A5025854323- Venomous Animal Envenomation and Studies
- Insect and Pesticide Research
- Biochemical and Structural Characterization
- Healthcare and Venom Research
- Nicotinic Acetylcholine Receptors Study
- Pluripotent Stem Cells Research
- Epigenetics and DNA Methylation
- Reproductive Biology and Fertility
- Marine Invertebrate Physiology and Ecology
- Rabies epidemiology and control
- Seismic Imaging and Inversion Techniques
- Amphibian and Reptile Biology
- Zebrafish Biomedical Research Applications
- Hydraulic Fracturing and Reservoir Analysis
- CRISPR and Genetic Engineering
- Seismic Waves and Analysis
- Ubiquitin and proteasome pathways
- Immune Cell Function and Interaction
- Marine Toxins and Detection Methods
- interferon and immune responses
- Developmental Biology and Gene Regulation
- Renal and related cancers
- Invertebrate Immune Response Mechanisms
- Yersinia bacterium, plague, ectoparasites research
- Fish biology, ecology, and behavior
Minzu University of China
2023
PetroChina Southwest Oil and Gas Field Company (China)
2023
Leiden University
2018-2022
BGI Group (China)
2016-2020
China National GeneBank
2016
Northeast Agricultural University
2013-2015
Zhejiang University
2015
Johns Hopkins Medicine
2014
Johns Hopkins University
2014
Significance Ray-finned fishes form the largest and most diverse group of vertebrates. Establishing their phylogenetic relationships is a critical step to explaining diversity. We compiled comparative genomic database that provides genome-scale support for previous results used it resolve further some contentious in fish phylogeny. A vetted set exon markers identified this study promising resource current sequencing approaches significantly increase genetic taxonomic coverage tree life all...
Abstract Background The explosive radiation and diversification of the advanced snakes (superfamily Colubroidea) was associated with changes in all aspects shared venom system. Morphological included partitioning mixed ancestral glands into two discrete devoted for production or mucous respectively, as well location, size structural elements venom-delivering teeth. Evidence also exists homology among gland toxins expressed across snakes. However, despite evolutionary novelty snake venoms,...
Millions of years evolution have fine-tuned the ability venom peptides to rapidly incapacitate both prey and potential predators. Toxicofera reptiles are characterized by serous-secreting mandibular or maxillary glands with heightened levels protein expression. These core anatomical components toxicoferan system, which exists in myriad points along an evolutionary continuum. Neofunctionalisation toxins is facilitated positive selection at functional hotspots on ancestral proteins undergone...
Two-dimensional (2D) NMR logging has better application in the evaluation of fluid properties unconventional reservoirs by introducing longitudinal relaxation time (T1) to obtain more observational information. There are differences acquisition parameters between Schlumberger high-resolution instrument CMR-NG and Niumag 2D NMR experiments, comparison reveals following main parameters: the experiments high-frequency measurements, while borehole is...
The efficiency of cloning by somatic cell nuclear transfer (SCNT) has remained low. In most cloned embryos, epigenetic reprogramming is incomplete, and usually the genome hypermethylated. DNA methylation inhibitor 5-aza-2’-deoxycytidine (5-aza-dC) could improve developmental competence cow, pig, cat human SCNT embryos in previous studies. However, parameters 5-aza-dC treatment among species are different, whether enhance porcine still not been well studied. Therefore, this study, we treated...
Zebrafish (Danio rerio) represent an effective model biological material for human disease research, even personalized precision medicine. Thus, it is necessary to fully characterize their molecular information in order obtain a global metabolic profile. Here, spatially resolved metabolomics method whole-body zebrafish analysis was established based on air-flow-assisted desorption electrospray ionization-mass spectrometry imaging (AFADESI-MSI) system. Using the optimized experimental...
Fish venom remains a virtually untapped resource. There are so few fish toxin sequences for reference, which increases the difficulty to study toxins from venomous and develop efficient fast methods dig out genes or proteins. Here, we utilized Chinese yellow catfish (Pelteobagrus fulvidraco) as our research object, since it is representative species in Siluriformes with its glands embedded pectoral dorsal fins. In this study, set up an in-house database novel toxin-discovering protocol...
Incomplete DNA methylation reprogramming in cloned embryos leads to low cloning efficiency. Our previous studies showed that the epigenetic modification agents 5-aza-2'-deoxycytidine (5-aza-dC) or trichostatin A (TSA) could enhance developmental competence of porcine embryos. Here, we investigated genomic dynamics and specific gene expression levels during early embryonic development pigs. In this study, our results there was a typical wave demethylation remethylation centromeric satellite...
Nuclear reprogramming induced by somatic cell nuclear transfer is an inefficient process, and donor DNA methylation status thought to be a major factor affecting cloning efficiency. Here, the role of regulated 5-aza-2'-deoxycytidine (5-aza-dC) or 5-methyl-2'-deoxycytidine-5'-triphosphate (5-methyl-dCTP) in early development porcine cloned embryos was investigated. Our results showed that 5-aza-dC 5-methyl-dCTP significantly reduced increased global levels altered expression key genes cells....
The frameshift hypothesis is a widely accepted model of bird wing evolution. This postulates shift in positional values, or molecular-developmental identity, that caused change digit phenotype. synthesized developmental and paleontological data on homology. "most anterior digit" (MAD) presents an alternative view based changes transcriptional regulation the limb. molecular evidence for both hypotheses MAD expresses Hoxd13 but not Hoxd11 Hoxd12. I "signature" thought to characterize all...
As said by former United Nations Secretary-General Kofi Annan, “Snakebite is the most important tropical disease you’ve never heard of.” Listed as a priority neglected World Health Organization, snakebite envenoming (SBE) kills in excess of 125,000 people per year. However, due to complexity and overlap snake venom compositions, few reliable diagnostic methods for genus-/species-specific identification, which crucial successful SBE therapy, are available. Here, we develop strategy select...
There is increasing interest in the possibility of culturing organ-like tissues (organoids) vitro for biomedical applications. The ability to culture organoids would be greatly enhanced by having a functional circulation vitro. endothelial cell most important type this context. Endothelial cells can derived from pluripotent embryonic blastocyst aggregates called embryoid bodies. Here, we examine yield endothelial-like bodies (EBs) developed transgenic zebrafish fli:GFP and kdrl:GFP embryos....
Logs are valuable information for oil and gas fields as they help to determine the lithology of formations surrounding borehole location reserves subsurface reservoirs. However, important logs often missing in horizontal or old wells, which poses a challenge field applications. To address this issue, conventional methods involve supplementing by either combining geological experience referring data from nearby boreholes reconstructing them directly using remaining same borehole....
Logs are valuable information for oil and gas fields as they help to determine the lithology of formations surrounding borehole location reserves subsurface reservoirs. However, important logs often missing in horizontal or old wells, which poses a challenge field applications. In this paper, we utilize data from 2020 machine learning competition SPWLA, aims predict compressional wave slowness shear using other same borehole. We employ NGBoost algorithm construct an Ensemble Learning model...