A5100764565- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Liver Disease Diagnosis and Treatment
- Congenital Anomalies and Fetal Surgery
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Iron Metabolism and Disorders
- Organ Donation and Transplantation
- Pediatric Hepatobiliary Diseases and Treatments
- Esophageal and GI Pathology
- Advanced Machining and Optimization Techniques
- Hepatocellular Carcinoma Treatment and Prognosis
- Hemoglobinopathies and Related Disorders
- Urological Disorders and Treatments
- Nutrition and Health in Aging
- Advanced machining processes and optimization
- Congenital Diaphragmatic Hernia Studies
- Gastrointestinal disorders and treatments
- Erythropoietin and Anemia Treatment
- Tracheal and airway disorders
- Lipoproteins and Cardiovascular Health
- Advanced Surface Polishing Techniques
- Intestinal Malrotation and Obstruction Disorders
- Teratomas and Epidermoid Cysts
- Vascular Malformations and Hemangiomas
Mie University
2011-2024
Fukushima Medical University Hospital
2018-2024
Tosei General Hospital
2024
Showa University Hospital
2024
University of California, San Diego
2023
Shonan Institute of Technology
2017-2021
University of Tsukuba
2014-2018
Dokkyo Medical University
2008-2015
National Center For Child Health and Development
2003-2015
Kyushu University
1999-2015
The resistance of parathyroid cells to 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) in uremic hyperparathyroidism is thought be caused, part, by a 1,25(OH)2D3 receptor (VDR) deficiency the parathyroids. However, results biochemical studies addressing VDR numbers parathyroids are controversial. Several have found content decreased patients and animals, while others no such decrease animals. To clarify role VDR, we investigated distribution surgically-excised obtained from chronic dialysis...
Patients with chronic hepatitis C frequently have serum and hepatic iron overload, but the mechanism is unknown. Recently identified hepcidin, exclusively synthesized in liver, thought to be a key regulator for homeostasis induced by infection inflammation. This study was conducted determine hepcidin expression levels patients various liver diseases. We investigated mRNA of samples real-time detection-polymerase chain reaction; 56 were virus (HCV) positive, 34 B (HBV) 42 negative HCV HBV (3...
Summary. 8‐Hydroxydeoxyguanosine (8‐OHdG) is a promutagenic DNA lesion produced by hydroxyl radicals and recognized as useful marker in estimating damage induced oxidative stress. The aim of this study was to clarify the clinical significance hepatic 8‐OHdG levels patients with chronic viral hepatitis. Hepatic accumulation investigated hepatitis C (CH‐C) ( n = 77) B (CH‐B) 34) immunohistochemical staining liver biopsy samples. positive hepatocytes were significantly higher CH‐C compared CH‐B...
Liver iron accumulation in patients with chronic hepatitis C (CHC) has received increasing attention recent years. The aim of this study was to determine the prevalence and severity liver deposition CHC, assess its relationship clinical, biochemical histological characteristics, influence on response interferon (IFN) plus ribavirin combination therapy.We studied biopsy specimens from 103 virus (HCV) 34 B (HBV) infected total score (TIS) measured. Seventy HCV genotype 1b were treated...
Visceral fat obesity plays an essential role in the clustering of atherosclerotic multiple risk factors metabolic syndrome. Telmisartan, angiotensin II type 1 receptor blocker, has partial agonistic properties for peroxisome proliferator-activated gamma, which is a key regulator adipocyte differentiation and function.This study aimed to clarify impact telmisartan on distribution insulin sensitivity In this open-label, prospective, randomized study, patients with syndrome (waist...
Several lines of evidence have suggested that oxidative stress plays an important role for the pathogenesis nonalcoholic steatohepatitis (NASH). Therefore, by using immunohistochemical staining liver biopsy samples, we measured hepatic 7,8-dihydro-8-oxo-2' deoxyguanosine (8-oxodG), a DNA base-modified product generated hydroxyl radicals, 38 NASH patients and compared with 24 simple steatosis 10 healthy subjects. Relation 8-oxodG clinical, biochemical, histologic variables changes after iron...
Brown rice (BR) and white (WR) produce different glycaemic responses their consumption may affect the dietary management of obesity. In present study, effects BR WR on abdominal fat distribution, metabolic parameters endothelial function were evaluated in subjects with syndrome a randomised cross-over fashion. study 1, acute postprandial flow- nitroglycerine-mediated dilation (FMD NMD) brachial artery determined male volunteers or without after ingestion either WR. The increases glucose...
Long-term supplementation with branched-chain amino acids (BCAA) is associated prolonged survival and decreased frequency of development hepatocellular carcinoma (HCC) in patients liver cirrhosis. However, the pharmaceutical mechanism underlying this association still unclear. We investigated whether continuous BCAA increases rate rats exposed to a fibrogenic agent influences iron accumulation, oxidative stress, fibrosis, gluconeogenesis liver. Further, effects on cultured cells were also...
Recently, chronic hepatitis E has been increasingly reported in organ transplant recipients European countries. In Japan, the prevalence of virus (HEV) infection after transplantation remains unclear, so we conducted a nationwide cross-sectional study to clarify HEV Japanese liver recipients.A total 1893 17 university hospitals Japan were examined for presence immunoglobulin G (IgG), IgM and IgA classes anti-HEV antibodies, RNA serum.The IgG, class antibodies was 2.9% (54/1893), 0.05%...
Endoplasmic reticulum (ER) stress is profoundly involved in dysfunction of β-cells under high-fat diet and hyperglycemia. Our recent study mice showed that γ-oryzanol, a unique component brown rice, acts as chemical chaperone the hypothalamus improves feeding behavior diet-induced dysmetabolism. However, entire mechanism whereby γ-oryzanol glucose metabolism throughout body still remains unclear. In this context, we tested whether reduces ER function survival pancreatic using murine β-cell...
Pemafibrate is a selective peroxisome proliferator-activated receptor α modulator that improves serum alanine aminotransferase (ALT) in dyslipidemia patients. was reported to reduce ALT non-alcoholic fatty liver disease (NAFLD) patients, but efficacy not clearly elucidated due the small size of previous study populations. Therefore, we explored pemafibrate NAFLD patients.We retrospectively evaluated on enzymes (n = 132) and shear wave velocity (SWV, n 51) patients who had taken for at least...
Autoantibodies (Abs) to steroid 21-hydroxylase (21-OH) are a major component of adrenal cortex Abs and characteristic autoimmune Addison's disease. We have developed new method for measuring 21-OH based on 125I-labeled recombinant human produced in yeast. With this assay, were detected 43 60 (72%) sera from patients with isolated disease, 11 12 (92%) polyglandular syndrome type I sera, 27 (100%) II 24 30 (80%) who positive antibodies by immunofluorescence but had no overt found 125I assay 4...
Minimal hepatic encephalopathy (HE) is associated with poorer quality of life and increased work disability. Recently, low-grade cerebral edema has been implicated in chronic liver disease.We measured the apparent diffusion coefficient (ADC) water various regions brains patients cirrhosis, elucidated significance evaluation ADC quantifying HE predicting overt survival. Forty cirrhosis 24 controls underwent diffusion-weighted imaging, were followed up every month.The mean values cirrhotic...
Background In the setting of liver transplantation in small infants who receive left lateral segment (LLS) grafts, problems are encountered related to graft-size mismatching form so-called “large-for-size” grafts. To address these problems, feasibility further reducing size LLS grafts hyperreduced (HRLLS) was investigated. Methods Of 175 pediatric living-donor transplantations performed between November 2005 and December 2011 at our institute, 31 cases were using HRLLS The medical records...
Objective Non-alcoholic fatty liver disease (NAFLD) is frequently associated with obesity, dyslipidemia and type-2 diabetes mellitus. Bile acids (BAs) bind to the farnesoid X receptor (FXR) G protein-coupled 5 (TGR5), which are involved in lipid glucose metabolism energy expenditure. The present study aimed determine associations between circulating BAs skeletal muscle volume (SMV), patients NAFLD. Methods Serum metabolic parameters were measured 55 NAFLD (median age, years). changes (Δ)...