A5030188650- Nerve injury and regeneration
- Nerve Injury and Rehabilitation
- RNA Interference and Gene Delivery
- Tissue Engineering and Regenerative Medicine
- Organ and Tissue Transplantation Research
- Electrospun Nanofibers in Biomedical Applications
- Neurogenesis and neuroplasticity mechanisms
- Reconstructive Surgery and Microvascular Techniques
- Peripheral Nerve Disorders
- Signaling Pathways in Disease
- Neuroscience and Neural Engineering
- Surgical Sutures and Adhesives
- Pain Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Orthopedic Surgery and Rehabilitation
- Wound Healing and Treatments
- Spine and Intervertebral Disc Pathology
- Tendon Structure and Treatment
- Facial Nerve Paralysis Treatment and Research
- Birth, Development, and Health
- Anesthesia and Pain Management
- Nanoparticles: synthesis and applications
- Digital Imaging in Medicine
- Mesenchymal stem cell research
- Neuropeptides and Animal Physiology
Washington University in St. Louis
2015-2025
Check Point (Israel)
2022
University of Saint Louis
2022
The Ohio State University Wexner Medical Center
2021-2022
Walter Reed National Military Medical Center
2021
Creative Commons
2019
Georgia Southern University
2016-2018
Naval Medical Research Command
2017
Moore College of Art and Design
2016
Plastic Surgery Foundation
2014
Autografting is the gold standard in repair of peripheral nerve injuries that are not amenable to end-to-end coaptation. However, because autografts result donor-site defects and a limited resource, an effective substitute would be valuable. In rat model, we compared isografts with Integra NeuraGen (NG) guides, which commercially available type I collagen conduit, processed allografts comparable AxoGen's Avance human decellularized allograft product. 14-mm sciatic gap isograft was superior...
Alternatives to autografts have long been sought for use in bridging neural gaps. Many entubulation materials studied, although with generally disappointing results comparison autografts. The purpose of this study was design a more effective guidance conduit, introduce Schwann cells into the and determine regenerative capability through it an vivo model. A novel, fully biodegradable polymer conduit designed fabricated peripheral nerve repair, which approximates macro- microarchitecture...
This study reports a rat model of chronic nerve compression. The sciatic nerves adult male Sprague Dawley rats were banded with 1-cm lengths tubing varying internal diameters. Histological and electrical studies as well to assess the blood-nerve barrier function carried out at one through six months. With marked compression nerve, profound changes noted early month, histological findings those degeneration regeneration. In minimal compression, conduction remained normal. earliest alterations...
The effect of long-term denervation on neuromuscular recovery was studied in a rat hind limb model. posterior tibial nerve transected and repaired immediately or after periods 2 weeks, 1, 3, 6, 9, 12 months. Six months following reconstruction excellent axonal regeneration seen across all repairs irrespective denervation. However, there precipitous profound decrease the both muscle mass integrated motor function if delayed for longer than 1 month. Rather progressive change proportional to...
Processed nerve allografts offer a promising alternative to autografts in the surgical management of peripheral injuries where short deficits exist.Three established models acellular allograft (cold-preserved, detergent-processed, and AxoGen-processed allografts) were compared with isografts silicone guidance conduits 14-mm rat sciatic defect.All grafts superior support regeneration. Detergent-processed similar at 6 weeks postoperatively, whereas cold-preserved supported significantly fewer...
Mackinnon, Susan E. M. D., F. R. C. S.(C); Hudson, Alan B., Hunter, Daniel A. T.
Peripheral compression neuropathy is a common clinical entity but little human nerve material has been available for study. It difficult to develop an experimental model of chronic which reliable and reproducible, making it assess the various treatment modalities currently in use manage this problem. In recent study using rat model, connective tissue fiber changes associated with were described by authors. The present expands same multifascicular median cynomolgus monkey, test whether or not...
Compared to the nerve guidance conduits (NGCs) constructed from a single layer of aligned nanofibers, bilayer NGCs with random and nanofibers in outer inner layers are more robust tear-resistant during surgical procedures thanks an isotropic mechanical property provided by nanofibers. However, it remains unclear whether will interfere alter extension pattern neurites impede regeneration. To answer this question, we seeded dorsal root ganglia (DRG) on double-layered scaffold, top bottom...
This article describes a model of chronic nerve compression in the rat. The sciatic adult male Sprague Dawley rats was banded with 1-cm Silastic tube for varying periods time. Morphometric analysis, electrodiagnostic studies, and histological evaluation were carried out 3, 5, 8, 12 months after banding. Histological at 3 normal. At 5 perineurial thickening demonstrated. In periphery fascicles, segmental demyelination noted; central fibers appeared 8 there further epineurial thickening....
Mackinnon, Susan E. M.D., F.R.C.S.(C); Dellon, A. Lee M.D.; Hudson, Alan R. M.B., Hunter, Daniel R.T.
Lewis rats (RT1(1] were the recipients of 3-cm nerve grafts from syngeneic donors or allogeneic ACI (RT1a) donors. Microneurosurgical repair graft to transected sciatic recipient animal was performed with 10-0 epineurial sutures. Recipients randomly allocated cyclosporin A (CsA) immunosuppressed untreated groups. Cyclosporin administered in minimal effective dosage prevent allograft rejection across this major histocompatibility disparity (5 mg/kg per day). Nerve regeneration assessed by...