A5063903375- Neuroblastoma Research and Treatments
- Congenital Anomalies and Fetal Surgery
- Renal and related cancers
- Organ Transplantation Techniques and Outcomes
- Pancreatic and Hepatic Oncology Research
- Liver Disease and Transplantation
- Pediatric Hepatobiliary Diseases and Treatments
- Neuroendocrine Tumor Research Advances
- Congenital gastrointestinal and neural anomalies
- Sarcoma Diagnosis and Treatment
- Vascular Malformations and Hemangiomas
- Testicular diseases and treatments
- Stoma care and complications
- Gallbladder and Bile Duct Disorders
- Pediatric Urology and Nephrology Studies
- Childhood Cancer Survivors' Quality of Life
- Urological Disorders and Treatments
- Hernia repair and management
- Glioma Diagnosis and Treatment
- Tumors and Oncological Cases
- Pancreatitis Pathology and Treatment
- Intestinal Malrotation and Obstruction Disorders
- Adrenal and Paraganglionic Tumors
- Neurofibromatosis and Schwannoma Cases
- Medical Imaging and Pathology Studies
Kyushu University
2015-2025
Japan Surgical Society
2024
Kyushu University Hospital
2022-2023
National Cancer Center Hospital East
2021
Society of Surgical Oncology
2021
National Cancer Center
2019-2020
National Center For Child Health and Development
2019
Children's Cancer Center
2019
Fukuoka Children's Hospital and Medical Center for Infectious Diseases
2014
Kitakyushu Municipal Medical Center
2012
Two cases of pediatric lung cancer (in 23-month-old and 6-year-old boys) resulting from mother-to-infant transmission uterine cervical tumors were incidentally detected during routine next-generation sequencing paired samples tumor normal tissue. Spontaneous regression some lesions in the first child slow growth mass second suggested existence alloimmune responses against transmitted tumors. Immune checkpoint inhibitor therapy with nivolumab led to a strong all remaining child. (Funded by...
Congenital mesoblastic nephromas (CMN) are histologically classified into classical, cellular, and mixed subtypes. Most cellular CMNs harbor ETV6-NTRK3 gene fusions, classic EGFR internal tandem duplications (EGFR-ITDs). Classic considered benign, whereas recurrent or metastatic diseases occur in the Direct identification of mutations is desirable for an accurate diagnosis. However, molecular genetic analyses cannot be performed a number histopathology laboratories. This study aimed to...
Purpose: This study assessed the long-term impact of bile leak complications on pediatric hepatoblastoma (HB) patients post-surgery. With HB predominantly affecting children under five, increased survival rates necessitate a focus post-surgical complications, particularly concerning effects leaks. Methods: A retrospective analysis was conducted treated for at our institution from 1980 to 2022. The diagnosis, operative procedure, mortality, and prognosis were retrospectively analyzed examine...
Intractable vascular anomalies (VAs), including tumors and venous, lymphatic, mixed malformations, often have severe symptoms a poor prognosis, highlighting the need for new treatments. We conducted prospective trial of sirolimus (tablet granule forms) treatment VAs. In this open-label, single-arm, multicenter across four Japanese institutions, patients with VAs received oral daily, targeting trough concentration 5-15 ng/mL. evaluated response rates (radiological volume changes in lesions),...
Severe obesity in young children prompts for a differential diagnosis that includes syndromic conditions. Rapid-Onset Obesity with Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation (ROHHAD) syndrome is potentially fatal disorder characterized by rapid-onset associated hypoventilation, neural crest tumors, endocrine behavioral abnormalities. The etiology of ROHHAD remains to be established, but recent research has been focusing on autoimmunity. We report 2-year-old girl...
Isolated hypoganglionosis (IHG) is histologically characterized by small numbers of myenteric ganglion cells and ganglia; however, no numerical diagnostic criteria for IHG have been established. Therefore, this study aimed to develop quantitative pathologic IHG. We evaluated 160 resected intestinal tissue specimens from 29 pediatric autopsies 10 cases. These were obtained the jejunum, ileum, ascending colon, transverse rectum. Morphologic features ganglia quantified analyzed in digitized...
BACKGROUND Pediatric pancreatic tumors are rare and account for < 0.1% of all childhood cancers. The primary treatment is surgical resection. However, because the lack knowledge regarding pediatric tumors, no comprehensive plans have been developed. AIM To compared clinical features, methods, prognosis in Japan with those other countries. METHODS Questionnaires were sent to 213 units Japan. Pancreatic that not surgically treated excluded from survey. survey investigated number patients...
Background: Thoracoscopic surgery for pediatric benign tumors is a common procedure. However, large incision needed to remove from the thoracic cavity. And, intrapulmonary sequestration in lower lobe, it sometimes needs ligate aberrant vessels. A muscle-sparing axillar skin crease (MSASCI) has been introduced open surgery, resulting excellent aesthetic outcomes compared with standard incision. We herein report utility of this MSASCI technique thoracoscopic cavity and vessels lobe. Materials...
Abstract Objective 123 I metaiodobenzylguanidine (MIBG) scintigraphy is a useful tool for the diagnosis of neuroblastoma (NB). MIBG uptake correlated with norepinephrine transporter expression; hence, it expected that high-MIBG tumors would be more highly differentiated and have better prognosis than those lower expression. We introduced method assessing accumulation semi-quantitatively using SPECT/CT fusion images. The purpose this study was to evaluate relationship measured by...
The mechanism underlying the spontaneous regression of neuroblastoma is unclear. Although it was hypothesized that this occurs via an immunological mechanism, there no clinical evidence, and animal models have been developed to investigate involvement immune systems, especially natural antibodies, against neuroblastoma. We performed analysis homo- heterozygous TH-MYCN transgenic mice as a model aggressive Mice with or small (<5 mm) tumors showed higher antibody titers in plasma than large...
Hepatoblastoma (HB) is the most common malignant liver tumor in childhood. Although pre-operative cisplatin (CDDP)-based chemotherapy often used cases of HB, about 20％ HB patients exhibit resistance to CDDP. Forkhead box protein M1 (FOXM1) and chromo-domain-helicase-DNA-binding 4 (CHD4) have been associated with CDDP various tumors. We here analyzed immunohistochemical expression FOXM1 CHD4 specimens 33 (mean age: 20 months) post-chemotherapy. The differentiation was assessed using digital...
Abstract Background Recently, reports of endoscopic approaches for neuroblastoma, ganglioneuroblastoma, and ganglioneuroma (peripheral neuroblastic tumor; PNTs) have been increasing. This study aimed to clarify the indications surgery PNTs. Methods Pediatric patients who underwent PNTs at our institution were included in this study. Image‐defined risk factors (IDRFs) analyzed using preoperative computed tomography (CT). Results Twenty‐four The diagnoses neuroblastoma ( n = 11), 10),...