A5101830928- Nerve injury and regeneration
- Vascular Malformations and Hemangiomas
- Reconstructive Facial Surgery Techniques
- Vascular Malformations Diagnosis and Treatment
- Nonmelanoma Skin Cancer Studies
- Reconstructive Surgery and Microvascular Techniques
- Ear and Head Tumors
- Nerve Injury and Rehabilitation
- Salivary Gland Tumors Diagnosis and Treatment
- Wound Healing and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Facial Nerve Paralysis Treatment and Research
- Facial Rejuvenation and Surgery Techniques
- Ear Surgery and Otitis Media
- Botulinum Toxin and Related Neurological Disorders
- Orthopedic Surgery and Rehabilitation
- Anorectal Disease Treatments and Outcomes
- Ocular Disorders and Treatments
- Angiogenesis and VEGF in Cancer
- Vascular Anomalies and Treatments
- Cutaneous Melanoma Detection and Management
- Dermatologic Treatments and Research
- Advanced Radiotherapy Techniques
- Pelvic floor disorders treatments
- Pressure Ulcer Prevention and Management
Yokohama City University Hospital
2023-2025
Yokohama City University
2023-2025
Juntendo University
2011-2025
Juntendo University Urayasu Hospital
2017-2025
Creative Commons
2016
Okazaki City Hospital
2015
Nagoya City University
2011-2014
Nagoya City University Hospital
2014
Takeda (Japan)
2009-2013
Osaka Medical and Pharmaceutical University
2012
Persistent inflammatory environment and abnormal macrophage activation are characteristics of chronic diabetic wounds. Here, we attempted to characterize the differences in temporal variations cytokine expression non-diabetic wounds, with a focus on interleukin (IL)-6 mRNA p38 MAPK PI3K/Akt signaling pathways. Cutaneous wound closure, CD68- arginase-1 (Arg-1)-expressing macrophages, were examined streptozotocin-induced type 1 mice at different time points after injury. The effect IL-6 Akt...
Abstract Objective: Sensory nerve grafts are often used to reconstruct injured motor nerves, but the consequences of such motor/sensory mismatches not well studied. nerves have more diverse fiber distributions than and may possess phenotypically distinct Schwann cells. Putative differences in cell characteristics pathway architecture negatively affect regeneration neurons down sensory pathways. We hypothesized that impair target reinnervation, thereby contributing suboptimal outcomes. This...
Background/Objectives: The therapeutic efficacy of percutaneous sclerotherapy (PS) for venous malformations (VMs) based on volumetric magnetic resonance imaging (MRI) measurements and its association with early post-treatment coagulation markers remains unexplored. This study evaluates the 5% monoethanolamine oleate (EO)-based PS in treating difficult-to-resect VMs using MRI investigates changes markers. Methods: post-hoc analysis utilized data from a prospective, open-label, multicenter...
To evaluate the effect and safety of sclerotherapy in patients with difficult-to-resect venous malformations treated ethanolamine oleate. This investigator-initiated clinical trial employed a multicenter, single-arm design was conducted Japan. Overall, 44 were categorized into two cohorts: 22 cystic-type diffuse-type malformations, including children (<15 years old). Adult received injections 5% oleate solution, double diluted contrast or normal saline, maximum dose 0.4 mL/kg. The same...
Levator aponeurosis advancement is one of the most well-known surgical procedures performed for blepharoptosis globally. Nevertheless, a patient’s condition at 6 months after surgery difficult to accurately predict before or during levator advancement. This study aimed determine which margin reflex distance (MRD) strongly correlates with MRD surgery. included 126 eyelids 63 patients who underwent bilateral aponeurotic acquired ptosis and were followed up >6 months. Frontal-view...
The efficacy, safety, and optimal concentration of topical sirolimus gel for treatment cutaneous lesions vascular anomalies requires evaluation. This study was a multicenter, double-blind, placebo-controlled, parallel-group, phase II randomized clinical trial. We enrolled patients with venous malformation (n = 27), lymphatic 14), tufted angioma 8), or kaposiform hemangioendothelioma 1). Patients applied either placebo 0.2% 0.4% to the target lesion twice per day 12 weeks. primary endpoint...
Recent evidence supports the use of end-to-side neurorrhaphy for treatment certain peripheral nerve disorders. However, mechanism by which nerves regenerate following this procedure is still unclear. To address question, authors designed a new coaptation model in rats donor were uninjured. The regenerated axons at site observed directly using fluorescent dye as neural tracer. sciatic from adult Wistar was transplanted between left and right median nerves. Fifteen divided into three groups....
Abstract With consideration of the ongoing developments in treatment options for cutaneous melanoma, Japanese Skin Cancer Society published first guidelines melanoma 2007 and later revised them 2015. Here, we report on an English version 2019 Melanoma Guidelines. In this latest edition, all processes were carried out according to Grading Recommendations, Assessment, Development Evaluation system. A comprehensive work search, systematic review determination recommendations each clinical...
Retrograde labeling has become an important method of evaluation for peripheral nerve regeneration after injury. We review the features commonly used retrograde tracers Fast Blue, Fluoro-Gold, and Fluoro Ruby in addition to various application methods (conduit reservoir, intramuscular injection, crystal powder application) techniques count stained neurons. Upon staining dyes a rat mouse injury model, Fluoro-Gold was found stain greatest number neurons with all methods. However, due...
End-to-side (ETS) nerve repair, in which the distal stump of a transected is coapted to side an uninjured donor nerve, offers technique for repair peripheral injuries where proximal unavailable or significant gap exists. Details animal models are explored including motor and sensory regeneration further clarify mechanism collateral sprouting while eliminating false positive results from contaminating axons. Some experimental studies support conclusion that reinnervation may be derived others...
The object of this report is to share our experience conservative management giant aplasia cutis congenita (ACC) the scalp with topical application basic fibroblast growth factor (bFGF). Complete epithelialization 9 × 8 cm sized defect was achieved in 33 weeks. Careful could eliminate requirement surgery for ACC defects bone and should be tried if thought risky or has consecutive morbidity. Topical bFGF seems accelerate healing, also providing a better epithelium later reconstructive...
The "Summary of Japanese clinical practice guidelines for Bell's palsy (idiopathic facial palsy) - 2023 update edited by the Japan Society Facial Nerve Research" aims to review latest evidence regarding treatment and provide appropriate recommendations.
Abstract Autologous endothelial progenitor cell (EPC) therapy is commonly used to stimulate angiogenesis in ischemic repair and wound healing. However, low total numbers functional deficits of EPCs make autologous EPC ineffective diabetes. Currently, no known ex vivo culture techniques can expand and/or ameliorate the for clinical usage. Recently, we showed that a quality-quantity (QQc) system restores vasculogenic wound-healing efficacy murine diabetic EPCs. To validate these results...
The authors have developed a technique for the treatment of facial paralysis that utilizes anastomosis split hypoglossal and nerve. Here, they document improvements in procedure experimental evidence supporting approach.They analyzed outcomes 36 patients who underwent procedure, all whom had suffered from following removal large vestibular schwannomas. average period was 6.2 months. used 5 different variations selecting nerve, including evaluation nerve using recordings evoked potentials...
The accurate diagnosis and treatment of posterior plagiocephaly have been a source controversy. unilateral lambdoid synostosis that is characterized by flattening ipsilateral occipital bone rare type craniosynostosis. An 8-month-old infant with reported. patient exhibited right flattening, mastoid bulge, frontal prominence, the auricle displaced anteroinferiorly on gross examination. A Towne projection radiograph skull three-dimensional computed tomography scans revealed suture was...
The clinical significance of circulating tumour cell (CTC) detection in gastrointestinal (GI) cancer remains controversial and the molecular biological characteristics CTCs are poorly understood. A total 87 patients with metastatic or recurrent GI were prospectively enrolled. Circulating cells their HER2 status assessed using CellSearch System. Among 62 CTC-positive cases, we found 22 discordant cases (35.5%). HER2-negative primary tumours, 17 54 developed HER2-positive CTCs. Five eight had...
The synthetic leukotriene B4 receptor type 2 (BLT2) agonist CAY10583 (CAY) accelerates wound healing in diabetic mice by promoting keratinocyte migration. However, its effects on fibroblast activity and granulation are unknown. We investigated the mechanisms which CAY promotes healing.CAY was applied to wounds streptozotocin-induced rats, closure, thickness, epithelialization gaps were analyzed. BLT2 expression examined RT-PCR. Migration proliferation studied scratch assays MTS assays....
Abstract The objective was to prepare guidelines perform the current optimum treatment by organizing effective and efficient treatments of hemangiomas vascular malformations, confirming safety, systematizing treatment, employing evidence-based medicine (EBM) techniques aimed at improvement outcomes. Clinical questions (CQs) were decided based on important clinical issues. For document retrieval, key words for literature searches set each CQ published from 1980 end September 2014 searched in...
Abstract The objective was to prepare guidelines perform the current optimum treatment by organizing effective and efficient treatments of hemangiomas vascular malformations, confirming safety, systematizing treatment, employing evidence‐based medicine (EBM) techniques aimed at improvement outcomes. Clinical questions (CQs) were decided based on important clinical issues. For document retrieval, key words for literature searches set each CQ published from 1980 end September 2014 searched in...
Abstract The objective was to prepare guidelines perform the current optimum treatment by organizing effective and efficient treatments of hemangiomas vascular malformations, confirming safety systematizing treatment, employing evidence‐based medicine techniques aimed at improvement outcomes. Clinical questions (CQ) were decided based on important clinical issues. For document retrieval, key words for published work searches set each CQ, from 1980 end September 2014 searched in PubMed,...
Glial cell line-derived neurotrophic factor (GDNF) has potent survival effects on central and peripheral nerve populations. The authors examined the differential of GDNF following either a sciatic crush injury in mice that overexpressed or nervous systems (glial fibrillary acidic protein [GFAP]-GDNF) muscle target (Myo-GDNF).Adult (GFAP-GDNF, Myo-GDNF, wild-type [WT] animals) underwent were evaluated using histomorphometry force power testing. Uninjured WT animals served as controls.In...