A5051061742- Prostate Cancer Treatment and Research
- Hormonal and reproductive studies
- Prostate Cancer Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Mast cells and histamine
- Urinary Bladder and Prostate Research
- Urological Disorders and Treatments
- Sexual Differentiation and Disorders
- Urologic and reproductive health conditions
- Bone health and treatments
- Curcumin's Biomedical Applications
- Urinary Tract Infections Management
- Renal cell carcinoma treatment
- Adrenal and Paraganglionic Tumors
- Sexual function and dysfunction studies
- Testicular diseases and treatments
- Sperm and Testicular Function
- Polyamine Metabolism and Applications
- Phytoestrogen effects and research
- MRI in cancer diagnosis
- Pediatric Urology and Nephrology Studies
- Pelvic floor disorders treatments
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
Juntendo University
2023-2025
Juntendo University Hospital
2024
Dokkyo Medical University
2018-2023
Social Insurance Saitama Chuo Hospital
2017-2023
Dokkyo Medical University Saitama Medical Center
2012-2022
Teikyo University
2009-2018
Teikyo University Hospital
2014-2015
Toho University
2012
Toho University Omori Medical Center
2012
National Hospital Organization
2012
BackgroundWe evaluated the efficacy and feasibility of high-intensity-focused ultrasound (HIFU) for localized prostate cancer.
The existence of a postnatal prostate stem cell is supported by several types evidence. Withdrawal androgen leads to involution the gland, but readdition can rapidly stimulate regeneration. Tissue fragments derived from mouse or rat prostatic epithelia midgestation embryos adult mice, when combined with tissue urogenital sinus mesenchyme and grafted under kidney capsule, regenerate structures. Indirect evidence supports that population contained within basal layer. Purified preparations...
Abstract BACKGROUND Sustained chronic inflammation in the prostate promotes carcinogenesis. Since an elevated level of prostate‐specific antigen (PSA) per se reflects presence prostate, intervention to improve PSA value might potentially have beneficial effects for prevention development cancer. Isoflavones and curcumin anti‐inflammatory anti‐oxidant properties. We examined biological soy isoflavones on LNCaP cells. After that, we conducted a clinical trial men who received biopsies, but...
Testosterone is crucial in regulating several body functions men, including metabolic, sexual, and cardiovascular functions, bone muscle mass, mental health. Therefore, optimizing testosterone levels men an important step to maintaining a healthy mind, especially as we age. However, traditional replacement therapy has been shown lead male infertility, caused by negative feedback the hypothalamic–pituitary–gonadal (HPG) axis. Recent advances research have led discovery of many new methods...
Abstract The relationship between the serum values of prostate specific antigen (PSA) and extent histological prostatitis was investigated in 42 patients undergoing transurethral resection for benign hyperplasia (BPH) without clinical evidence prostatitis. Histological divided into three groups: acute, chronic‐active, chronic‐inactive inflammation. expressed as number prostatic acinar ductal glands with inflammatory infiltrate per total (%). PSA significantly correlated acute chronic‐active...
Colony-stimulating factor-1 receptor (CSF-1R) is the major regulator of macrophage development and associated with epithelial cancers breast ovary. Immunohistochemistry analysis murine prostate demonstrated expression CSF-1R during protrusion prostatic buds from urogenital sinus, prepubertal androgen-driven proliferative expansion branching gland, a decline in older animals. Models cancer showed areas carcinoma- tumor-associated macrophages. Several human cell lines primary cultures cells...
Sarcopenia is a geriatric syndrome that characterized by the gradual muscle loss and frailty in elderly. Meanwhile, prevalence of prostate cancer on rise worldwide. Mainstay treatments for metastatic are androgen-deprivation therapy taxane-based chemotherapy. Owing to indolent nature cancer, these tend be long-lasting, giving problem tolerance treatments. Especially given fact long-term chemotherapy closely associated with loss, we aimed elucidate correlation between sarcopenia clinical...
Introduction The increasing prevalence of dementia in aging populations necessitates effective and accessible cognitive screening tools. This study aimed to evaluate the feasibility reliability a newly developed mobile app for detecting mild impairment (MCI). Methods app, by LifeQuest Co., Ltd. (Minato-ku, Tokyo), is an original tool inspired Japanese version Montreal Cognitive Assessment (MoCA-J). A prospective observational was conducted with 20 participants, including healthy individuals,...
Objectives: We attempt to assess whether prostate-specific antigen decline rate in the first month (PSADR1M = postoperative PSA month/initial PSA) acts as a predictor for biochemical recurrence (BCR) and evaluate other preoperative variables that may predict BCR following robot-assisted laparoscopic prostatectomy (RARP). Method: Based on D’Amico risk classification system, 777 patients who underwent RARP localized prostate cancer were classified into low/intermediate-risk group (n 435)...
Peritoneal dissemination is one of the most common complications malignancies digestive system, such as gastric or pancreatic cancers. Yet, no effective therapy has been established so far to alleviate this devastating and often fatal end-stage condition. Here we describe a novel approach intraperitoneal (i.p.) lipofection suicidal gene cancer cells in mouse peritoneal model. A human cell line, PSN-1, was inoculated into cavity nude mice. Eight days later, herpes simplex virus thymidine...
Intratumoral androgen biosynthesis has been recognized as an essential factor of castration‐resistant prostate cancer. The present study investigated the effects curcumin on inhibition intracrine synthesis in Human cancer cell lines, LNC aP and 22Rv1 cells were incubated with or without after which proliferation was measured at 0, 24, 48 72 hours, respectively. Prostate tissues from transgenic adenocarcinoma mouse ( TRAMP ) model obtained 1‐month oral administration 200 mg/kg/d curcumin....
Objectives To evaluate the efficacy of low‐intensity shock wave therapy and to identify predictive factors its in Japanese patients with erectile dysfunction. Methods The present study included 57 dysfunction who satisfied all following conditions: more than 6‐months history dysfunction, sexual health inventory for men score ≤12 without phosphodiesterase type‐5 inhibitor, erection hardness grade 1 or 2, mean penile circumferential change by erectometer assessing sleep related <25 mm...
Ki-ras point mutation characteristically occurs frequently in human pancreatic cancer. To clarify the effect of antisense RNA on various cancer cell lines, a plasmid expressing an gene fragment (AS-K-ras-LNSX) was transduced into seven lines (AsPC-1, MIA PaCa-2, PANC-1, PSN-1, BxPC-3, Hs 700T, and 766T) by liposome-mediated transfection. Western blot analysis showed that transfection AS-K-ras-LNSX led to significant reduction amounts p21 protein all except BxPC-3. The growth having mutations...
To evaluate the feasibility and accuracy of virtual partial nephrectomy analysis, including a color-coded three-dimensional surgical planning quantitative functional in predicting outcomes robot-assisted nephrectomy.Between 2012 2014, 20 patients underwent analysis before undergoing nephrectomy. Virtual was carried out with following steps: (i) evaluation arterial branch for selective clamping by showing vascular-supplied area; (ii) simulation optimal margin precise segmented model...
To determine the clinical predictive factors affecting recovery from postoperative urinary incontinence after robot-assisted radical prostatectomy (RARP).We consecutively analyzed 320 patients who underwent RARP between January 2012 and March 2015. The restoration of continence was defined as follows: use no pads/no leakage urine or a safety pad. Preoperative covariates were statistically assessed by multivariate logistic regression analysis to investigate their predict factor incontinence....
Testosterone plays a key role in the maintenance of physical and mental functions men. Age-related testosterone decline is closely associated with sarcopenia muscle deterioration, while linked etiology prevention diseases such as angina pectoris, arteriosclerosis, obesity, metabolic syndrome, dementia. Late-onset hypogonadism (LOH) defined disease characterized by age-related clinical symptoms. replacement therapy improves health-related QOL patients LOH.
Enzalutamide is a second-generation androgen receptor inhibitor that increases overall survival (OS) rates in patients with metastatic castration-resistant prostate cancer (mCRPC). This study evaluates the efficacy of circulating tumor cell (CTC) status as prognostic biomarker following enzalutamide administration. A retrospective subgroup analysis and survey were conducted on 43 mCRPC bone metastases treated Juntendo University-affiliated hospitals from 2015 to 2022. Patients 160 mg daily....
The mast cell protease inhibitor trypstatin was purified from rat peritoneal cells (Kido, H., Yokogoshi, Y., and Katunuma, N. (1988) J. Biol. Chem. 263, 18104-18107). We noticed that could possibly be identical with the second half of inter-alpha-trypsin light chain (ITI-LC), because only 5 amino acid residues are different sequence deduced recently reported ITI-LC mRNA. Southern blot analysis revealed a 170-base pair probe corresponding to hybridized digested genomic DNAs at single bands...
The prostate gland undergoes dramatic changes in growth status during normal physiologic development, following androgen administration to castrate animals, and tumor development. stem cell antigen (PSCA, named for its strong sequence homology the thymocyte marker 2) is a surface molecule associated with human murine cancer. To help define regulation of this molecule, we created transgenic mouse strain, which uses PSCA promoter region control expression enhanced green fluorescent protein...
A cDNA encoding mouse intestinal trefoil factor (mITF) was successfully cloned and sequenced from the small intestine of C57BL/6 by using combination reverse transcription-PCR rapid amplification ends methods. The gene was, similar to rat human ITFs, mainly expressed in large intestine. mITF expression up-regulated during recovery phase after depletion goblet cells acetic acid-induced colitis. On other hand, jejunum not altered, while cell hyperplasia induced Nippostrongylus brasiliensis...