A5070444406- Cancer Immunotherapy and Biomarkers
- Virus-based gene therapy research
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Ferroptosis and cancer prognosis
- Cancer Research and Treatments
- Lymphoma Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Cell Adhesion Molecules Research
- RNA Interference and Gene Delivery
- Gastric Cancer Management and Outcomes
- T-cell and B-cell Immunology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Treatments and Studies
- Gastrointestinal Tumor Research and Treatment
- interferon and immune responses
- Cancer, Stress, Anesthesia, and Immune Response
- Esophageal Cancer Research and Treatment
- Cytokine Signaling Pathways and Interactions
- Cancer, Hypoxia, and Metabolism
- Monoclonal and Polyclonal Antibodies Research
Kobe Children's Hospital
2022-2024
National Cancer Research Institute
1992-2024
Tokyo University of Science
1995-2024
Toranomon Hospital
2024
Saitama Cancer Center
2024
National Cancer Centre Japan
2003-2023
National Institutes for Quantum Science and Technology
2023
National Cancer Center Hospital East
2023
Hachinohe Gakuin University
2022
In-Q-Tel
2013
S100A8/A9, a proinflammatory protein, is upregulated in inflammatory diseases, and also has tumor-promoting activity by the recruitment of myeloid cells tumor cell invasion. However, whether expression S100A8/A9 tumors predicts good or poor prognosis controversial clinical setting. In this study, to clarify vivo role microenvironment, we s.c. inoculated Pan02 stably expressing S100A8 S100A9 proteins (Pan02-S100A8/A9) syngeneic C57BL/6 mice. Unexpectedly, after small nodules were once...
T-cell factor-4 (TCF4) is a transcription factor essential for maintaining the undifferentiated status and self-renewal of intestinal epithelial cells. It has therefore been considered that constitutive activation TCF4 by aberrant Wnt signaling major force driving colorectal carcinogenesis. We previously identified Traf2- Nck-interacting kinase (TNIK) as one proteins interact with in cancer cells, but its functional significance not elucidated. Here, we report TNIK an activating growth....
Rationale: Pancreatic cancer is associated with poor prognosis a 5-year survival rate of less than 6%.Approximately 90% pancreatic patients harbor somatic mutations in the KRAS gene.Multiple lines evidence suggest persistent activation STAT3 KRAS-driven oncogenesis contributing to desmoplasia and gemcitabine resistance.Sphingosine 1-phosphate receptor 1 (S1PR1) an integral component tumor progression maintains activated state STAT3.FTY720 approved drug for multiple sclerosis acts as...
It remains unclear whether the immunologic status of cells in peripheral blood can be used as a prognostic indicator response to treatment for patients with unresectable metastatic colorectal cancer (MCRC). We therefore investigated relationship between pretreatment 40 MCRC who planned receive first-line chemotherapy and their progression-free survival. Twenty-five immune cell subsets, including monocytic myeloid-derived suppressor (M-MDSC) effector memory T (TEM), were measured by...
One of the standard treatments resectable esophageal squamous cell carcinoma (ESCC) is neoadjuvant chemotherapy followed by surgery. Nivolumab showed efficacy for metastatic ESCC. However, safety and nivolumab with ESCC unknown. Therefore, we will conduct FRONTiER to evaluate adding chemotherapy. comprises four experimental cohorts: (A) including plus 5-FU+CDDP (cisplatin 5-fluorouracil [CF]); (B) one prior administration cohort A regimen; (C) docetaxel+ CF; (D) C an expanded cohort. The...
Two cases of pediatric lung cancer (in 23-month-old and 6-year-old boys) resulting from mother-to-infant transmission uterine cervical tumors were incidentally detected during routine next-generation sequencing paired samples tumor normal tissue. Spontaneous regression some lesions in the first child slow growth mass second suggested existence alloimmune responses against transmitted tumors. Immune checkpoint inhibitor therapy with nivolumab led to a strong all remaining child. (Funded by...
A total of 71 consecutive patients with unresectable hepatocellular carcinoma were analyzed retrospectively to determine the significant prognostic factors. All received systemic chemotherapy in a phase 2 study from 1980 1990, no other anticancer treatment. Median survival time and 1–yr 2–yr rates 5.6 mo, 23% 5%, respectively. By univariate analysis, performance status 0-1 tumor size less than 50% liver cross–sectional area shown be factors most significantly favoring better prognosis....
Clinicoradiological features were studied in 20 patients with 22 mass lesions of combined hepatocellular carcinoma and cholangiocarcinomas findings computed tomography 12 these 14 carcinoma-cholangiocarcinomas. Five also had single overt carcinomas. The incidence carcinoma-cholangiocarcinoma was 3.3% among the primary liver cancer treated our hospital. HBsAg present 25%, increased levels serum alpha-fetoprotein (> 200 ng/ml) carcinoembryonic antigen 5 found 25% 47%, respectively. Associated...
The aryl hydrocarbon receptor (AHR) pathway modulates the immune system in response to kynurenine, an endogenous tryptophan metabolite. IDO1 and TDO2 catalyze kynurenine production, which promotes cancer progression by compromising host immunosurveillance. However, it is unclear whether AHR activation regulates malignant traits of such as metastatic capability or stemness. Here, we carried out systematic analyses metabolites patient-derived colorectal spheroids identified high levels that...
Peritoneal dissemination is one of the most common complications malignancies digestive system, such as gastric or pancreatic cancers. Yet, no effective therapy has been established so far to alleviate this devastating and often fatal end-stage condition. Here we describe a novel approach intraperitoneal (i.p.) lipofection suicidal gene cancer cells in mouse peritoneal model. A human cell line, PSN-1, was inoculated into cavity nude mice. Eight days later, herpes simplex virus thymidine...
We have reported that interferon (IFN)-α can attack cancer cells by multiple antitumor mechanisms including the induction of direct cell death and enhancement an immune response in several pancreatic models. However, immunotolerant microenvironment tumors is often responsible for failure immunotherapy. Here we examined whether suppression regulatory T (Tregs) within enhance immunity induced intratumoral IFN-α gene transfer. First showed intraperitoneal administration agonistic...
129 Background: Nivolumab (Nivo) showed a survival benefit in salvage line of advanced gastric cancer (AGC) patients ATTRACTION-2 trial. Based on synergistic anti-tumor effects by simultaneous blockade PD-1 and VEGFR-2, this phase 1/2 study was conducted to investigate the safety efficacy Nivo plus ramucirumab (Ram) second chemotherapy for AGC. Methods: AGC with measurable lesions, PS 0-1, disease progression first containing platinum were eligible. Patients received (3mg/kg, Q2W) Ram...
Abstract Recurrence and treatment resistance are major causes of cancer-associated death. There has been a growing interest in better understanding epithelial–mesenchymal transition, stemness cancer cells, exhaustion dysfunction the immune system for which numerous genomic, proteomic, microenvironmental, immunologic mechanisms have demonstrated. However, practical treatments such patients not yet established. Here we identified IL33 as key driver polyploidy, followed by rapid proliferation...
286 Background: The standard neoadjuvant chemotherapy (NAC) in Japan for locally advanced esophageal squamous cell carcinoma (ESCC) consists of CDDP + 5-FU (CF). Recently, DTX plus CF (DCF) therapy has shown promising efficacy ESCC. In addition, immune checkpoint inhibitors (ICIs) have demonstrated a survival benefit ESCC and potential as an NAC several cancers, including lung, breast, skin, bladder. We previously reported that nivolumab (Nivo) was tolerable showed ESCC; however, the ICI...
Ki-ras point mutation characteristically occurs frequently in human pancreatic cancer. To clarify the effect of antisense RNA on various cancer cell lines, a plasmid expressing an gene fragment (AS-K-ras-LNSX) was transduced into seven lines (AsPC-1, MIA PaCa-2, PANC-1, PSN-1, BxPC-3, Hs 700T, and 766T) by liposome-mediated transfection. Western blot analysis showed that transfection AS-K-ras-LNSX led to significant reduction amounts p21 protein all except BxPC-3. The growth having mutations...
A phase 2 study of cisplatin was performed in 28 previously untreated patients with unresectable hepatocellular carcinoma. The drug given intravenously at a dose 80 mg/m2/day every 4 weeks. Of 26 evaluated, (15.4%) showed partial responses lasting for > 3 months, while no patient achieved complete response. 22 whose serum level α-fetoprotein (AFP) high ( 400 ng/ml) before treatment, 6 (27.3%) 50% reduction AFP levels after treatment. current indicates that is an anticancer agent worthy...