A5015480910- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Sarcoma Diagnosis and Treatment
- Esophageal and GI Pathology
- Soft tissue tumor case studies
- Gastrointestinal Tumor Research and Treatment
- Tumors and Oncological Cases
- Cancer Immunotherapy and Biomarkers
- Metastasis and carcinoma case studies
- Extracellular vesicles in disease
- Lung Cancer Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Cell Adhesion Molecules Research
- Gastrointestinal disorders and treatments
- Alkaline Phosphatase Research Studies
- Nutrition and Health in Aging
- S100 Proteins and Annexins
- Colorectal Cancer Surgical Treatments
- Lung Cancer Treatments and Mutations
- Colorectal and Anal Carcinomas
- Cancer Cells and Metastasis
- Peptidase Inhibition and Analysis
- Prostate Cancer Treatment and Research
- Immune cells in cancer
- Urinary Tract Infections Management
Kumamoto University
2015-2025
Japanese Foundation For Cancer Research
2018-2022
Kumamoto Medical Center
2022
Japan Community Healthcare Organization
2022
The Cancer Institute Hospital
2006-2020
Kumamoto City Hospital
2013-2014
Saiseikai Kumamoto Hospital
2014
Kyushu University
2003-2011
Teikyo University
2011
University of Idaho
2011
In the tumor microenvironment, senescent non-malignant cells, including cancer-associated fibroblasts (CAFs), exhibit a secretory profile under stress conditions; this senescence-associated phenotype (SASP) leads to cancer progression and chemoresistance. However, role of CAFs in metastatic lesions molecular mechanism inflammation-related SASP induction are not well understood. We show that pro-inflammatory cytokine-driven EZH2 downregulation maintains by demethylating H3K27me3 marks...
Cancer-associated fibroblasts (CAFs) are reportedly involved in invasion and metastasis several types of cancer, including gastric cancer (GC), through the stimulation CXCL12/CXCR4 signaling. However, mechanisms underlying these tumor-promoting effects not well understood, which limits potential to develop therapeutic targets against CAF-mediated CXCL12 expression was analyzed resected GC tissues from 110 patients by immunohistochemistry (IHC). We established primary cultures normal (NFs)...
Extracellular vesicles (EV) from cancer-associated fibroblasts (CAF) are composed of diverse payloads. Although CAFs impact the aggressive characteristics gastric cancer cells, contribution CAF-EV to progression has not been elucidated. Here, we investigated molecular mechanism changes in induced by CAF-EV. CAF abundance tissues was associated with poor prognosis patients receiving chemotherapy. Moreover, tubular network formation and drug resistance cells extracellular matrix (ECM)....
Fusobacterium nucleatum (F. nucleatum) is a gut microbe implicated in gastrointestinal tumorigenesis. Predicting the chemotherapeutic response critical to developing personalised therapeutic strategies for oesophageal cancer patients. The present study investigated relationship between F. and resistance squamous cell carcinoma (ESCC).We examined chemotherapy 120 ESCC resected specimens 30 pre-treatment biopsy specimens. In vitro studies using lines co-culture assays further uncovered...
Abstract Excess stroma and cancer-associated fibroblasts (CAF) enhance cancer progression facilitate immune evasion. Insights into the mechanisms by which manipulates microenvironment could help improve treatment. Here, we aimed to elucidate potential approaches for stromal reprogramming improved immunotherapy. Platelet-derived growth factor C (PDGFC) D expression were significantly associated with a poor prognosis in patients gastric cancer, PDGF receptor beta (PDGFRβ) was predominantly...
A recent large-scale phase III study (the ToGA trial) demonstrated the significant efficacy of trastuzumab combined with chemotherapy in patients HER2-positive gastric cancer. Although has become a key drug cancer treatment, resistance breast to is major problem clinical practice. However, it unclear whether similar mechanisms are involved (GC). The aim current was identify novel micro-RNA (miR)/gene pathway that regulates sensitivity GC cells trastuzumab. We focused on F-box and WD repeat...
Abstract Background The predictive significance of programmed death ligand 1 (PD-L1) for (PD-1) inhibitors remains unclear in gastric cancer (GC) due to the dynamic alteration by treatments. We aimed elucidate effects trastuzumab (Tmab) on PD-L1 expression GC. Methods was evaluated multicolour flow cytometry analysis after co-culturing GG cell lines and immune cells with Tmab. IFN-γ co-culture experiments quantified. Immunohistochemistry (IHC) using clinical samples also performed confirm...
This study explored the clinical utility of CT radiomics-driven machine learning as a predictive marker for chemotherapy response in colorectal liver metastasis (CRLM) patients. We included 150 CRLM patients who underwent first-line doublet chemotherapy, dividing them into training cohort (n=112) and test (n=38). manually delineated three-dimensional tumor volumes, selecting largest measurement, using pretreatment portal-phase images extracted 107 radiomics features. Treatment was classified...
To elucidate the clinical value of mean corpuscular volume (MCV) for prognostic prediction in patients with esophageal cancer who underwent radical esophagectomy.High MCV is suggested to be relevant incidence and prognosis several malignancies. However, few studies investigating correlation between survival outcome have been conducted.This study included 570 esophagectomy April, 2005 December, 2017. Patients were divided into 2 groups according standard pretreatment MCV: normal (83-99 fL)...
Programmed death ligand 1 (PD-L1) expression as a predictive biomarker for programmed cell (PD-1) inhibitor efficacy in gastric cancer (GC) remains controversial. We hypothesised that the conflicting results may be due to inaccurate assessment of PD-L1 using biopsy samples. A total 191 patients with GC who received radical resection were enrolled. expressions and paired resected samples by immunohistochemistry staining compared according number biopsies. The numbers PD-L1-positive determined...
The clinical significance of circulating tumour cell (CTC) detection in gastrointestinal (GI) cancer remains controversial and the molecular biological characteristics CTCs are poorly understood. A total 87 patients with metastatic or recurrent GI were prospectively enrolled. Circulating cells their HER2 status assessed using CellSearch System. Among 62 CTC-positive cases, we found 22 discordant cases (35.5%). HER2-negative primary tumours, 17 54 developed HER2-positive CTCs. Five eight had...