A5033294815- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Lung Cancer Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Metastasis and carcinoma case studies
- Cancer-related gene regulation
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Treatments and Studies
- Nutrition and Health in Aging
- Tracheal and airway disorders
- Cancer Immunotherapy and Biomarkers
- Gastrointestinal Tumor Research and Treatment
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Head and Neck Cancer Studies
- Cancer Genomics and Diagnostics
- Inflammatory Biomarkers in Disease Prognosis
- Cardiac, Anesthesia and Surgical Outcomes
- PI3K/AKT/mTOR signaling in cancer
Japanese Foundation For Cancer Research
2016-2025
The Cancer Institute Hospital
2016-2025
Kanagawa Cardiovascular and Respiratory Center
2024
Queen Mary Hospital
2024
The Japanese Society of Gastroenterological Surgery
2014-2023
Kumamoto University
2011-2022
Toho University
2020
Toho University Omori Medical Center
2020
Cancer Institute (WIA)
2020
Japan Society for the Promotion of Science
2019
Abstract BACKGROUND: Exosomes are 40‐nm to 100‐nm membrane vesicles that secreted by various cells, and they play a major role in cell‐cell communication. The objective of this study was clarify the significance levels microRNA exosomes extracted from sera patients with esophageal squamous cell cancer (ESCC). METHODS: authors isolated serum samples who had ESCC benign diseases without systemic inflammation. Total RNA purified exosomes, expression microRNA‐21 (miR‐21) were analyzed...
Fusobacterium nucleatum (F. nucleatum) is a component of the human microbiome that primarily inhabits oral cavity. It causes periodontal disease and has also been implicated in development cancers. Although there are several reports relationship between F. clinical outcome cancers, its prognostic significance esophageal cancer remains unclear.We quantified DNA 325 resected specimens by qPCR. Significant pathways nucleatum-positive tissues were identified Kyoto Encyclopedia Genes Genomes...
To determine whether prognostic nutritional index (PNI) affects clinical outcome through local immunity in esophageal cancers.PNI is an indicator of status and systemic immune competence, has attracted attention as a biomarker. Tumor-infiltrating lymphocytes (TILs) are specific histological feature human cancers, reflecting individual's immunological tumor response.Using nonbiased database 337 curatively resected we evaluated the relationship between PNI, TILs status, CD8 expression by...
Abstract Gastroesophageal adenocarcinoma (GEA) is a lethal disease where targeted therapies, even when guided by genomic biomarkers, have had limited efficacy. A potential reason for the failure of such therapies that profiling results could commonly differ between primary and metastatic tumors. To evaluate heterogeneity, we sequenced paired GEA synchronous lesions across multiple cohorts, finding extensive differences in alterations, including discrepancies potentially clinically relevant...
MicroRNAs are approximately 22 nucleotide noncoding RNA molecules that posttranscriptionally regulate gene expression. The aim of this study was (a) to determine a role microRNA-21 in esophageal squamous cell carcinoma and (b) elucidate the regulation programmed death 4 (PDCD4) by microRNA-21.MicroRNA-21 expression investigated 20 matched normal epitheliums carcinomas seven lines (TE6, TE8, TE10, TE11, TE12, TE14, KYSE30) TaqMan quantitative real-time PCR situ hybridization. To evaluate...
The prognostic nutritional index is reportedly related to postoperative outcomes.The aim of this study was elucidate the clinical importance in patients with colorectal cancer who were undergoing primary tumor resection.This a retrospective from single institution.This conducted at surgery service an academic teaching hospital.The 556 between March 2005 and August 2014 eligible for study.The preoperative calculated. Classification regression tree analysis performed determine cutoff value....
Objective: To investigate the relationship between postoperative complications and long-term survival in patients with surgically resected esophageal squamous cell carcinoma (ESCC). Summary Background Data: Esophagectomy is mainstay of curative treatment for ESCC; however, this complex procedure has high risks morbidity mortality. The impact on such remains controversial. Methods: This retrospective single institution study included 502 consecutive who had undergone resection ESCC. Cox...
Abstract This is the second half of English edition Japanese Classification Esophageal Cancer, 12th Edition that was published by Japan Society in 2022.
The prognosis for individuals diagnosed with hepatocellular carcinoma (HCC) remains poor because of the high frequency invasive tumor growth, intrahepatic spread, and extrahepatic metastasis. Here, we investigated role standard isoform CD44 (CD44s), a major adhesion molecule extracellular matrix cancer stem cell marker, in TGF-β-mediated mesenchymal phenotype HCC. We found that CD44s was dominant form mRNA expressed HCC cells. Overexpression promoted invasiveness increased expression...
In Brief Objective: To construct a risk model for total gastrectomy outcomes using nationwide Internet-based database. Background: Total is very common procedure in Japan. This among the most invasive gastrointestinal procedures and known to carry substantial surgical risks. Methods: The National Clinical Database was used retrieve records on more than 1,200,000 cases from 3500 hospitals 2011. After data cleanup, 20,011 1623 were analyzed performed between January 1, 2011, December 31,...
To examine the prognostic impact of programmed death ligand 1 (PD-L1) expression, tumor-infiltrating lymphocyte (TIL) status, and their combination in esophageal cancer.PD-L1 has garnered much attention for its roles tumor immunology as an immune-based therapeutic target. ensure a response to PD-L1 checkpoint inhibitor, new framework based on expression presence or absence TILs is required.Using nonbiased database 305 curatively resected cancers, we evaluated TIL status (cluster...
Cancer-associated fibroblasts (CAFs) are reportedly involved in invasion and metastasis several types of cancer, including gastric cancer (GC), through the stimulation CXCL12/CXCR4 signaling. However, mechanisms underlying these tumor-promoting effects not well understood, which limits potential to develop therapeutic targets against CAF-mediated CXCL12 expression was analyzed resected GC tissues from 110 patients by immunohistochemistry (IHC). We established primary cultures normal (NFs)...
Background Skeletal muscle depletion (sarcopenia) is closely associated with limited physical ability and high mortality. This study evaluated the prognostic significance of skeletal status before after chemotherapy in patients unresectable colorectal cancer (CRC). Methods We conducted a retrospective analysis 215 consecutive CRC who underwent systemic chemotherapy. cross-sectional area was measured by computed tomography. value mass rate change Results One-hundred-eighty-two met our...