A5101946483- Ovarian function and disorders
- Reproductive Biology and Fertility
- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Transportation Planning and Optimization
- Assisted Reproductive Technology and Twin Pregnancy
- Pregnancy and preeclampsia studies
- Evacuation and Crowd Dynamics
- Electrocatalysts for Energy Conversion
- Ovarian cancer diagnosis and treatment
- Electromagnetic Fields and Biological Effects
- Sperm and Testicular Function
- Autophagy in Disease and Therapy
- Fuel Cells and Related Materials
- Urban Transport and Accessibility
- interferon and immune responses
- Railway Systems and Energy Efficiency
- Cutaneous Melanoma Detection and Management
- Spectroscopy Techniques in Biomedical and Chemical Research
- Gynecological conditions and treatments
- Transportation and Mobility Innovations
- Inflammasome and immune disorders
- Traffic Prediction and Management Techniques
- MicroRNA in disease regulation
- RNA modifications and cancer
Shanghai First Maternity and Infant Hospital
2011-2024
Shenzhen Zhongshan Urological Hospital
2020-2024
Tongji University
2011-2024
Zhejiang University
2011-2023
Center for Drug Evaluation and Research
2023
Dalian Medical University
2023
First Affiliated Hospital of Dalian Medical University
2023
Huashan Hospital
2023
Fudan University
2023
Zhejiang Provincial People's Hospital
2022
Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder in reproductive women characterized by polycystic ovaries, hyperandrogenism chronic anovulation. Abnormal folliculogenesis considered as characteristic of PCOS. Our aim to identify the altered circRNA expression profile exosomes isolated from follicular fluid (FF) PCOS patients investigate molecular function exosomal circRNA, vital mediator microenvironment, aetiology pathobiology In this study, FF were compared...
N1-methyladenosine (m1A) is one of the important post-transcriptional modifications in RNA and plays an role promoting translation or decay m1A-methylated messenger (mRNA), but "reader" protein exact biological m1A remain to be determined. Here, we identified that nine potential proteins including YTH domain family heterogeneous nuclear ribonucleoprotein by mass spectrometry, among them, domain-containing 3 (YTHDF3), could bind directly m1A-carrying RNA. YTHDF3 was then negatively regulate...
Abstract Polycystic ovary syndrome (PCOS) is a common endocrine disorder associated with infertility and poor reproductive outcomes. The follicular fluid (FF) microenvironment plays crucial role in oocyte development. This review summarizes evidence elucidating the alterations FF composition PCOS. Various studies demonstrated pronounced proinflammatory milieu PCOS FF, characterized by increased levels of cytokines, including but not limited to interleukin-6 (IL-6), tumor necrosis factor α,...
Abstract Cigarette smoking is associated with an increased incidence of chronic obstructive pulmonary disease (COPD). In this study, we hypothesized that liquiritin apioside (LA), a main flavonoid component from Glycyrrhiza uralensis , had antioxidant properties by inducing glutathione (GSH) biosynthesis via the inhibition cytokines and protected lung epithelial cells against cigarette smoke‐mediated oxidative stress. A549 were treated smoke extract (CSE) and/or LA. ICR mice exposed to (CS)...
Background: The risk of adverse pregnancy outcomes is increased by having a polycystic ovary syndrome (PCOS) diagnosis. However, the confounders in previous studies preclude firm conclusions, and further are warranted. Objectives: To investigate whether PCOS affects complications infertile women undergoing their first vitro fertilization (IVF) treatment, taking into account important confounders. Methods: We performed retrospective cohort study 7678 women, including 666 with 7012 controls...
Polymorphisms in the follicle-stimulating hormone receptor (FSHR) gene are reported to be associated with ovarian response controlled hyperstimulation (COH), although there remains some discordance between studies. Here, using largest patient sample date, we evaluated association of p.Ser680Asn (S(680)N) polymorphism FSHR outcome COH.Cohort study.Medical academy and hospital.A total 1250 infertile Chinese women undergoing IVF/ICIS-ET treatment were included.The an was analysed. Genotyping...
Abstract Aim This study aimed to compare the efficacy of long‐ and short‐acting gonadotropin‐releasing hormone agonist on clinical outcomes in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) long protocol cycles. Methods In this retrospective study, 478 patients were enrolled from October 2012 November 2014. The pituitary downregulation result, serum levels, gonadotropin (Gn) dose during controlled ovarian hyperstimulation, outcome IVF/ICSI–embryo transfer compared between...
Abstract Deterioration of the endometrial environment is an essential cause recurrent miscarriage (RM). However, current studies in terms amino acid metabolic characterization and autophagy are still inadequate. We tried to (1) identify alternation metabolite profiles RM endometrium; (2) investigate expression autophagy-related proteins RM; (3) elucidate association between metabolism RM. Our results showed that glutamine metabolites were up-regulated endometrium women. The levels...
RNA epigenetic modification take part in many biology processes, and the N6-methyladenosine (m 6 A) methylation of specific mRNAs endometrial cancer (EC) tissues play a key role regulating tumorigenicity EC, but mechanism still unknown need to be investigated future.Here, we found that m A reader protein YTHDF2 expression was significantly upregulated EC compare tumor adjacent tissues, then identified inhibit proliferation invasion cell lines.Mechanistically, bind sites target transcripts...
The current study was undertaken to investigate the relationship between antimüllerian hormone (AMH) and polycystic ovarian syndrome (PCOS) phenotypes determine whether AMH is associated with pregnancy outcomes in infertile women undergoing their first vitro fertilization (IVF) treatment.We performed a retrospective cohort of 2973 women, including 418 PCOS IVF treatment at private fertility center from January 2014 March 2018. Women were stratified into three groups using cutoffs defined by...
The aim of this work was to identify the transcriptomic characteristics endometrium in normoweight and overweight/obese polycystic ovary syndrome (PCOS) potentially underlying pathogenesis. This study included 38 patients undergoing vitro fertilization: 22 women with PCOS 16 matched controls. Each groups subdivided into (body mass index (BMI) < 25 kg/m2) (BMI ≥25 subgroups. Endometrium samples were collected secretory phase from controls or a modeled using daily administration progesterone...
Polycystic ovary syndrome (PCOS) is a complex common endocrine disorder affecting women of reproductive age. Ovulatory dysfunction recognized as primary infertile factor, however, even when ovulation medically induced and restored, PCOS patients continue to experience reduced cumulative pregnancy rates higher spontaneous miscarriage rate. Hyperandrogenism, hallmark feature PCOS, affects ovarian folliculogenesis, endometrial receptivity, the establishment maintenance pregnancy....