A5089829213- Cancer Treatment and Pharmacology
- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Advanced Breast Cancer Therapies
- Breast Lesions and Carcinomas
- Cancer Diagnosis and Treatment
- Atmospheric chemistry and aerosols
- Atmospheric and Environmental Gas Dynamics
- Atmospheric Ozone and Climate
- Chronic Lymphocytic Leukemia Research
- Estrogen and related hormone effects
- Colorectal Cancer Treatments and Studies
- Health Systems, Economic Evaluations, Quality of Life
- Neutropenia and Cancer Infections
- Oral health in cancer treatment
- Cancer-related Molecular Pathways
- Head and Neck Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Multiple Myeloma Research and Treatments
- Cancer Risks and Factors
- Monoclonal and Polyclonal Antibodies Research
- Lung Cancer Treatments and Mutations
- Brain Metastases and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Statistical Methods in Clinical Trials
National Cancer Center Hospital East
2016-2025
University Hospital Kyoto Prefectural University of Medicine
2024-2025
Kyoto Prefectural University of Medicine
2019-2025
National Cancer Centre Japan
2023-2024
Aichi Cancer Center
2009-2022
Mie University Hospital
2016-2022
Nagoya City University
2019-2022
Kumamoto University
2022
St. Marianna University School of Medicine
2022
University of Tokyo Hospital
2019-2022
This paper documents a global Bayesian variational inversion of CO 2 surface fluxes during the period 1988–2008. Weekly are estimated on 3.75° × 2.5° (longitude‐latitude) grid throughout 21 years. The assimilated observations include 128 station records from three large data sets mixing ratio measurements. A Monte Carlo approach rigorously quantifies theoretical uncertainty inverted at various space and time scales, which is particularly important for proper interpretation fluxes. Fluxes...
BackgroundStandard first-line treatment of metastatic triple-negative breast cancer (mTNBC) is chemotherapy. However, outcomes are poor, and new options needed. In cohort B the phase II KEYNOTE-086 study, we evaluated pembrolizumab as therapy for patients with PD-L1-positive mTNBC.Patients methodsEligible had centrally confirmed mTNBC, no prior systemic anticancer disease, measurable disease at baseline per RECIST v1.1 by central review, radiographic evidence nervous system metastases, a...
The efficacy of lapatinib versus trastuzumab combined with taxanes in the first-line setting human epidermal growth factor receptor 2 (HER2) -positive metastatic breast cancer (BC) is unknown.The MA.31 trial compared a combination anti-HER2 therapy (lapatinib or trastuzumab) and taxane for 24 weeks, followed by same monotherapy until progression. Stratification was prior (neo)adjuvant therapy, taxane, planned liver metastases. primary end point intention-to-treat (ITT) progression-free...
Although gene expression profiling is a promising diagnostic technique to determine the tissue of origin for patients with cancer unknown primary site (CUP), no clinical trial has evaluated yet site-specific therapy directed by this approach compared empirical chemotherapy. We therefore performed randomized study assess whether such improves outcome chemotherapy in previously untreated CUP.Comprehensive was microarray analysis, and an established algorithm applied predict tumor origin....
Abstract. This study uses a neural network technique to produce maps of the partial pressure oceanic carbon dioxide (pCO2sea) in North Pacific on 0.25° latitude × longitude grid from 2002 2008. The pCO2sea distribution was computed using self-organizing map (SOM) originally utilized Atlantic. Four proxy parameters – sea surface temperature (SST), mixed layer depth, chlorophyll concentration, and salinity (SSS) are used during training phase enable resolve nonlinear relationships between...
NK105 is a novel nanoparticle drug delivery formulation that encapsulates paclitaxel (PTX) in polymeric micelles. We conducted an open-label phase III non-inferiority trial to compare the efficacy and safety of PTX metastatic or recurrent breast cancer. Patients were randomly assigned 1:1 ratio receive either (65 mg/m2) (80 on days 1, 8 15 28-day cycle. The primary endpoint was progression-free survival (PFS), with margin 1.215. A total 436 patients randomised 211 each group included...
Abstract. In situ observation of the atmospheric CO2, CH4, and CO mixing ratios at Hateruma Island (HAT, 24.05° N, 123.80° E) often show synoptic-scale variations with correlative elevations during winter, associated air transport from East Asian countries. We examine winter (November– March) trends in ΔCH4 / ΔCO2, ΔCO observed over period 1999 to 2010. To investigate relationship between emissions short-term ratios, we use FLEXPART Lagrangian particle dispersion model (LPDM). The ΔCO2 both...
Nivolumab is a human monoclonal antibody against the immune checkpoint receptor programmed death-1, inhibiting binding to death-ligand 1 or 2 (PD-L1 PD-L2). This phase study evaluated efficacy and safety of nivolumab in patients with advanced/recurrent uterine cervical cancer, corpus soft tissue sarcoma (STS). Patients received 240 mg at 2-week intervals. Primary endpoint was objective response rate; secondary endpoints included overall survival, progression-free safety. PD-L1 expression...
Adjuvant trastuzumab monotherapy has not been compared with + chemotherapy. We investigated the relative value of for older patients breast cancer.This study was an open-label, randomized controlled a treatment selection design in which noninferiority criterion predefined. Patients aged 70-80 years surgically treated human epidermal growth factor receptor 2-positive invasive cancer received or The primary end point disease-free survival (DFS) assessment prespecified hazard ratio (HR),...
High frequency monitoring of hydrofluorocarbons (HFCs) and some other halocarbons in the atmosphere has been performed at Hateruma Island (lat. 24.1°N, long. 123.8°E), a background site east Asia. The observed concentrations showed occasional short‐term enhancement events over hours to days as well clear seasonal variation, being lower summer than seasons. We found that HFC‐23 enhancements were closely related air transport from China. Using tagged simulation three‐dimensional model...
Objective To evaluate the effects of genetic polymorphisms drug metabolizing enzymes on pharmacokinetics cyclophosphamide and its active metabolite, 4-hydroxycyclophosphamide, pharmacodynamics. Experimental Design One hundred three Japanese patients with malignant lymphoma or breast cancer treated (500–750 mg/m2) participated in this study. The plasma concentrations 4-hydroxycyclophosphamide were determined by high-performance liquid chromatography, pharmacokinetic parameters calculated....
Sorafenib is a novel oral multikinase inhibitor that targets Raf serine/threonine and receptor tyrosine kinases, inhibits tumor cell proliferation angiogenesis. We have conducted phase I study of sorafenib to determine the safety, tolerability, pharmacokinetics, potential efficacy this agent in 31 Japanese patients with advanced refractory solid tumors. (100–600 mg) was given as single dose followed by 7‐day wash‐out period, then administrated twice daily (bid). The most frequent...
BackgroundBreast Cancer Trials of Oral Everolimus 2 (BOLERO-2), a phase III study in postmenopausal women with estrogen receptor–positive breast cancer progressing despite nonsteroidal aromatase inhibitor therapy, showed statistically significant benefits adding everolimus to exemestane. Moreover, preclinical studies, mammalian target rapamycin inhibition was associated decreased osteoclast survival and activity. Exploratory analyses BOLERO-2 evaluated the effect on bone marker levels...
Abstract. We examined potential interferences from water vapor and atmospheric background gases (N2, O2, Ar), biases by isotopologues of target species, on accurate measurement CO2 CH4 means wavelength-scanned cavity ring-down spectroscopy (WS-CRDS). Changes the gas mole fractions in sample air substantially impacted measurements: variation due to relative increase each increased as Ar < O2 N2, suggesting similar relation for pressure-broadening effects (PBEs) among gas. The coefficients...
Abstract. We present a global dataset of CO2 emissions and O2 uptake associated with the combustion different fossil fuel types. To derive spatial temporal patterns oxygen uptake, we combined high-resolution from EDGAR (Emission Database for Global Atmospheric Research) inventory country level information on oxidative ratios, based consumption data UN energy statistics database. The results are hourly maps resolution 1°×1° years 1996–2008. potential influence trends in resulting O2/CO2...
This phase I study in Japanese patients evaluated the safety, pharmacokinetics, and preliminary efficacy of palbociclib, a highly selective reversible oral cyclin‐dependent kinase 4/6 inhibitor, as monotherapy for solid tumors (part 1) combined with letrozole first‐line treatment postmenopausal estrogen receptor‐positive, human epidermal growth factor receptor 2‐negative advanced breast cancer 2). Part 1 palbociclib 100 125 mg once daily (3 weeks on/1 week off; n = 6 each group) to determine...
1088 Background: Standard first-line treatment for mTNBC is chemotherapy. However, outcomes are poor, and new options needed. Cohort B of KEYNOTE-086 (NCT02447003) assessed the safety antitumor activity pembrolizumab as therapy patients (pts) with PD-L1–positive mTNBC. Methods: Men women centrally confirmed mTNBC, no prior systemic anticancer metastatic disease, ECOG PS 0-1, a tumor PD-L1 combined positive score (CPS) ≥1% received 200 mg Q3W 24 mo or until disease progression, intolerable...