A5052596898- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Gastrointestinal disorders and treatments
- Inflammatory Bowel Disease
- Gastrointestinal Bleeding Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Microbial Metabolic Engineering and Bioproduction
- Microscopic Colitis
- Spectroscopy and Quantum Chemical Studies
- Esophageal and GI Pathology
- Colorectal Cancer Surgical Treatments
- Protein Structure and Dynamics
- Esophageal Cancer Research and Treatment
- Colorectal Cancer Treatments and Studies
- Amino Acid Enzymes and Metabolism
- Heat shock proteins research
- Diverticular Disease and Complications
- Mycobacterium research and diagnosis
- Inflammatory mediators and NSAID effects
- Gastroesophageal reflux and treatments
- Colorectal and Anal Carcinomas
- Respiratory and Cough-Related Research
Juntendo University Urayasu Hospital
2022-2024
Wakamoto Pharmaceutical (Japan)
2024
University of Tsukuba
1994-2023
Saiseikai Ibaraki Hospital
2023
Liechtenstein Institute
2023
Juntendo University
2013-2022
Kyushu Institute of Technology
2022
Juntendo University Hospital
2010-2021
University of Tsukuba Hospital
2017
Tohoku University
2010
Background and Aim The Japan narrow‐band imaging (NBI) Expert Team (JNET) was organized to unify four previous magnifying NBI classifications (the Sano, Hiroshima, Showa, Jikei classifications). JNET working group created criteria (referred as the scale) for evaluation of vessel pattern (VP) surface (SP). We conducted a multicenter validation study scale develop classification colorectal lesions. Methods Twenty‐five expert colonoscopists read 100 still images with without magnification on...
Endoscopic mucosal resection (EMR) is the gold standard for treatment of noninvasive large colorectal lesions, despite challenges associated with nonlifting lesions and a high rate local recurrence. submucosal dissection (ESD) offers possibility overcoming these EMR limitations. However, higher risk complications longer procedure time prevented its dissemination. As ESD now provides more stable results because standardized techniques compared those used earlier, this study aimed to quantify...
Glutamate dehydrogenase (L-glutamate:NADP+ oxidoreductase [deaminating], EC 1.4.1.4) has been purified from Escherichia coli B/r. The purity of the enzyme preparation established by polyacrylamide gel electrophoresis, ultracentrifugation, and filtration. A molecular weight 300,000 +/- 20,000 calculated for sedimentation equilibrium measurements. Polyacrylamide electrophoresis in sodium dodecyl sulfate measurements guanidine hydrochloride have revealed that glutamate consists polypeptide...
Background: The burden from depression is affected by the public’s beliefs, stigma, and resulting behavior. Lack of knowledge, misunderstanding, stigma about depressed people their surroundings are barriers to improving mental health. This study aimed examine public beliefs regarding depression, especially how recognize treatment, stigma. Methods: A self-administered questionnaire was distributed participants receiving an annual health checkup. We asked whether they agreed with four short...
Abstract Background and Aim: Colonoscopy plays an integral role in the diagnosis, management surveillance of ulcerative colitis (UC). In present study we assessed relationship between endoscopic histological findings, clinical symptoms, laboratory data. Methods: We performed total colonoscopy examinations 54 consecutive patients with UC. Seven segments (appendiceal region, cecum, ascending colon, transverse descending sigmoid rectum) were scored for activity. The also evaluated using a...
This study evaluated inter- and intraobserver agreement in the assessment of ulcerative colitis (UC) activity using 4 established indices a newly designed Modified 6-point Activity Index. In all, 279 endoscopic pictures inflammatory lesions from 93 UC patients were displayed twice to expert trainee endoscopists, at an interval 1 month. Each picture was assessed for changes (Matts, Schroeder [a.k.a. Mayo Score], Baron, Blackstone) our new Weighted kappa statistics used estimate intra-...
Endoscopic submucosal dissection (ESD) is a recently developed technique, but it not widely used to treat the colorectum because of its degree technical difficulty. It possible that traction lesion may facilitate correct visualization and make easier dissect. Several techniques involving have been reported [1] [2] [3] [4]. However, these methods employed date due difficulty in both fit ease use. We therefore designed new device, "S-O clip (Sakamoto-Osada clip)", for ESD.
Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are indicated for the treatment of large early-stage superficial colorectal cancers. Bleeding perforation common complications EMR ESD, but closure defect reduces risk complications. Hemoclips have been used defects, they can only be when diameter is less than width open clip. Because it quite difficult to do, not close defects despite increased bleeding perforation. A few techniques involving devices reported [1]...
Abstract Xanthosine 5'-phosphate aminase (xanthosine 5'-phosphate:ammonia ligase (AMP), EC 6.3.4.1) was purified from Escherichia coli B-96. The purity of the enzyme preparation established by its behavior in disc gel electrophoresis, ultracentrifugation, and filtration. extinction coefficient (E1%280) determined to be 11.2 cm-1 with use analytical ultracentrifuge as a differential refractometer. diffusion (D020,w) 5.09 x 10-7 cm2 s-1 obtained measurement free ultracentrifuge. Differential...
Background/Aims: To evaluate the usefulness of linked color imaging (LCI) and blue LASER (BLI) in Barrett’s esophagus (BE) compared with white light (WLI). Methods: Five expert trainee endoscopists WLI, LCI, BLI images obtained from 63 patients short-segment BE. Physicians assessed visibility as follows: 5 (improved), 4 (somewhat improved), 3 (equivalent), 2 decreased), one (decreased). Scores were evaluated to assess visibility. The inter- intra-rater reliability (intra-class correlation...
Colorectal sessile serrated adenoma/polyps (SSA/Ps) are considered early precursor lesions in the neoplasia pathway. Recent studies have shown associations of SSA/Ps with lost MLH1 expression, a CpG island methylator phenotype, and BRAF mutations. However, molecular biological features neoplastic progression not yet been fully elucidated, owing to rarity cases SSA/P advanced histology such as cytologic dysplasia or invasive carcinoma. In this study, we aimed elucidate dysplasia/carcinoma,...
The main factor that make endoscopic submucosal dissection (ESD) a difficult procedure is the risk associated with cutting along line of layer blind: cut edge lesion curls inwards and obscures endoscopist's view. Several methods have been devised to facilitate visibility [1] [2] [3], however, no devices yet developed meet demands convenience, cost, sterility, safety. Furthermore, most lift up only one part lesion, which means resection can be carried out from side; their use also limited...
Self-medication using over-the-counter (OTC) medicines is one of the effective self-care measures in dealing with daily health problems. Health literacy (HL) critical to ensuring appropriate use OTC medicines. The purpose this study was evaluate association between HL and comprehension medication package inserts among adults who We conducted a cross-sectional self-administered questionnaire interviews at 14 drugstores Kanto region Japan from January February 2020. participants were aged 20...