A5083687563- Developmental Biology and Gene Regulation
- Axon Guidance and Neuronal Signaling
- Fatigue and fracture mechanics
- Ichthyology and Marine Biology
- Zebrafish Biomedical Research Applications
- Microstructure and Mechanical Properties of Steels
- Congenital heart defects research
- Optical measurement and interference techniques
- Environmental Toxicology and Ecotoxicology
- Semiconductor Lasers and Optical Devices
- Engineering Applied Research
- Structural Load-Bearing Analysis
- Welding Techniques and Residual Stresses
- Photonic and Optical Devices
- Neurogenesis and neuroplasticity mechanisms
- Advanced Measurement and Metrology Techniques
- Toxic Organic Pollutants Impact
- Paleontology and Evolutionary Biology
- Advanced Fiber Optic Sensors
- Laser and Thermal Forming Techniques
- Metal Forming Simulation Techniques
- Digital Radiography and Breast Imaging
- Aquaculture disease management and microbiota
- Fire effects on concrete materials
- Advanced Measurement and Detection Methods
Ehime University
2012-2023
Sumitomo Electric Industries (Japan)
1986-2019
Sumitomo Electric Industries (United States)
1991-2015
Honda (United States)
2013
RIKEN Center for Biosystems Dynamics Research
2003-2012
Friedrich Miescher Institute
2012
Okayama University of Science
2008-2009
École Normale Supérieure - PSL
2006
Inserm
2005-2006
Centre National de la Recherche Scientifique
2005-2006
Class 1 and 3 semaphorins repulse axons but bind to different cell surface proteins. We find that the two known semaphorin-binding proteins, plexin (Plex 1) neuropilin-1 (NP-1), form a stable complex. Plex alone does not semaphorin-3A (Sema3A), NP-1/Plex complex has higher affinity for Sema3A than NP-1 alone. While binding alter nonneuronal morphology, interaction with complexes induces adherent cells round up. Expression of dominant-negative in sensory neurons blocks Sema3A-induced growth...
The Pax6 gene plays a developmental role in various metazoans as the master regulatory for eye patterning. is also spatially regulated particular regions of neural tube. Because amphioxus has no neuromeres, an understanding expression agnathans crucial insight into origin neuromerism vertebrates. We have isolated single cognate cDNA gene, LjPax6, from Lampetra japonica library and observed pattern its using situ hybridization. Phylogenetic analysis revealed that LjPax6 occurs sister group...
Comparative genome analysis of non-avian reptiles and amphibians provides important clues about the process evolution in tetrapods. However, there is still only limited information available on structures these organisms. Consequently, protokaryotypes amniotes tetrapods evolutionary processes microchromosomes remain poorly understood. We constructed chromosome maps functional genes for Chinese soft-shelled turtle (Pelodiscus sinensis), Siamese crocodile (Crocodylus siamensis), Western clawed...
Genes involved in late specification of the mandibular arch, source vertebrate jaw, are expressed with similar patterns oral regions chick and lamprey embryos. However, morphological comparisons indicate that apparently orthologous homeobox genes were different subdivisions ectomesenchyme two species. Therefore, homology gene expression region uncoupled during transition from agnathan to gnathostome; we conclude a heterotopic shift tissue interaction was evolution jaw.
In the mouse trigeminal pathway, sensory inputs from distinct facial structures, such as whiskers or lower jaw and lip, are topographically mapped onto somatosensory cortex through relay stations in thalamus hindbrain. developing hindbrain, mechanisms generating maps remain elusive. We found that principal nucleus, whisker-related map is contributed by rhombomere 3–derived neurons, whereas 2–derived progeny supply lip representation. Moreover, early Hoxa2 expression neuroepithelium prevents...
A novel multi-core fiber (MCF), having eight cores within a 125-μm-diameter cladding and suitable for short-reach transmissions, is proposed. By optimizing O-band transmission, the proposed MCF realized high-density core packing simultaneously achieving optical characteristics comparable to those of standard single-mode in O-band, where low material dispersion can be leveraged. The compatible with conventional cabling/connecting technologies has tightly bendable mechanical reliability proven...
During development, the vertebrate hindbrain is subdivided along its anteroposterior axis into a series of segmental bulges called rhombomeres. These segments in turn generate repeated pattern rhombomere-specific neurons, including reticular and branchiomotor neurons. In amphioxus (Cephalochordata), sister group vertebrates, bona fide segmented lacking, although embryonic brain vesicle shows molecular regionalization. Therefore, evaluation patterning central nervous system agnathan embryos...
Plexins comprise a family of transmembrane proteins (the plexin family) which are expressed in nervous tissues. Some plexins have been shown to interact directly with secreted or semaphorins, while belonging the A subfamily suggested make complexes other membrane proteins, neuropilins, and propagate chemorepulsive signals semaphorins class 3 into cells neurons. Despite that much information has gathered on plexin-semaphorin interaction, role system is not well understood. To gain insight...
Neuropilin-1 is a type 1 membrane protein with three distinct functions. First, it can mediate cell adhesion via heterophilic molecular interaction. Second, in neuronal cells, neuropilin-1 binds the class 3 semaphorins, which are chemorepellents, and plays role directional guidance of axons. expected to form complexes plexinA subfamily members semaphorin-elicited inhibitory signals into neurons. Third, endothelial potent mitogen, vascular growth factor (VEGF)(165), regulates vessel...
Dorsoventral (DV) specification is a crucial step for the development of vertebrate telencephalon. Clarifying origin this mechanism will lead to better understanding central nervous system (CNS) evolution. Based on lamprey, sister group gnathostomes (jawed vertebrates), we identified three lamprey Hedgehog (Hh) homologues, which are thought play signalling roles in telencephalon patterning. However, unlike gnathostomes, none these genes, nor Lhx6/7/8, marker migrating interneuron subtype,...
The amplification of distinct neural stem/progenitor cell subtypes during embryogenesis is essential for the intricate brain structures present in various vertebrate species. For example, both mammals and birds, proliferative neuronal progenitors transiently appear on basal side ventricular zone telencephalon (basal progenitors), where they contribute to enlargement neocortex its homologous structures. In placental mammals, this population can be subdivided into several groups that include...
Vertebrates are equipped with so-called camera eyes, which provide them image-forming vision. Vertebrate vision evolved independently from that of other animals and is regarded as a key innovation for enhancing predatory ability ecological success. Evolutionary changes in the neural circuits, particularly visual center, were central acquisition However, evolutionary steps, protochordates to jaw-less primitive vertebrates then jawed vertebrates, remain largely unknown. To bridge this gap, we...
Abstract Agnathan cognates of vertebrate homeobox genes, Emx and Dlx , were isolated from embryonic cDNA a Japanese marine lamprey, Lampetra japonica . Analyses amino acid sequences indicated that the cognate was closely related to common ancestor gnathostome Dlx1 Dlx6 groups termed LjDlx1/6 Southern blot analyses could not rule out possibility L. possesses more than one paralog for both LjEmx lamprey Expression regulated spatially as well developmentally, its transcripts mainly found in...
Abstract In gnathostomes, the adenohypophysis, a component of hypothalamo‐hypophysial complex, is believed to develop through hierarchically organized epigenetic interactions based primarily on topographical relationships between tissues. From comparison developmental processes and gene expression patterns pituitary‐related genes agnathan species, lampreys we speculate evolutionary pathway vertebrate adenohypophysis. lamprey, this derived from nasohypophysial placode (NHP) that develops...