A5101578573- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Reproductive System and Pregnancy
- RNA modifications and cancer
- Immune Cell Function and Interaction
- interferon and immune responses
- Pregnancy and preeclampsia studies
- Viral Infectious Diseases and Gene Expression in Insects
- COVID-19 Impact on Reproduction
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Cancer-related gene regulation
- Advanced DC-DC Converters
- Insect Resistance and Genetics
- Pregnancy and Medication Impact
- MicroRNA in disease regulation
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Invertebrate Immune Response Mechanisms
- Silk-based biomaterials and applications
- Renal and related cancers
- TGF-β signaling in diseases
- Sirtuins and Resveratrol in Medicine
- Sesquiterpenes and Asteraceae Studies
- Advanced Biosensing Techniques and Applications
Eighth Affiliated Hospital of Sun Yat-sen University
2022-2025
Sun Yat-sen University
2022-2025
Tongji University
2021-2024
Shanghai First Maternity and Infant Hospital
2019-2021
Creative Commons
2020
Chinese Academy of Medical Sciences & Peking Union Medical College
1991-2017
Zhejiang University
2015
Fuzhou University
2014
Zhejiang Sci-Tech University
2006-2013
The Dainippon Silk Foundation
2008
2019 novel coronavirus disease has resulted in thousands of critically ill patients China, which is a serious threat to people's life and health. Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) was reported share the same receptor, angiotensin-converting enzyme (ACE2), with SARS-CoV. Here, based on public single-cell RNA-sequencing database, we analyzed mRNA expression profile putative receptor ACE2 AXL tyrosine kinase (AXL) early maternal-fetal interface. The result indicates...
Regulated cell death (RCD) plays a fundamental role in placental development and tissue homeostasis. Placental relies upon effective implantation invasion of the maternal decidua by trophoblast an immune tolerant environment maintained various cells at maternal-fetal interface. Although placenta can affect fetal even cause pregnancy-related diseases, accumulating evidence has revealed that several regulated were found interface under physiological or pathological conditions, exact types...
N1-methyladenosine (m1A) is one of the important post-transcriptional modifications in RNA and plays an role promoting translation or decay m1A-methylated messenger (mRNA), but "reader" protein exact biological m1A remain to be determined. Here, we identified that nine potential proteins including YTH domain family heterogeneous nuclear ribonucleoprotein by mass spectrometry, among them, domain-containing 3 (YTHDF3), could bind directly m1A-carrying RNA. YTHDF3 was then negatively regulate...
Preeclampsia is a pregnancy-specific disorder that major cause of maternal and fetal morbidity mortality with prevalence 6–8% pregnancies. Although impaired trophoblast invasion in early pregnancy known to be closely associated preeclampsia, the underlying mechanisms remain elusive. Here we revealed lysyl oxidase (LOX) LOX-like protein 2 (LOXL2) play critical role preeclampsia. Our results demonstrated LOX LOXL2 expression decreased preeclamptic placentas. Moreover, knockdown or suppressed...
Non-obstructive azoospermia (NOA) belongs to male infertility due spermatogenesis failure. However, evidence for cell type-specific abnormalities of disorders in NOA remains lacking. We performed single-cell RNA sequencing (scRNA-seq) and assay transposase-accessible chromatin (scATAC-seq) on testicular tissues from patients with obstructive azoospermia(OA) NOA. HE staining confirmed the structural seminiferous tubules patients. identified 12 germ subtypes (spermatogonial stem cell-0 (SSC0),...
Avian influenza virus (H5N1) has caused serious infections in human beings. This the potential to emerge as a pandemic threat humans. Effective vaccines against H5N1 are needed. A recombinant Bombyx mori baculovirus, Bmg64HA, was constructed for expression of HA protein displaying on viral envelope surface. The accounted approximately 3% total proteins silkworm pupae infected with virus. Using series separation and purification methods, pure Bmgp64HA isolated from these bioreactors. Aluminum...
Abstract Upon recognition of viral components by pattern receptors, including TLRs and retinoic acid–inducible gene I–like helicases, cells are activated to produce type I IFN, which plays key roles in host antiviral innate immune response. However, excessive IFN production may induce disorders, the mechanisms responsible for regulation have attracted much attention. Furthermore, activates downstream IFN/JAK/STAT pathway modulate expression a set genes against infection, but whether these...
Cervical cancer (CC) is one of the most common malignant tumors female reproductive system. And immune system disorder in patients results an increasing incidence rate and mortality rate. Pyroptosis system-related programmed cell death pathway that produces systemic inflammation by releasing pro-inflammatory intracellular components. However, diagnostic significance pyroptosis-related genes (PRGs) CC still unclear. Therefore, we identified 52 PRGs from TCGA database screened three...
RNA epigenetic modification take part in many biology processes, and the N6-methyladenosine (m 6 A) methylation of specific mRNAs endometrial cancer (EC) tissues play a key role regulating tumorigenicity EC, but mechanism still unknown need to be investigated future.Here, we found that m A reader protein YTHDF2 expression was significantly upregulated EC compare tumor adjacent tissues, then identified inhibit proliferation invasion cell lines.Mechanistically, bind sites target transcripts...
Immunosuppression induced by myeloid-derived suppressor cells (MDSCs) is one of the main obstacles to efficacy immunotherapy for cervical cancer. Recent studies on immunosuppressive ability MDSCs have primarily focused T cells, but effect B function still unclear. In a study clinical specimens, we found that accumulation in patients with cancer was accompanied high expression cell activating factor (BAFF) surface and interleukin (IL)-10-producing (B10) vivo. We absence BAFF could...
Non-obstructive azoospermia (NOA) belongs to male infertility due spermatogenesis failure. However, evidence for cell type-specific abnormalities of disorders in NOA remains lacking. We performed single-cell RNA sequencing (scRNA-seq) and assay transposase-accessible chromatin (scATAC-seq) on testicular tissues from patients with obstructive azoospermia(OA) NOA. HE staining confirmed the structural seminiferous tubules patients. identified 12 germ subtypes (spermatogonial stem cell-0 (SSC0),...
LED has promised to replace conventional light sources with impressive economic and environmental saving because of the realization high efficiency long life time sources. Reliability issue is a key factor affecting lighting quality system. Each system includes two major aspects; optical electrical driver. The driver one weakest components in luminaries they tend degrade rapidly increasing temperature. effect temperature on performance reliability analyzed this paper. A thermal simulation...