A5101978178- Congenital Diaphragmatic Hernia Studies
- Neuroblastoma Research and Treatments
- Congenital Anomalies and Fetal Surgery
- Organ Transplantation Techniques and Outcomes
- Congenital gastrointestinal and neural anomalies
- Pediatric Hepatobiliary Diseases and Treatments
- Liver Disease and Transplantation
- Intestinal Malrotation and Obstruction Disorders
- Gallbladder and Bile Duct Disorders
- Esophageal and GI Pathology
- Neonatal Respiratory Health Research
- Cancer, Hypoxia, and Metabolism
- Vascular Malformations and Hemangiomas
- Renal Transplantation Outcomes and Treatments
- Cancer, Lipids, and Metabolism
- Clinical Nutrition and Gastroenterology
- Tracheal and airway disorders
- Cancer therapeutics and mechanisms
- Tumors and Oncological Cases
- Gastrointestinal disorders and treatments
- Sarcoma Diagnosis and Treatment
- Urological Disorders and Treatments
- Pelvic floor disorders treatments
- Tuberous Sclerosis Complex Research
- Hepatocellular Carcinoma Treatment and Prognosis
Keio University
2016-2025
Japanese Urological Association
2024
Kanagawa Children's Medical Center
2023-2024
Japan Cancer Society
2024
Keio University Hospital
2014-2023
University of Hyogo
2023
Tohoku University
2021
East Asia School of Theology
2021
Ministry of Health Labour and Welfare
2018
National Hospital Organization
2008-2012
Background Complex lymphatic anomalies are intractable disorders, including generalized anomaly (GLA), Gorham–Stout disease (GSD), and kaposiform lymphangiomatosis (KLA). The etiology of these diseases remains unknown diagnosis is confused by their similar clinical findings. This study aimed to clarify the differences in features prognosis among GLA, KLA, GSD, Japanese patients. Procedure Clinical features, radiological pathological findings, treatment, patients were obtained from a...
Introduction Intractable lymphatic anomalies (LAs) include cystic malformation (LM; macrocystic, microcystic, or mixed), generalized anomaly, and Gorham–Stout disease. LAs can present with severe symptoms poor prognosis. Thus, prospective studies for treatments are warranted. We conducted a clinical trial of sirolimus intractable LAs. Methods This was an open-label, single-arm, multicenter, involving five institutions in Japan. All patients received oral once daily, the dose adjusted to...
Mullerian inhibiting substance (MIS) in the adult rat ovary can be detected by immunohistochemistry granulosa cells of growing preantral follicles and cumulus oophorus periluminal antral estrus, metestrus, diestrus, proestrus. Neither corpus luteum nor atreitic stained for MIS. During proestrus, dramatic changes occurred large preovulatory follicles, which early day manifest intense MIS-specific staining located close to oocyte, however, at 2300 h, just before ovulation when germinal vesicle...
Intractable vascular anomalies (VAs), including tumors and venous, lymphatic, mixed malformations, often have severe symptoms a poor prognosis, highlighting the need for new treatments. We conducted prospective trial of sirolimus (tablet granule forms) treatment VAs. In this open-label, single-arm, multicenter across four Japanese institutions, patients with VAs received oral daily, targeting trough concentration 5-15 ng/mL. evaluated response rates (radiological volume changes in lesions),...
Mullerian Inhibiting Substance (MIS) production in rat testes from the late fetal to adult period and its modulation by gonadotropins neonatal were studied using immunohistochemistry, northern analysis, a graded organ culture bioassay for MIS. The intense immunohistochemical staining MIS seen newborn began decrease gradually after third postnatal day, then decreased dramatically on fifth day. activity was present at low level until about 20th which it barely detectable. rats treated with FSH...
Mowat–Wilson syndrome (MWS) is a multiple congenital anomaly characterized by moderate or severe intellectual disability, characteristic facial appearance, microcephaly, epilepsy, agenesis hypoplasia of the corpus callosum, heart defects, Hirschsprung disease, and urogenital/renal anomalies. It caused de novo heterozygous loss function mutations including nonsense mutations, frameshift deletions in ZEB2 at 2q22. encodes zinc finger E‐box binding homeobox 2 protein consisting 1,214 amino...
Tumors comprise heterogeneous cell types including cancer stem cells (CSC), progenitor cells, and differentiated cells. Chemoresistance is a potential cause of relapse key characteristic CSC, but the development novel therapeutic approaches for targeting these has been limited. We previously established osteosarcoma-initiating (OSi) by introducing gene c-Myc into bone marrow stromal Ink4a/Arf knockout mice. These OSi are composed two distinct clones: highly tumorigenic (AX cells), similar to...
Lymphatic anomalies (LAs) refer to a group of diseases involving systemic dysplasia lymphatic vessels. These lesions are classified as cystic malformation (macrocystic, microcystic or mixed), generalized anomaly, and Gorham-Stout disease. LAs occur mainly in childhood, present with various symptoms including chronic airway problems, recurrent infection, organ disorders. Individuals often experience progressively worsening deteriorating quality life. Although limited treatment options...
Abstract Fetal female urogenital anomalies are often difficult to evaluate by ultrasonography, especially in late gestation. We report a case of fetal hydrometrocolpos detected at 35 weeks Ultrasonography revealed large retrovesical septate hypoechogenic mass the abdomen, however sonographic findings were inconclusive. Magnetic resonance imaging (MRI) confirmed that abdominal was fluid‐filled with mid‐plane septum midline posterior bladder, and showed connection dilated uterus duplicated....
Abstract Background Despite the presence of ganglion cells in rectum, some patients have symptoms similar to those Hirschsprung's disease. A consensus has yet be established regarding terminology for these diseases. We defined this group diseases as “allied disorders disease” and compiled guidelines facilitate accurate clinician diagnosis provide appropriate treatment strategies each Methods These were developed using methodologies Medical Information Network Distribution System ( MINDS )....
The curability of chemotherapy-resistant hepatoblastoma (HB) largely depends on the achievement radical surgical resection. Navigation techniques utilizing indocyanine green (ICG) are a powerful tool for detecting small metastatic lesions. We herein report patient who underwent second living donor liver transplantation (LDLTx) multiple recurrent HBs in graft following metastasectomy peritoneal dissemination with ICG navigation. initially presented ruptured HB at 6 years age and 3 resections...
Müllerian Inhibiting Substance (MIS) causes regression of the ducts during a critical period in embryonic development male mammals. In Persistent Duct Syndrome (PMDS), an autosomal recessive trait humans and dogs, fail to regress otherwise normal males. Previously we reported that PMDS-affected dogs produce bioactive testicular MIS postnatally. The purpose present study was determine whether canine embryos appropriately express mRNA protein for duct regression. Homozygous (PMDS-affected)...
Unplanned resection of a sarcoma is often chosen in the early phase by general physicians without any imaging scrutiny. The present study aimed to highlight clinical problems associated with unplanned sarcomas.Thirty-eight patients who underwent and additional treatment were examined. definite histological grading was high 31 low 7 patients.The tumors located depth subfascia 13 patients. maximal tumor sizes exceeded 5 cm 16 Preoperative MRI only performed six previous surgical margins...
Recently, liver transplantation (LT) has been increasingly performed for unresectable hepatoblastoma (HB) with acceptable results. We conducted a national survey of cases undergoing living donor (LDLT) HB to evaluate their outcomes. Thirty-nine patients (28 males and 11 females median age at LDLT 3.6 years) who had undergone by the end 2009 were enrolled in this study. The clinical data collected from medical records via questionnaire 2011 (median follow-up = 4.6 years). Thirteen (33.3%)...