A5022126823- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Cancer Treatment and Pharmacology
- Cancer Diagnosis and Treatment
- Birth, Development, and Health
- Electrolyte and hormonal disorders
- Neonatal Respiratory Health Research
- Monoclonal and Polyclonal Antibodies Research
- Fatty Acid Research and Health
- Nitric Oxide and Endothelin Effects
- Metastasis and carcinoma case studies
- Reconstructive Surgery and Microvascular Techniques
- Hair Growth and Disorders
- Metabolism and Genetic Disorders
- Colorectal and Anal Carcinomas
- AI in cancer detection
- Anesthesia and Neurotoxicity Research
- Colorectal Cancer Surgical Treatments
- Peptidase Inhibition and Analysis
- Breast Implant and Reconstruction
- Protein Tyrosine Phosphatases
- Balance, Gait, and Falls Prevention
- Advanced Breast Cancer Therapies
- Neutropenia and Cancer Infections
- Pregnancy and Medication Impact
Ogikubo Hospital
2021-2022
Tokyo Medical and Dental University
2022
Kameda Medical Center
2016-2021
Oita University
2018-2020
National Cancer Center Hospital East
2016-2019
Okayama University Hospital
2016-2019
Aichi Cancer Center
2016-2019
University of Tokyo Hospital
2019
The Cancer Institute Hospital
2019
Okinawa Prefectural Yaeyama Hospital
2017
Adjuvant trastuzumab monotherapy has not been compared with + chemotherapy. We investigated the relative value of for older patients breast cancer.This study was an open-label, randomized controlled a treatment selection design in which noninferiority criterion predefined. Patients aged 70-80 years surgically treated human epidermal growth factor receptor 2-positive invasive cancer received or The primary end point disease-free survival (DFS) assessment prespecified hazard ratio (HR),...
We report findings on quality of life (QoL) in the RESPECT trial, which compared adjuvant trastuzumab monotherapy with plus chemotherapy older patients human epidermal growth factor receptor 2 (HER2)-positive breast cancer (BC).Patients age 70-80 years 2-positive surgically treated were randomly assigned to receive (T) or (T + C). QoL was assessed using Functional Assessment Cancer Therapy-General (FACT-G), Philadelphia Geriatric Center Morale Scale, Hospital Anxiety and Depression Patient...
510 Background: The relative value of trastuzumab (H) monotherapy as an adjuvant treatment compared to the standard combination with chemotherapy (CT) is not clear for elderly breast cancer (BC) patients (pts). Methods: We randomly assigned pts over 70 years (yrs) old HER2-positive invasive BC who received curative surgery into either H (H group) or plus CT (H+CT selected from pre-specified regimens (PTX/DTX/TC/AC/EC/FEC/CMF/TCb [CBDCA]). primary endpoint was disease-free survival (DFS), and...
Chemotherapy-induced alopecia is one of the most difficult adverse events cancer treatment for patients. However, it still unknown why anticancer drugs cause hair loss. We aimed to clarify mechanism chemotherapy-induced in mice using an vivo imaging technique with a two-photon microscope, which enables observation deep reaction living body real time. In this study, ICR were injected intraperitoneally cyclophosphamide (120 µg/g). Changes bulb morphology, subcutaneous vessel permeability, and...
Background and objectives: In the treatment of special type breast cancer (STBC), choice chemotherapeutic agents is often based on characteristic features histological type. On other hand, surgical strategy usually determined by tumor size presence lymph node metastasis, indication for immediate reconstruction rarely discussed The prognoses STBC invasive ductal carcinoma (IDC) patients who underwent subcutaneous mastectomy (SCM) with at our institution were compared. Materials Methods: A...
Abstract OBJECTIVE: The RESPECT trial compared 1-year trastuzumab monotherapy with plus standard chemotherapy as a postoperative adjuvant therapy in HER2-positive elderly breast cancer patients. Primary objective of this study was to verify the noninferiority terms disease free survival, and planned analysis showed that difference restricted mean survival time between two groups at 3 years 0.45 months (reported by Sawaki ASCO2018). This report assesses patients-reported outcomes...
Abstract Background: Health-related quality of life (HRQoL) is one the important outcomes in cancer control trials and has increasingly become primary foci. Obtaining informed consent from participants essential for participation randomized controlled (RCTs), but these RCTs may directly influence HRQoL, because treatment options are determined according to allocation schedule. To date, only a few studies have compared HRQoL between clinical trial decliners. Patients Method: The National...
目的:乳癌診療において乳房超音波検査（乳房US）は必須だが，問題点として施行者に依存し，客観性に乏しいことがあげられる．これを克服するために開発された技術の一つにAutomated Breast Volume Scanner（ABVS）がある．今回われわれは，マンモグラフィおよびhand-held USと比較したABVS検出能について検討した．方法:マンモグラフィ，hand-held USおよびABVSを施行した324例のうち，病理組織検査で乳癌と確定診断された連続30例を対象とした．全症例がマンモグラフィ・乳房US（ABVS・hand-held US）を施行した．ABVSによる病変の検出とカテゴリーに関してマンモグラフィとhand-held USのそれらと比較して評価した．結果:浸潤癌は21例（19例が浸潤性乳管癌，1例が浸潤性小葉癌，1例が粘液癌），非浸潤性乳管癌は9例であった．ABVS・hand-held USにより乳癌全例が描出され，かつカテゴリー4以上であった．一方，4例はマンモグラフィではカテゴリー1または2であった．結論:今回の結果からABVSはhand-held...
e19504 Background: Hypersensitivity reaction (HR) to carboplatin (CBDCA) restrains adequate therapy in cancer patients. Reliable vitro test detect and predict HR is not currently available. We hypothesized that CD203+ basophils are useful marker carboplatin-related hypersensitivity. Methods: This prospective case-control study comprised 29 patients with gynecologic cancers consulted our institution from October 2009 through September 2010. Among these patients, 11 had a history of...
16575 Background: There is no standard chemotherapy regimen for gynecological cancer patients with venous thrombosis. The goal of this study was to evaluate the safety and toxicity weekly low-dose paclitaxel plus carboplatin therapy in ovarian or endometrial who had deep vein Methods: Ovarian thrombosis were scheduled receive neoadjuvant adjuvant eligible inclusion study. One cycle treatment consisted (at an area under curve 2) 80 mg/m2) on days 1, 8, 15 a 21-day cycle. After premedication...
Abstract Background:There are several small case series about the omental flap for breast reconstructions. However, long-term oncological safety and clinical benefits remain uncertain, especially is used as a part of oncoplastic surgery. We retrospectively studied 200 patients who underwent surgery using laparoscopically harvested flap. Methods:A retrospective chart review at our institution from April 2002 to March 2016 was performed. All flaps were harvested, mainly partial reconstruction...
hernia 143 Dichorionic triplet pregnancy 428 Diethylstilbestrol 128 Diffuse chorioangiomatosis 183 Diode 33 Doppler sonography 452 -ultrasound 289 -velocimetry 149 Dried blood spots 41 Dystobrevin 29 Early diagnosis 55 Echocardiography, fetal 335 Elevated maternal serum alpha-fetoprotein 18 Emergency 139 Escherichia coli 217
Diabetes increases fall and fracture risk, but the association of impaired fasting glucose (IFG) with treated injuries is unknown. We assessed diabetes (diagnosed/treated and/or FG≥126 mg/dl) IFG (FG≥100 in Cox Proportional Hazard models for injury from linked Medicare Fee-For-Service claims over 8.6 ± 3.3 years Health ABC (n=2363, age 73.5 2.8 years, 52% women, 38% black, 18% IFG, 17% diabetes). Fall (n=680; 29%) were 76% fractures 24% non-fracture injuries. After adjusting...
Background: Recently, laparoscopic (Lap) intersphincteric resection (ISR) for low-lying rectal cancer is gradually permeating worldwide. However, the usefulness of Lap-ISR after neoadjuvant chemoradiotherapy (NCRT) has not been clarified. This retrospective study aimed to evaluate feasibility NCRT locally advanced cancer. Methods: Fourteen patients with primary were enrolled in this and underwent curative between January 2008 December 2011. Seven (NCRT group) seven without (non-NCRT...
SafetyAll adverse events ( n = 11, 11%) were grade 1 or 2,and these included scalp pain 3 ), pruritus and rash 5) .Symptoms associated with hair loss found in 53 patients (52%), including 25 itching 35 patients.
Background: Recently, laparoscopic (Lap) intersphincteric resection (ISR) for low-lying rectal cancer is gradually permeating worldwide. However, the usefulness of Lap-ISR after neoadjuvant chemoradiotherapy (NCRT) has not been clarified. This retrospective study aimed to evaluate feasibility NCRT locally advanced cancer. Methods: Fourteen patients with primary were enrolled in this and underwent curative between January 2008 December 2011. Seven (NCRT group) seven without (non-NCRT group)....