A5031470604- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Reproductive Biology and Fertility
- Ovarian function and disorders
- Pregnancy and Medication Impact
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive Health and Technologies
- Sperm and Testicular Function
- Gynecological conditions and treatments
- Pregnancy and preeclampsia studies
- Immune Cell Function and Interaction
- Ectopic Pregnancy Diagnosis and Management
- Reproductive Physiology in Livestock
- Prenatal Screening and Diagnostics
- Ginseng Biological Effects and Applications
- Immunotherapy and Immune Responses
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- Minerals Flotation and Separation Techniques
- Metal Extraction and Bioleaching
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Extraction and Separation Processes
- Uterine Myomas and Treatments
- Preterm Birth and Chorioamnionitis
- Endometrial and Cervical Cancer Treatments
Shenzhen Zhongshan Urological Hospital
2016-2025
Hunan Institute of Mental Health
2025
Central South University
2023-2025
Second Xiangya Hospital of Central South University
2024-2025
Southeast University
2025
Zhengzhou University
2024
Xi'an Honghui Hospital
2023
Xi'an Jiaotong University
2023
Chengdu Second People's Hospital
2019-2022
Detection Limit (United States)
2022
The immune responses during the initiation and invasion stages of human lung adenocarcinoma (LUAD) development are largely unknown. Here, we generated a single-cell RNA sequencing map to decipher dynamics LUAD development. We found that T follicular helper (Tfh)-like cells, germinal center B dysfunctional CD8+ cells increase tumor initiation/invasion form tertiary lymphoid structure (TLS) inside tumor. This TLS starts with an aggregation CD4+ generation CXCL13-expressing Tfh-like followed by...
Objective This study was conducted to determine the influence of number CD138 + cells in proliferative endometrium on pregnancy outcomes. Methods retrospective cohort from January August 2018. A total 664 infertile women who were not diagnosed with chronic endometritis (CE) and had received respective antibiotic treatment studied. Immunostaining performed for plasmacyte marker CD138. The CD138+ compared mid-luteal phases same patients without therapy. Infertile separated into three groups...
Abstract Purpose: Lipid rafts, specialized domains in cell membranes, function as physical platforms for various molecules to coordinate a variety of signal transduction processes. Flotinllin-1 (FLOT1), marker lipid is involved the progression cancer, but precise mechanism remains unclear. The aim present study was examine role FLOT1 on tumorigenesis breast cancer cells and its clinical significance disease. Experimental Design: expression analyzed 212 paraffin-embedded, archived samples by...
Modulation of autophagy has been increasingly regarded as a promising cancer therapeutic approach. In this study, we screened several ginsenosides extracted from Panax ginseng and identified ginsenoside Ro (Ro) novel inhibitor. blocked the autophagosome-lysosome fusion process by raising lysosomal pH attenuating cathepsin activity, resulting in accumulation autophagosome marker MAP1LC3B/LC3B SQSTM1/p62 (sequestosome 1) various esophageal cell lines. More detailed studies demonstrated that...
Abstract Problem The definition of chronic endometritis (CE) differs among studies, and currently, there is no accepted consensus. This study aimed to establish the minimum number immunohistochemical analysis CD138 + plasma cells identify a clinically relevant CE. Method We performed retrospective on 716 infertile patients who never did CE respective antibiotic treatment before. Samples were obtained by endometrial scratching in mid‐luteal phase before IVF‐ET treatment. distribution analyzed...
Problem The role of ILT 4 + DC s in healthy fertile controls and patients with recurrent miscarriages ( RM ) implantation failure RIF is unclear. Method study We studied the expression from peripheral blood endometrial samples by flow cytometry immunohistochemistry analysis. Endometrial Foxp3 was also investigated using immunohistochemistry. Results In blood, there a significant increase percentage compared . presence even more prominent endometrium Moreover, strong correlation between...
Background: The risk of adverse pregnancy outcomes is increased by having a polycystic ovary syndrome (PCOS) diagnosis. However, the confounders in previous studies preclude firm conclusions, and further are warranted. Objectives: To investigate whether PCOS affects complications infertile women undergoing their first vitro fertilization (IVF) treatment, taking into account important confounders. Methods: We performed retrospective cohort study 7678 women, including 666 with 7012 controls...
To develop a predictive tool in the form of Nomogram based on Cox regression model, which incorporates impact length treatment cycles outcome live birth, to evaluate probability infertile couples having birth after one or more complete In Vitro Fertilization (IVF), and provide patients with risk assessment that is easy understand visualize. A retrospective study for establishing prediction model was conducted reproductive center Shenzhen Zhongshan Obstetrics & Gynecology Hospital (formerly...
Calmodulin (CaM) plays a crucial role in sperm function. Studies have reported that proteins containing IQ motif interact with CaM, subsequently engaging downstream target known as calmodulin-binding (CaMBPs). It is the loss of interaction between IQCN and CaM mainly manifested decreased motility, leading to fertilization failure male infertility. However, no relevant reports been published detailing which CaMBPs exist mechanisms by they are regulated. In this study, we conducted...
Objective: To investigate the association between serum 25-hydroxyvitamin D [25(OH)D] levels and 24-h urinary calcium excretion (24-h UCaE) hypercalciuria in Chinese adults. Methods: This cross-sectional study was conducted from March 2022 to 2023 nine cities China included 1 239 residents. Demographic characteristics were collected through questionnaires physical examinations, fasting blood samples assessed for bone metabolism indicators, urine used determine UCaE. Multiple linear...
Abstract Non-obstructive azoospermia (NOA), a severe form of male infertility, is often suspected to be linked currently undefined genetic abnormalities. To explore the basis this condition, we successfully sequenced ~650 infertility-related genes in 757 NOA patients and 709 fertile males. We evaluated contributions rare variants etiology by identifying individual showing nominal associations testing burden given biological process as whole. found significant excess rare, non-silent that are...
Problem Human chorionic gonadotropin (hCG) and regulatory T cells (Tregs) have been suggested to play important roles during the initial stage of pregnancy. However, clinical relevance mechanism effects hCG on Treg functions in women with recurrent implantation failure (RIF) remain be elucidated. Method study Thirty-four RIF twenty-three control were included study. Endometrial peripheral Tregs analyzed by immunohistochemistry flow cytometry, respectively. generated from naïve CD4+...
Ca(2+) is the main element of many pulp capping materials that are used to promote regeneration tertiary dentin, but underlying molecular mechanism not clear. In this study, we found increased expression odontoblastic differentiation marker gene DSPP and promoted mineralization DPSCs, inhibited ALP activity. increases endogenous BMP2, which activates Smad1/5/8 pathway promotes Smad1-Runx2 Runx2-DSPP interaction in DPSCs. Inhibition with dorsomorphin partially blocked Runx2 activity; however,...
Long non-coding RNAs (lncRNAs) have been shown to be crucial regulators in numerous human diseases. However, little is known about their effects on early recurrent miscarriage (RM). Here we aimed investigate the role of lncRNA EPB41L4A-AS1 placental trophoblast cell metabolic reprogramming, which might involved pathogenesis RM. After microarray and GEO database analyses, found that was significantly increased RM tissue, this increase may relate estradiol-mediated upregulation PGC-1α....
The presence of dendritic cells (DCs) and associated cytokines in follicular fluid (FF) from patients with polycystic ovary syndrome (PCOS) remains unknown.FF was collected PCOS severe male factor infertility (control) at the day transvaginal oocyte retrieval. Phenotypes DC were detected by flow cytometry, TNF-α, IL-6, IL-10, IL-23 assessed ELISA.A significant decrease percentage found (16.22±5.5%) compared control (21.27±5.5%, P<.01). E2 on hCG administration correlated positively mean...