A5029800838- Developmental Biology and Gene Regulation
- Congenital heart defects research
- Ichthyology and Marine Biology
- Paleontology and Evolutionary Biology
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- dental development and anomalies
- Hedgehog Signaling Pathway Studies
- Craniofacial Disorders and Treatments
- Marine Ecology and Invasive Species
- Evolution and Paleontology Studies
- Animal Genetics and Reproduction
- Marine animal studies overview
- Genomics and Phylogenetic Studies
- Axon Guidance and Neuronal Signaling
- Zebrafish Biomedical Research Applications
- Chromosomal and Genetic Variations
- Morphological variations and asymmetry
- Genetic diversity and population structure
- Physiological and biochemical adaptations
- Turtle Biology and Conservation
- Fish Ecology and Management Studies
- Congenital Ear and Nasal Anomalies
- Marine Invertebrate Physiology and Ecology
- Genetics and Physical Performance
- Cephalopods and Marine Biology
Pioneer (Japan)
2018-2024
RIKEN Center for Biosystems Dynamics Research
2012-2023
RIKEN
2003-2022
Morpho (United States)
2007-2019
Pioneer (United States)
2019
University of Copenhagen
2015
Kobe University
2013
Max Planck Institute for Ornithology
2011
Princeton University
2011
Monmouth College
2011
The anterior part of the vertebrate head expresses a group homeo box genes in segmentally restricted patterns during embryogenesis. Among these, Otx2 expression covers entire fore- and midbrains takes place earliest. To examine its role development rostral head, mutation was introduced into this locus. homozygous mutants did not develop structures to rhombomere 3, indicating an essential formation head. In contrast, heterozygous displayed craniofacial malformations designated as otocephaly;...
ABSTRACT The homeobox gene Emx2 is a mouse homologue of Drosophila head gap empty spiracles (ems) and essential for the development dorsal telencephalon (Yoshida, M., Suda, Y., Matsuo, I., Miyamoto, N., Takeda, Kuratani, S. Aizawa, (1997)Development 124, 101-111). At same time, expressed in epithelial components developing urogenital system and, mutant mice, kidneys, ureters, gonads genital tracts were completely missing. Pax-2 c-ret expressions Wolffian duct WT-1 GDNF metanephric blastema...
The unique anatomical features of turtles have raised unanswered questions about the origin their body plan. We generated and analyzed draft genomes soft-shell turtle (Pelodiscus sinensis) green sea (Chelonia mydas); our results indicated close relationship to bird-crocodilian lineage, from which they split ∼267.9-248.3 million years ago (Upper Permian Triassic). also found extensive expansion olfactory receptor genes in these turtles. Embryonic gene expression analysis identified an...
One of the central issues in evolutionary developmental biology is how we can formulate relationships between and processes. Two major models have been proposed: 'funnel-like' model, which earliest embryo shows most conserved morphological pattern, followed by diversifying later stages, 'hourglass' constraints are imposed to conserve organogenesis called phylotypic period. Here perform a quantitative comparative transcriptome analysis several model vertebrate embryos show that pharyngula...
Two rounds of whole-genome duplications are thought to have played an important role in the establishment gene repertoires vertebrates. These events occurred during chordate evolution after split urochordate and cephalochordate lineages but before radiation extant gnathostomes (jawed vertebrates). During this interval, diverse agnathans (jawless fishes), including cyclostomes (hagfishes lampreys), diverged. However, there is no solid evidence for timing these genome relation divergence from...
Modern cartilaginous fishes are divided into elasmobranchs (sharks, rays and skates) chimaeras, the lack of established whole-genome sequences for former has prevented our understanding early vertebrate evolution unique phenotypes elasmobranchs. Here we present de novo assemblies brownbanded bamboo shark cloudy catshark an improved assembly whale genome. These relatively large genomes (3.8-6.7 Gbp) contain sparse distributions coding genes regulatory elements exhibit reduced molecular...
Polyploidy or whole-genome duplication (WGD) is a major event that drastically reshapes genome architecture and often assumed to be causally associated with organismal innovations radiations. The 2R hypothesis suggests two WGD events (1R 2R) occurred during early vertebrate evolution. However, the timing of relative divergence gnathostomes (jawed vertebrates) cyclostomes (jawless hagfishes lampreys) unresolved whether these underlie phenotypic diversification remains elusive. Here we present...
ABSTRACT The genes Emx1 and Emx2 are mouse cognates of a Drosophila head gap gene, empty spiracles, their expression patterns have suggested involvement in regional patterning the forebrain. To define functions we introduced mutations into these loci. newborn mutants displayed defects archipallium structures that believed to play essential roles learning, memory behavior: dentate gyrus was missing, hippocampus medial limbic cortex were greatly reduced size. In contrast, subtle adult mutant...
Developmental constraints refer to biases that limit phenotypic changes during evolution. To examine the contribution of developmental in evolution vertebrate morphology, we analyzed distribution pattern mammalian vertebral formulae. Data on formulae were collected from Descriptive Catalogue Osteological Series Contained Museum Royal College Surgeons England by Richard Owen (1853) and plotted onto most reliable phylogenetic tree based recent molecular studies. In addition number cervical...
ABSTRACT Pax-6 is a member of the vertebrate Pax gene family, which structurally related to Drosophila pair-rule gene, paired. In mammals, expressed in several discrete domains developing CNS and has been implicated neural development, although its precise role remains elusive. We found novel Small eye rat strain (rSey2) with phenotypes similar mouse eye. Analyses revealed one base (C) insertion an exon encoding region downstream paired box resulting generation truncated protein due frame...
The Cyclostomata consists of the two orders Myxiniformes (hagfishes) and Petromyzoniformes (lampreys), its monophyly has been unequivocally supported by recent molecular phylogenetic studies. Under this updated vertebrate phylogeny, we performed in silico evolutionary analyses using currently available cDNA sequences cyclostomes. We first calculated GC-content at four-fold degenerate sites (GC4), which revealed that an extremely high is shared all lamprey species surveyed, whereas no...
The Pax6 gene plays a developmental role in various metazoans as the master regulatory for eye patterning. is also spatially regulated particular regions of neural tube. Because amphioxus has no neuromeres, an understanding expression agnathans crucial insight into origin neuromerism vertebrates. We have isolated single cognate cDNA gene, LjPax6, from Lampetra japonica library and observed pattern its using situ hybridization. Phylogenetic analysis revealed that LjPax6 occurs sister group...
Comparative genome analysis of non-avian reptiles and amphibians provides important clues about the process evolution in tetrapods. However, there is still only limited information available on structures these organisms. Consequently, protokaryotypes amniotes tetrapods evolutionary processes microchromosomes remain poorly understood. We constructed chromosome maps functional genes for Chinese soft-shelled turtle (Pelodiscus sinensis), Siamese crocodile (Crocodylus siamensis), Western clawed...
Genes involved in late specification of the mandibular arch, source vertebrate jaw, are expressed with similar patterns oral regions chick and lamprey embryos. However, morphological comparisons indicate that apparently orthologous homeobox genes were different subdivisions ectomesenchyme two species. Therefore, homology gene expression region uncoupled during transition from agnathan to gnathostome; we conclude a heterotopic shift tissue interaction was evolution jaw.
Chicken ovalbumin upstream promoter-transcription factor (COUP-TF) genes encode transcription factors belonging to the orphan subfamily of steroid/thyroid hormone receptor superfamily. Two COUP-TF counterparts have been cloned from mouse. In an attempt study function these in developing central nervous system (CNS), spatiotemporal expression patterns two mouse examined by situ hybridization. Both are widely expressed CNS, with that overlapping yet distinct each other. The differential murine...