A5101757205- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Digestive system and related health
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Cancer-related gene regulation
- Chromosomal and Genetic Variations
- Genomics and Phylogenetic Studies
- Gastrointestinal disorders and treatments
- Pancreatic function and diabetes
- Genetic diversity and population structure
- Peptidase Inhibition and Analysis
- Epigenetics and DNA Methylation
- Tracheal and airway disorders
- Wnt/β-catenin signaling in development and cancer
- Diet, Metabolism, and Disease
- Glutathione Transferases and Polymorphisms
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- HER2/EGFR in Cancer Research
- Microbial Metabolic Engineering and Bioproduction
- Organ Transplantation Techniques and Outcomes
- RNA Research and Splicing
- Medical Imaging Techniques and Applications
National Center for Global Health and Medicine
2015-2024
Juntendo University
2019-2024
Hokkaido University
1997-2022
Center for Global Health
2015-2022
Japan Society for the Promotion of Science
2020
Kagoshima University
2015-2018
Kanagawa Cancer Center
2017
Kanagawa Prefectural Hospital Organization
2017
Japanese Foundation For Cancer Research
2003-2016
The Cancer Institute Hospital
2003-2014
All snake species exhibit genetic sex determination with the ZZ/ZW type of chromosomes. To investigate origin and evolution chromosomes, we constructed, by FISH, a cytogenetic map Japanese four-striped rat (Elaphe quadrivirgata) 109 cDNA clones. Eleven clones were localized to Z chromosome. human chicken homologues Z-linked genes located on autosomes, suggesting that chromosomes snakes, mammals, birds all derived from different autosomal pairs common ancestor. We mapped 11 E. quadrivirgata...
Classification and concepts of the genera coryneform bacteria were described on basis results obtained previously. Coryneform divided into seven groups at generic level by combination mode cell division, principal amino acid in wall, guanine- cytosine content (GC content) DNA, biochemical physiological characteristics. The several made clearly a new genus Curtobacterium was proposed. scheme for differentiation these presented, problems classification discussed.
Toll-like receptors (TLR) in the innate immune system have not been identified non-mammalian vertebrates. Two types of <i>TLR</i> were cloned from a chicken bursa cDNA library using degenerate primers based on consensus sequences mouse and Drosophila Toll designated as <i>TLR</i>(<i>chTLR</i>) type 1 2. Of nine human TLRs reported to date, these chTLRs showed highest homology TLR2. The extracellular regions 2 contained distinct ∼200-amino acid stretch 45.3 46.3% homologous that intracellular...
To assess the risk of subsequent malignancies after esophagectomy for squamous cell carcinoma thoracic esophagus establishment an adequate follow-up program.We statistically analyzed clinical factors in 114 cases second malignancy that developed 94 679 patients who underwent curative resection. The cancer incidence rates general population estimated by Research Group Population-Based Cancer Registration Japan were used as standards comparison.The 10-year cumulative was 34.5%, and overall...
The DNA base composition (GC content) of 114 strains belonging to the so-called coryneform bacteria was examined from viewpoint bacterial taxonomy. GC content these ranged widely 46 78%. Although Cellulomonas fell into a relatively narrow range near 72%, those Corynebacterium, Arthrobacter, Microbacterium, and Brevibacterium did not exhibit specific characterize genus. This fact probably shows that genera bacteria, except Cellulomonas, are taxonomically heterogeneous. A new method for...
The composition of cell wall was studied on 112 strains coryneform bacteria. Strains named for the same genus did not always exhibit specific wall. However, tested bacteria were divided into three groups by presence each DL- and LL-diaminopimelic acid (DAP), lysine in wall, group demonstrated a common taxonomic characteristic. From this fact, principal amino acids, i.e., DL-DAP, LL-DAP, considered to indicate significance
Surgery for esophageal carcinoma is known to be associated with high morbidity. Recent studies have reported a correlation of nutritional and inflammatory parameters postoperative course. This study aims clarify the risk factors operative morbidity after resection carcinoma. Consecutive patients who underwent esophagectomy squamous cell at our institute were included (n = 102; 89 males 13 females; mean age: 67.3 years). Clinicopathological characteristics, presence or absence sarcopenia,...
Three glutamic-acid-producing coryneform strains were isolated from soil and vegetable samples. Chemotaxonomic investigations indicated that these belonged to the genus Corynebacterium. Phylogenetic studies, based on 16S rDNA analysis, demonstrated three formed a distinct cluster within Corynebacterium their nearest relatives glutamicum callunae, also known as species. The data sequence DNA-DNA relatedness studies clearly isolates represented new species All of could grow at 45 degrees C...
BSF-2 (B cell stimulatory factor-2/IL-6) is a member of the lymphokine family and responsible for B differentiation. Expression plasmids human cDNA were constructed using trp promotor/operator trpA terminator. In an extract Escherichia coli HB101 holding "direct" expression plasmid pBSF-2D, activity was detected, but overproduction not observed. A "fused" system therefore developed to prepare recombinant protein. this system, expressed as fused protein with IL-2 N-terminal peptide. case...
Phospholipid compositions were radiochemically studied on nocardioform and coryneform bacteria. Phosphatidylethanolamine (PE) was present in the strains of genera Corynebacterium, Nocardia, Mycobacterium. Cardiolipin phosphatidylglycerol found all tested. Sugar-containing phospholipids such as phosphatidyl-inositolmannosides phosphatidylinositol about half The Corynebacterium divided into two sub-groups by phospholipid composition. having a high GC-content exhibited presence large amount PE...
The bioavailability of newly developed sugar substitutes was observed by measuring the transmural potential difference (delta PD) evoked Na+-dependent active transport glucose, which is supposed to be produced hydrolysis substitutes. delta PD measured using everted intestinal sac prepared from jejunum adult rats and compared with digestibility in mucosal homogenate sac. PDs maltose or maltosylfructose had almost same levels, however, sucrose a little lower. maltitol palatinose were low,...
Partially inbred miniature swine developed in this laboratory provide a unique preclinical large animal model for studying transplant tolerance. The importance of vivo T cell depletion establishing stable mixed hematopoietic chimerism using clinically relevant sublethal regimen has been well documented murine studies (1). Until now, the lack an effective cell-depleting reagent limited progress involving transplants.The CD3 immunotoxin, pCD3-CRM9, was prepared by conjugating our...