese famine early . Methods Results We used data from REACTION (Risk Evaluation Cancers Diabetic Individuals: A Longitudinal Study), which recruited a total 259 657 community‐dwelling adults aged 40 years or...
OBJECTIVE We aimed to determine the individual and combined associations of lifestyle metabolic factors with new-onset diabetes major cardiovascular events among a Chinese population aged ≥40 years. RESEARCH DESIGN AND METHODS Baseline information, waist circumference, blood pressure, lipid profiles, glycemic status were obtained in nationwide, multicenter, prospective study 170,240 participants. During up 5 years follow-up, we detected 7,847 individuals according American Diabetes...
A number of primary studies suggested that active smoking could be independently associated with incident diabetes. However less is known about the effect and cessation on glycemic control in patients The aim this study was to evaluate associations diabetic patients.The present a cross-sectional 10 551 men 15 297 women diabetes from Risk Evaluation cAncers Chinese diabeTic Individuals: lONgitudinal (REACTION) study. factors for association were evaluated using logistic regression models....
The updated definition of hypertension by the American College Cardiology (ACC) and Heart Association (AHA) is an important paradigm shift has lead to extensive discussion. We aimed examine association between blood pressure (BP) categories risk cardiovascular diseases (CVDs) with potential modifications from other health metrics (CVHMs).This prospective study included 91,204 participants ≥40 years recruited 20 community sites across mainland China. Participants were followed up during...
The 24-hour urinary calcium excretion (UCaE) not only serves as an important indicator of metabolism balance but also correlates with metabolic diseases. However, the distribution UCaE and its relationship bone are unknown. To investigate association metabolism. In this multicenter cross-sectional study, 1239 participants underwent physical examinations at 9 tertiary hospitals. Multivariate linear regression was used to explore associated UCaE. excretion/urinary creatinine (UCaE/Ucr)...
Objective: To investigate the association between serum 25-hydroxyvitamin D [25(OH)D] levels and 24-h urinary calcium excretion (24-h UCaE) hypercalciuria in Chinese adults. Methods: This cross-sectional study was conducted from March 2022 to 2023 nine cities China included 1 239 residents. Demographic characteristics were collected through questionnaires physical examinations, fasting blood samples assessed for bone metabolism indicators, urine used determine UCaE. Multiple linear...
Measures of pain sensitivity have potential relevance for patient care. We previously identified a subgroup people at risk ongoing characterized by genetic AND psychological factors. Here, we report planned secondary analyses examining the effect personalized interventions on outcomes. Two hundred and sixty-one healthy individuals with COMT SNP rs6269 AA genotype Pain Catastrophizing Scale scores 5 or higher received exercise-induced muscle injury, followed randomly assigned treatment: (1)...